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Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

Zaldivar-Diez, Josefa, Li, Lingling, Garcia, Ana M., Zhao, Wen-Ning, Medina-Menendez, Cristina, Haggarty, Stephen. J., Gil, Carmen, Morales, Aixa V., Martinez, Ana·2020·Journal of Medicinal Chemistry
DOI 10.1021/acs.jmedchem.9b01752
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Abstract

Leucine rich repeat kinase 2 (LRRK2) is an enigmatic enzyme and a relevant target for Parkinson's disease (PD). However, despite the significant amount of research done in the past decade, the precise function of LRRK2 remains largely unknown. Moreover, the therapeutic potential of its inhibitors is in its infancy with the first clinical trial having just started. In the present work, the molecular mechanism of LRRK2 in the control of neurogenesis or gliogenesis was investigated. We designed and synthesized novel benzothiazole-based LRRK2 inhibitors and showed that they can modulate the Wnt/β-catenin signaling pathway. Furthermore, compounds 5 and 14 were able to promote neural progenitors proliferation and drive their differentiation toward neuronal and oligodendrocytic cell fates. These results suggest potential new avenues for the application of LRRK2 inhibitors in demyelinating diseases in which oligodendrocyte cell-death is one of the pathological features.

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Research works printed but not linked: 56

  1. 10.4155/fmc-2016-0214 · DOI
  2. 10.1080/14728222.2017.1323881 · DOI
  3. 10.1016/j.expneurol.2017.07.019 · DOI
  4. 10.1007/s00239-008-9122-4 · DOI
  5. 10.1007/s11033-014-3111-z · DOI
  6. 10.1016/j.tins.2006.03.006 · DOI
  7. 10.1111/j.1742-4658.2009.07341.x · DOI
  8. 10.7554/eLife.12813 · DOI · Paper page
  9. 10.1093/hmg/ddq289 · DOI
  10. 10.1038/emboj.2008.163 · DOI
  11. 10.1093/hmg/dds244 · DOI
  12. 10.5607/en.2010.19.2.97 · DOI
  13. 10.1111/j.1471-4159.2009.06235.x · DOI
  14. 10.3389/fnmol.2014.00049 · DOI · Paper page
  15. 10.1093/hmg/ddu138 · DOI · Paper page
  16. 10.1042/BST20160262 · DOI
  17. 10.1007/s00018-014-1774-1 · DOI
  18. 10.1016/j.ejmech.2017.06.060 · DOI
  19. 10.1177/1073858416667270 · DOI
  20. 10.1038/nature04108 · DOI
  21. 10.1002/stem.589 · DOI
  22. 10.1016/j.neuroscience.2015.02.049 · DOI
  23. 10.1016/j.lfs.2016.06.024 · DOI
  24. 10.1002/stem.1708 · DOI
  25. 10.1016/j.neubiorev.2014.09.005 · DOI
  26. 10.3389/fncel.2013.00082 · DOI
  27. 10.1093/hmg/ddp337 · DOI
  28. 10.1093/hmg/dds342 · DOI
  29. 10.1186/s13024-017-0153-4 · DOI
  30. 10.1042/BST20180464 · DOI
  31. 10.1021/jm300452p · DOI
  32. 10.1016/j.parkreldis.2009.11.004 · DOI
  33. 10.1038/nchembio.538 · DOI
  34. 10.1016/S0223-5234(03)00012-6 · DOI · Paper page
  35. 10.1021/jm990968+ · DOI
  36. 10.1016/j.arr.2017.06.001 · DOI
  37. 10.1177/1087057112456876 · DOI
  38. 10.1186/1756-0500-7-273 · DOI
  39. 10.1016/j.stem.2012.05.012 · DOI
  40. 10.1016/j.cell.2014.01.044 · DOI · Paper page
  41. 10.1002/ana.21019 · DOI
  42. 10.1016/j.neuroscience.2007.05.027 · DOI
  43. 10.1002/ar.22746 · DOI
  44. 10.1021/jm5014055 · DOI
  45. 10.3389/fncel.2016.00055 · DOI
  46. 10.1093/hmg/ddl471 · DOI · Paper page
  47. 10.1042/BCJ20160557 · DOI · Paper page
  48. 10.1042/BCJ20160671C · DOI
  49. 10.1021/jm500065f · DOI
  50. 10.1080/14756366.2018.1445736 · DOI
  51. 10.1038/nbt1358 · DOI · Paper page
  52. Schrödinger Release 2015-4: Maestro ; Schrödinger, LLC: New York, NY, 2015. · DOI
  53. 10.1021/ja9621760 · DOI
  54. Schrödinger Release 2015-4: LigPrep ; Schrödinger, LLC: New York, NY, 2015. · DOI
  55. Schrödinger Release 2015-4: Glide ; Schrödinger, LLC: New York, NY, 2015. · DOI
  56. 10.1002/stem.2397 · DOI

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Metadata

Authors
Zaldivar-Diez, J., Li, L., Garcia, A. M., Zhao, W.-N., Medina-Menendez, C., Haggarty, S. J., Gil, C., Morales, A. V., & Martinez, A.
Venue
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Published
2019-12-11
Volume
63
Issue
5
Pages
2638-2655
ISSN
  • 0022-2623
  • 1520-4804
DOI
10.1021/acs.jmedchem.9b01752
Cited by
20
References
3
Language
en
Licence
Funders
  • Ministerio de Econom?a y Competitividad (SAF2016-76693-R, SAF2017-85717-R)
  • Ministerio de Educaci?n, Cultura y Deporte (FPU13-003262)
  • Fundacion Alicia Koplowitz
  • Tau Consortium
  • Centro de Investigaci?n Biom?dica en Red sobre Enfermedades Neurodegenerativas (CB18/05/00040)

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