Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neurons
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In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS. Here, we provide evidence of a primary role for canonical Wnt/β-catenin signaling in regulating NSC fate along neuronal and oligodendroglial lineages in the postnatal SVZ. Our findings demonstrate that glutamatergic neuronal precursors (NPs) and oligodendrocyte precursors (OPs) are derived strictly from the dorsal SVZ (dSVZ) microdomain under the control of Wnt/β-catenin, whereas GABAergic NPs are derived mainly from the lateral SVZ (lSVZ) microdomain independent of Wnt/β-catenin. Transcript analysis of microdissected SVZ microdomains revealed that canonical Wnt/β-catenin signaling was more pronounced in the dSVZ microdomain. This was confirmed using the β-catenin-activated Wnt-reporter mouse and by pharmacological stimulation of Wnt/β-catenin by infusion of the specific glycogen synthase kinase 3β inhibitor, AR-A014418, which profoundly increased the generation of cycling cells. In vivo genetic/pharmacological stimulation or inhibition of Wnt/β-catenin, respectively, increased and decreased the differentiation of dSVZ-NSCs into glutamatergic NPs, and had a converse effect on GABAergic NPs. Activation of Wnt/β-catenin dramatically stimulated the generation of OPs, but its inhibition had no effect, indicating other factors act in concert with Wnt/β-catenin to fine tune oligodendrogliogenesis in the postnatal dSVZ. These results demonstrate a role for Wnt/β-catenin signaling within the dorsal microdomain of the postnatal SVZ, in regulating the genesis of glutamatergic neurons and OLs.
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Wnt and Smoothened signaling, as well as primary cilium pathways, were up-regulated in male lateral and female septal samples.
“Wnt and Smoothened signaling, as well as primary cilium pathways (Ahn and Joyner, 2005; Azim et al., 2014; Ihrie et al., 2011), were up-regulated in male lateral and female septal samples.”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Azim et al., 2014
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Self-citationStem Cell Therapy in Children with Traumatic Brain Injury
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Postnatal Neural Stem Cells: Probing Their Competence for Cortical Repair
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Self-citationGalectin-3 diminishes Wnt signaling in the postnatal subventricular zone
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Neuronal Subtype Generation During Postnatal Olfactory Bulb Neurogenesis
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Oligodendroglial physiology and function
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Could the inhibitor of DNA binding 2 and 4 play a role in white matter injury?
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Heterogeneity of Neural Stem Cells in the Ventricular–Subventricular Zone
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Self-citationmiRNAs in Mammalian Adult Olfactory Neurogenesis
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Self-citationNeurogenesis in the damaged mammalian brain
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Neural stem cells-from quiescence to differentiation and potential clinical uses
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Exploring Transcriptional Heterogeneity in the Postnatal SVZ
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- Authors
- Azim, K., Fischer, B., Hurtado‐Chong, A., Draganova, K., Cantù, C., Zemke, M., Sommer, L., Butt, A., & Raineteau, O.
- Affiliations
- University of Zurich (CH)
- Brain Research Institute, University of Zürich/ETHZZürich Switzerland
- University of Portsmouth (GB)
- Inserm (FR)
- Corresponding author
- Butt, Arthur
- Raineteau, Olivier
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-17
- Volume
- 32
- Issue
- 5
- Pages
- 1301-1312
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1936856856
- Cited by
- 88
- References
- 35
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 15 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 11 · 2014: 4
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Stem Cells (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Agence Nationale de la Recherche (ANR-11-IDEX-0007)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt/β-catenin signaling, subventricular zone, oligodendrocyte precursor cells, glutamatergic neurons, GABAergic neurons, neuronal lineage specification, glycogen synthase kinase-3β inhibition, AR-A014418
- MeSH terms
- Animals, Mice, Transgenic, Neurons, Oligodendroglia, Thiazoles, Urea, Blotting, Western, Signal Transduction, Microscopy, Confocal, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Lateral Ventricles, Glycogen Synthase Kinase 3, Cell Proliferation, Green Fluorescent Proteins, beta Catenin, Neural Stem Cells, Wnt3 Protein
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