Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
Open accessAbstract
The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that give rise to neuronal and oligodendroglial progeny. However it is not known whether the same aNSC can give rise to neuronal and oligodendroglial progeny or whether these distinct progenies constitute entirely separate lineages. Continuous live imaging and single-cell tracking of aNSCs and their progeny isolated from the mouse SEZ revealed that aNSCs exclusively generate oligodendroglia or neurons, but never both within a single lineage. Moreover, activation of canonical Wnt signalling selectively stimulated proliferation within the oligodendrogliogenic lineage, resulting in a massive increase in oligodendrogliogenesis without changing lineage choice or proliferation within neurogenic clones. In vivo activation or inhibition of canonical Wnt signalling respectively increased or decreased the number of Olig2 and PDGFR- α positive cells, suggesting that this pathway contributes to the fine tuning of oligodendrogliogenesis in the adult SEZ.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oligodendrocytes and astrocytes are also generated in the adult V-SVZ.
“Although oligodendrocytes and astrocytes are also generated in the adult V-SVZ (Menn et al., 2006; Nait-Oumesmar et al., 1999; Ortega et al., 2013; Sohn et al., 2015; Xing et al., 2014), their lineage trajectories are less clear.”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Ortega et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Long-Distance Neuronal Migration in the Adult Mammalian Brain
Lois, C., & Álvarez-Buylla, A. (1994) · Science · doi:10.1126/science.8178174 · Cited by 2,331 · see citing works
Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,510 · see citing works
Chain Migration of Neuronal Precursors
Lois, C., García-Verdugo, J.-M., & Alvarez-Buylla, A. (1996) · Science · doi:10.1126/science.271.5251.978 · Cited by 1,331 · see citing works
EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells
Doetsch, F. K., Petreanu, L., Caillé, I., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01133-9 · Cited by 1,048 · see citing works
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015 · see citing works
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972 · see citing works
Mosaic Organization of Neural Stem Cells in the Adult Brain
Merkle, F. T., Mirzadeh, Z., & Álvarez-Buylla, A. (2007) · Science · doi:10.1126/science.1144914 · Cited by 821 · see citing works
The glial identity of neural stem cells
Doetsch, F. (2003) · Nature Neuroscience · doi:10.1038/nn1144 · Cited by 724 · see citing works
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works
Neuronal fate determinants of adult olfactory bulb neurogenesis
Hack, M., Saghatelyan, A., de Chevigny, A., Pfeifer, A., Ashery-Padan, R., Lledo, P., & Götz, M. (2005) · Nature Neuroscience · doi:10.1038/nn1479 · Cited by 648 · see citing works
Continuous single-cell imaging of blood generation from haemogenic endothelium
Eilken, H. M., Nishikawa, S., & Schroeder, T. (2009) · Nature · doi:10.1038/nature07760 · Cited by 572 · see citing works
Self-citationDimou, L., Simon, C., Kirchhoff, F., Takebayashi, H., & Götz, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2831-08.2008 · Cited by 551 · see citing works
Self-citationDirecting Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons
Heinrich, C., Blum, R., Gascón, S., Masserdotti, G., Tripathi, P., Sánchez, R., Tiedt, S., Schroeder, T., Götz, M., & Berninger, B. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000373 · Cited by 490 · see citing works
Self-citationPicard-Riéra, N., Decker, L., Delarasse, C., Goude, K., Nait‐Oumesmar, B., Liblau, R., Pham-Dinh, D., & Evercooren, A. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192314199 · Cited by 469 · see citing works
Pringle, N. P., Mudhar, H. S., Collarini, E. J., & Richardson, W. D. (1992) · Development · doi:10.1242/dev.115.2.535 · Cited by 442 · see citing works
Hevner, R. F., Hodge, R. D., Daza, R. A. M., & Englund, C. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.03.004 · Cited by 438 · see citing works
Hematopoietic Cytokines Can Instruct Lineage Choice
Rieger, M. A., Hoppe, P. S., Smejkal, B. M., Eitelhuber, A. C., & Schroeder, T. (2009) · Science · doi:10.1126/science.1171461 · Cited by 404 · see citing works
Self-citationMori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398 · see citing works
Pastrana, É., Cheng, L.-C., & Doetsch, F. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810407106 · Cited by 381 · see citing works
Adult generation of glutamatergic olfactory bulb interneurons
Brill, M. S., Ninkovic, J., Winpenny, E. M., Hodge, R. D., Ozen, I., Yang, R., Lepier, A., Gascón, S., Erdélyi, F., Szabó, G., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2416 · Cited by 364 · see citing works
Self-citationLake-Front Property: A Unique Germinal Niche by the Lateral Ventricles of the Adult Brain
Ihrie, R. A., & Álvarez-Buylla, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.004 · Cited by 346 · see citing works
Snapyan, M., Lemasson, M., Brill, M. S., Blais, M., Massouh, M., Ninkovic, J., Gravel, C., Berthod, F., Götz, M., Barker, P. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4956-08.2009 · Cited by 346 · see citing works
Nakamura, T., Colbert, M. C., & Robbins, J. M. (2006) · Circulation Research · doi:10.1161/01.res.0000227505.19472.69 · Cited by 343 · see citing works
Beckervordersandforth, R., Tripathi, P., Ninkovic, J., Bayam, E., Lepier, A., Stempfhuber, B., Kirchhoff, F., Hirrlinger, J., Haslinger, A., Lie, D. C., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.017 · Cited by 335 · see citing works
Gabay, L., Lowell, S., Lee, R.-B. L., & Anderson, D. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00637-8 · Cited by 326 · see citing works
Simon, C., Götz, M., & Dimou, L. (2011) · Glia · doi:10.1002/glia.21156 · Cited by 313 · see citing works
Self-citationLentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway
Fuerer, C., & Nusse, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009370 · Cited by 287 · see citing works
Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells
Colak, D., Mori, T., Brill, M. S., Pfeifer, A., Falk, S., Deng, C., Monteiro, R. M., Mummery, C. L., Sommer, L., & Götz, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4374-07.2008 · Cited by 264 · see citing works
Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity
Ihrie, R. A., Shah, J. K., Harwell, C. C., Levine, J. H., Guinto, C. D., Lezameta, M., Kriegstein, A. R., & Alvarez-Buylla, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.018 · Cited by 255 · see citing works
González-Pérez, Ó., Romero-Rodriguez, R., Soriano‐Navarro, M., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2009) · Stem Cells · doi:10.1002/stem.119 · Cited by 217 · see citing works
Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination
Jablonska, B., Aguirre, A. A., Raymond, M., Szabó, G., Kitabatake, Y., Sailor, K. A., Ming, G., Song, H., & Gallo, V. (2010) · Nature Neuroscience · doi:10.1038/nn.2536 · Cited by 215 · see citing works
Brill, M. S., Snapyan, M., Wohlfrom, H., Ninkovic, J., Jawerka, M., Mastick, G. S., Ashery‐Padan, R., Saghatelyan, A., Berninger, B., & Götz, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0700-08.2008 · Cited by 212 · see citing works
Self-citationIdentity, distribution, and development of polydendrocytes: NG2-expressing glial cells
Nishiyama, A., Watanabe, M., Yang, Z., & Bu, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025783412651 · Cited by 211 · see citing works
Costa, M. R., Wen, G., Lepier, A., Schroeder, T., & Götz, M. (2007) · Development · doi:10.1242/dev.009951 · Cited by 208 · see citing works
Self-citationLong-term single-cell imaging of mammalian stem cells
Schroeder, T. (2011) · Nature Methods · doi:10.1038/nmeth.1577 · Cited by 171 · see citing works
Self-citationOligodendrogenesis in the subventricular zone and the role of epidermal growth factor
González-Pérez, Ó., & Álvarez-Buylla, A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.001 · Cited by 168 · see citing works
Expression of reef coral fluorescent proteins in the central nervous system of transgenic mice
Hirrlinger, P. G., Scheller, A., Braun, C., Quintela-Schneider, M., Fuss, B., Hirrlinger, J., & Kirchhoff, F. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.08.011 · Cited by 165 · see citing works
Continuous live imaging of adult neural stem cell division and lineage progression in vitro
Costa, M. R., Ortega, F., Brill, M. S., Beckervordersandforth, R., Petrone, C., Schroeder, T., Götz, M., & Berninger, B. (2011) · Development · doi:10.1242/dev.061663 · Cited by 159 · see citing works
Self-citationWnt signaling is sufficient to perturb oligodendrocyte maturation
Feigenson, K. A., Reid, M., See, J. M., Crenshaw, E. B., & Grinspan, J. B. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.07.010 · Cited by 157 · see citing works
Production of neurons, astrocytes and oligodendrocytes from mammalian CNS stem cells
Chojnacki, A. K., & Weiss, S. (2008) · Nature Protocols · doi:10.1038/nprot.2008.55 · Cited by 155 · see citing works
Phosphorylation Regulates OLIG2 Cofactor Choice and the Motor Neuron-Oligodendrocyte Fate Switch
Li, H., de Faria, J. P., Andrew, P., Nitarska, J., & Richardson, W. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.030 · Cited by 127 · see citing works
Sox17 regulates the Wnt/beta-catenin signaling pathway in oligodendrocyte progenitor cells
Chew, L., Shen, W., Ming, X., Senatorov, V., Chen, H., Cheng, Y., Hong, E., Knoblach, S., & Gallo, V. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3343-11.2011 · Cited by 96 · see citing works
Sox10‐iCreERT2: A mouse line to inducibly trace the neural crest and oligodendrocyte lineage
Simon, C., Lickert, H., Götz, M., & Dimou, L. (2011) · genesis · doi:10.1002/dvg.22003 · Cited by 87 · see citing works
Self-citationWnt signaling and neural stem cells: caught in the Wnt web
Michaelidis, T. M., & Lie, D. C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0476-5 · Cited by 80 · see citing works
Aguirre, A. A., & Gallo, V. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000082 · Cited by 78 · see citing works
White, B. D., Nathe, R. J., Maris, D. O., Nguyen, N. K., Goodson, J. M., Moon, R. T., & Horner, P. J. (2009) · Stem Cells · doi:10.1002/stem.268 · Cited by 74 · see citing works
Prospective isolation of adult neural stem cells from the mouse subependymal zone
Fischer, J., Beckervordersandforth, R., Tripathi, P., Steiner-Mezzadri, A., Ninkovic, J., & Götz, M. (2011) · Nature Protocols · doi:10.1038/nprot.2011.412 · Cited by 71 · see citing works
Self-citationMatsumoto, Y., Tsunekawa, Y., Nomura, T., Suto, F., Matsumata, M., Tsuchiya, S., & Osumi, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027628 · Cited by 64 · see citing works
Langseth, A. J., Munji, R. N., Choe, Y., Huynh, T., Pozniak, C. D., & Pleasure, S. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1934-10.2010 · Cited by 63 · see citing works
Ortega, F., Costa, M. R., Simon‐Ebert, T., Schroeder, T., Götz, M., & Berninger, B. (2011) · Nature Protocols · doi:10.1038/nprot.2011.404 · Cited by 48 · see citing works
Self-citationRole of blood vessels in the neuronal migration
Saghatelyan, A. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.04.006 · Cited by 39 · see citing works
Wnt Signaling Has Opposing Roles in the Developing and the Adult Brain That Are Modulated by Hipk1
Marinaro, C., Pannese, M., Weinandy, F., Sessa, A., Bergamaschi, A., Taketo, M. M., Broccoli, V., Comı, G., Götz, M., Martino, G., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr320 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791 · see citing works
Llorens-Bobadilla, E., Zhao, S., Baser, A., Saiz-Castro, G., Zwadlo, K., & Martin-Villalba, A. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.07.002 · Cited by 778 · see citing works
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634 · see citing works
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works
Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone
Shigemoto‐Mogami, Y., Hoshikawa, K., Goldman, J. E., Sekino, Y., & Sato, K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1619-13.2014 · Cited by 499 · see citing works
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Kalamakis, G., Brüne, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., Stiehl, T., Catalá-Martinez, F., Kupke, J., Zhao, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.040 · Cited by 399 · see citing works
Self-citationAge-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells
Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P., & Doetsch, F. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.013 · Cited by 306 · see citing works
Xing, Y. L., Röth, P. T., Stratton, J. A. S., Chuang, B. H. A., Danne, J., Ellis, S. L., Ng, S. W., Kilpatrick, T. J., & Merson, T. D. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3491-13.2014 · Cited by 275 · see citing works
NG 2‐glia and their functions in the central nervous system
Dimou, L., & Gallo, V. (2015) · Glia · doi:10.1002/glia.22859 · Cited by 258 · see citing works
Self-citationSingle-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages
Mizrak, D., Levitin, H. M., Delgado, A. C., Crotet, V., Yuan, J., Chaker, Z., Silva-Vargas, V., Sims, P. A., & Doetsch, F. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.044 · Cited by 248 · see citing works
Aging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246 · see citing works
Götz, M., Sirko, S., Beckers, J., & Irmler, M. (2015) · Glia · doi:10.1002/glia.22850 · Cited by 219 · see citing works
Intracellular signaling pathway regulation of myelination and remyelination in the CNS
Gaesser, J. M., & Fyffe-Maricich, S. L. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.008 · Cited by 208 · see citing works
Ramakrishna, K., Nalla, L. V., Dumala, N., Venkateswarlu, K., Viswanadh, M. K., Nalluri, B. N., Chakravarthy, G., Duguluri, S., Singh, P., Nand, S., et al. (2023) · Diseases · doi:10.3390/diseases11030089 · Cited by 203 · see citing works
A mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198 · see citing works
Effects of Microglia on Neurogenesis
Sato, K. (2015) · Glia · doi:10.1002/glia.22858 · Cited by 187 · see citing works
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186 · see citing works
Adult neural stem cells stake their ground
Lim, D. A., & Álvarez-Buylla, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.006 · Cited by 179 · see citing works
Oligodendrogenesis in the normal and pathological central nervous system
Waly, B. E., Macchi, M., Cayre, M., & Durbec, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00145 · Cited by 176 · see citing works
NG2 Cells in White Matter But Not Gray Matter Proliferate in Response to PDGF
Hill, R., Patel, K. D., Medved, J., Reiss, A., & Nishiyama, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2001-12.2013 · Cited by 165 · see citing works
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
Bengoa‐Vergniory, N., & Kypta, R. M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2028-6 · Cited by 161 · see citing works
Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia
Wang, F., Cao, Y., Ma, L., Pei, H., Rausch, W., & Li, H. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00376 · Cited by 160 · see citing works
Software tools for single-cell tracking and quantification of cellular and molecular properties
Hilsenbeck, O., Schwarzfischer, M., Skylaki, S., Schauberger, B., Hoppe, P. S., Loeffler, D., Kokkaliaris, K. D., Hastreiter, S., Skylaki, E., Filipczyk, A. A., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3626 · Cited by 159 · see citing works
Self-citationWhite matter injury in infants with intraventricular haemorrhage: mechanisms and therapies
Ballabh, P., & de Vries, L. S. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00447-8 · Cited by 159 · see citing works
Han, L., Cai, W., Mao, L., Liu, J., Li, P., Leak, R. K., Xu, Y., Hu, X., & Chen, J. (2015) · Stroke · doi:10.1161/strokeaha.115.010091 · Cited by 155 · see citing works
Endogenous neural stem cell responses to stroke and spinal cord injury
Grégoire, C., Goldenstein, B., Floriddia, E. M., Barnabé‐Heider, F., & Fernandes, K. J. L. (2015) · Glia · doi:10.1002/glia.22851 · Cited by 152 · see citing works
Oligodendrogenesis after cerebral ischemia
Zhang, R., Chopp, M., & Zhang, Z. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00201 · Cited by 149 · see citing works
Neurogenesis in the Developing and Adult Brain—Similarities and Key DifferencesPreprint
Götz, M., Nakafuku, M., & Petřík, D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018853 · Cited by 131 · see citing works
Redmond, S., Figueres‐Oñate, M., Obernier, K., Nascimento, M. A., Parraguez, J. I., López‐Mascaraque, L., Fuentealba, L. C., & Álvarez-Buylla, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.088 · Cited by 128 · see citing works
Dulamea, A. O. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-47861-6_7 · Cited by 128 · see citing works
Agoston, Z., Heine, P., Brill, M. S., Grebbin, B. M., Hau, A., Kallenborn-Gerhardt, W., Schramm, J., Götz, M., & Schulte, D. (2013) · Development · doi:10.1242/dev.097295 · Cited by 123 · see citing works
Lineage, fate, and fate potential of NG2-glia
Nishiyama, A., Boshans, L. L., Gonçalves, C. M., Wegrzyn, J., & Patel, K. D. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.013 · Cited by 120 · see citing works
NG2 cells (polydendrocytes): Listeners to the neural network with diverse properties
Hill, R., & Nishiyama, A. (2014) · Glia · doi:10.1002/glia.22664 · Cited by 117 · see citing works
Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis
Fiorelli, R., Azim, K., Fischer, B., & Raineteau, O. (2015) · Development · doi:10.1242/dev.119966 · Cited by 116 · see citing works
Stage-Specific Regulation of Oligodendrocyte Development by Wnt/ -Catenin Signaling
Dai, Z., Sun, S., Wang, C., Huang, H., Hu, X., Zhang, Z., Lu, Q. R., & Qiu, M. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0311-14.2014 · Cited by 114 · see citing works
The Molecular Basis for Remyelination Failure in Multiple Sclerosis
Gruchot, J., Weyers, V., Göttle, P., Förster, M., Hartung, H., Küry, P., & Kremer, D. (2019) · Cells · doi:10.3390/cells8080825 · Cited by 109 · see citing works
NG2 cells (polydendrocytes) in brain physiology and repair
Nishiyama, A., Suzuki, R., & Zhu, X. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00133 · Cited by 108 · see citing works
Canonical Wnt signaling in the oligodendroglial lineage-puzzles remain
Guo, F., Lang, J., Sohn, J., Hammond, E., Chang, M., & Pleasure, D. (2015) · Glia · doi:10.1002/glia.22813 · Cited by 107 · see citing works
Single-cell technologies sharpen up mammalian stem cell research
Hoppe, P. S., Coutu, D. L., & Schroeder, T. (2014) · Nature Cell Biology · doi:10.1038/ncb3042 · Cited by 104 · see citing works
Self-citationRodriguez, J. P., Coulter, M., Miotke, J., Meyer, R., Takemaru, K., & Levine, J. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4915-13.2014 · Cited by 102 · see citing works
Maki, T., Liang, A. C., Miyamoto, N., Lo, E. H., & Arai, K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00275 · Cited by 99 · see citing works
Falk, S., & Götz, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.025 · Cited by 99 · see citing works
Therapeutic Plasticity of Neural Stem Cells
Ottoboni, L., von Wunster, B., & Martino, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00148 · Cited by 98 · see citing works
MicroRNA-146a Promotes Oligodendrogenesis in Stroke
Liu, X., Chopp, M., Pan, W. L., Wang, X. L., Fan, B. Y., Zhang, Y., Kassis, H., Zhang, R. L., Zhang, X. M., & Zhang, Z. G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9655-7 · Cited by 96 · see citing works
Brousse, B., Magalon, K., Durbec, P., & Cayre, M. (2015) · Biology Open · doi:10.1242/bio.012773 · Cited by 91 · see citing works
Azim, K., Fischer, B., Hurtado‐Chong, A., Draganova, K., Cantù, C., Zemke, M., Sommer, L., Butt, A., & Raineteau, O. (2014) · Stem Cells · doi:10.1002/stem.1639 · Cited by 88 · see citing works
Chamberlain, K. A., Nanescu, S. E., Psachoulia, K., & Huang, J. K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.010 · Cited by 88 · see citing works
Chavali, M., Klingener, M., Kokkosis, A. G., Garkun, Y., Felong, S., Maffei, A., & Aguirre, A. A. (2017) · Nature Communications · doi:10.1038/s41467-017-02440-0 · Cited by 85 · see citing works
Gengatharan, A., Bammann, R. R., & Saghatelyan, A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00149 · Cited by 81 · see citing works
Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair
Gilbert, E. A. B., Lakshman, N., Lau, K. S. K., & Morshead, C. M. (2022) · Cells · doi:10.3390/cells11050846 · Cited by 80 · see citing works
Kyle, J., Wu, M. W., Gourzi, S., & Tsirka, S. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00097 · Cited by 79 · see citing works
Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re)myelination
Thomas, L., & Pasquini, L. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00297 · Cited by 76 · see citing works
The heterogeneous nature of NG2-glia
Viganò, F., & Dimou, L. (2015) · Brain Research · doi:10.1016/j.brainres.2015.09.012 · Cited by 72 · see citing works
Self-citationUncovering the roles of long noncoding RNAs in neural development and glioma progression
Ramos, A. D., Attenello, F. J., & Lim, D. A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.025 · Cited by 70 · see citing works
More Than Mortar: Glia as Architects of Nervous System Development and Disease
Lago‐Baldaia, I., Fernandes, V. M., & Ackerman, S. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.611269 · Cited by 68 · see citing works
Choi, J. Y., Kim, J. Y., Kim, J. Y., Park, J., Lee, W. T., & Lee, J. E. (2017) · Experimental Neurobiology · doi:10.5607/en.2017.26.1.33 · Cited by 68 · see citing works
Butti, E., Bacigaluppi, M., Chaabane, L., Ruffini, F., Brambilla, E., Berera, G., Montonati, C., Quattrini, A., & Martino, G. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0227-18.2019 · Cited by 67 · see citing works
Hu, X.-L., Chen, G., Zhang, S., Zheng, J., Wu, J., Bai, Q., Wang, Y., Li, J., Wang, H., Han, F., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.047 · Cited by 66 · see citing works
Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration
López‐Juárez, A., He, D., & Lu, Q. R. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.051 · Cited by 63 · see citing works
Rivera, A. D., Pieropan, F., Chacon‐De‐La‐Rocha, I., Lecca, D., Abbracchio, M. P., Azim, K., & Butt, A. M. (2021) · Aging Cell · doi:10.1111/acel.13335 · Cited by 61 · see citing works
Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury
Sun, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.017 · Cited by 60 · see citing works
Conserved and Divergent Features of Adult Neurogenesis in Zebrafish
Labusch, M., Mancini, L., Morizet, D., & Bally‐Cuif, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00525 · Cited by 60 · see citing works
Mizrak, D., Bayin, N. S., Yuan, J., Liu, Z., Suciu, R. M., Niphakis, M. J., Ngo, N., Lum, K. M., Cravatt, B. F., Joyner, A. L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107805 · Cited by 59 · see citing works
Microenvironments Designed to Support Growth and Function of Neuronal Cells
Farrukh, A., Zhao, S., & del Campo, A. (2018) · Frontiers in Materials · doi:10.3389/fmats.2018.00062 · Cited by 58 · see citing works
Shindo, A., Liang, A. C., Maki, T., Miyamoto, N., Tomimoto, H., Lo, E. H., & Arai, K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.80 · Cited by 58 · see citing works
DNA methylation controls stemness of astrocytes in health and ischaemia
Kremer, L. P. M., Cerrizuela, S., El‐Sammak, H., Shukairi, M. E. A., Ellinger, T., Straub, J., Korkmaz, A., Volk, K., Brunken, J., Kleber, S., et al. (2024) · Nature · doi:10.1038/s41586-024-07898-9 · Cited by 57 · see citing works
The axon–glia unit in white matter stroke: Mechanisms of damage and recovery
Rosenzweig, S., & Carmichael, S. T. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.019 · Cited by 56 · see citing works
Wnt Signaling in Remyelination in Multiple Sclerosis: Friend or Foe?
Xie, C., Li, Z., Zhang, G., & Guan, Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8584-6 · Cited by 55 · see citing works
Notching up neural stem cell homogeneity in homeostasis and disease
Giachino, C., & Taylor, V. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00032 · Cited by 55 · see citing works
Azim, K., Angonin, D., Marcy, G., Pieropan, F., Rivera, A. D., Donega, V., Cantù, C., Williams, G. H., Berninger, B., Butt, A. M., et al. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2000698 · Cited by 55 · see citing works
Self-citationTargeting human oligodendrocyte progenitors for myelin repair
Dietz, K. C., Polanco, J. J., Pol, S. U., & Sim, F. J. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.017 · Cited by 54 · see citing works
Targeting Adult Neurogenesis for Poststroke Therapy
Lu, J., Manaenko, A., & Hu, Q. (2017) · Stem Cells International · doi:10.1155/2017/5868632 · Cited by 54 · see citing works
Pbx1 is required for adult SVZ neurogenesis
Grebbin, B. M., Hau, A., Groß, A., Anders-Maurer, M., Schramm, J., Koss, M., Wille, C., Mittelbronn, M. G. A., Selleri, L., & Schulte, D. (2016) · Development · doi:10.1242/dev.128033 · Cited by 52 · see citing works
Azim, K., Rivera, A. D., Raineteau, O., & Butt, A. M. (2014) · Glia · doi:10.1002/glia.22641 · Cited by 51 · see citing works
Roles of NG 2‐glia in ischemic stroke
Song, F., Huang, J., Lin, S., Wang, S., Ma, G., & Tong, X. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12690 · Cited by 51 · see citing works
Thyroid hormone regulation of neural stem cell fate: From development to ageing
Gothié, J. M., Vancamp, P., DEMENEIX, B. A., & Remaud, S. (2019) · Acta Physiologica · doi:10.1111/apha.13316 · Cited by 51 · see citing works
Neural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche
Morante‐Redolat, J. M., & Porlan, E. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00102 · Cited by 50 · see citing works
Diversity of Neural Precursors in the Adult Mammalian BrainPreprint
Bonaguidi, M. A., Stadel, R. P., Berg, D. A., Sun, J., Ming, G., & Song, H. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018838 · Cited by 50 · see citing works
Klingener, M., Chavali, M., Singh, J., McMillan, N., Coomes, A. S., Dempsey, P. J., Chen, E. I., & Aguirre, A. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3699-13.2014 · Cited by 48 · see citing works
RetractedDulămea, A. O. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.221146 · Cited by 48 · see citing works
Ontogeny of adult neural stem cells in the mammalian brain
Bond, A. M., Ming, G., & Song, H. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.002 · Cited by 48 · see citing works
Magnusson, J. P., & Frisén, J. (2016) · Development · doi:10.1242/dev.133975 · Cited by 46 · see citing works
Kazanis, I., Evans, K. A., Andreopoulou, E., Dimitriou, C., Koutsakis, C., Káradóttir, R. T., & Franklin, R. J. M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.01.007 · Cited by 46 · see citing works
Apostolopoulou, M., Kiehl, T. R., Winter, M. R., Hoz, E. C. D. L., Boles, N. C., Bjornsson, C. S., Zuloaga, K. L., Goderie, S. K., Wang, Y., Cohen, A. R., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.005 · Cited by 45 · see citing works
Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis
Jiang, X., Guan, Y., Zhao, Z., Meng, F., Wang, X., Gao, X., Liu, J., Chen, Y., Zhou, F., Zhou, F., et al. (2021) · Cells · doi:10.3390/cells10040839 · Cited by 45 · see citing works
Adult NSC diversity and plasticity: the role of the niche
Llorens-Bobadilla, E., & Martín-Villalba, A. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.008 · Cited by 43 · see citing works
Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
Sun, G. J., Zhou, Y. F., Ito, S., Bonaguidi, M. A., Stein-O’Brien, G., Kawasaki, N. K., Modak, N., Zhu, Y., Ming, G., & Song, H. (2015) · Nature Neuroscience · doi:10.1038/nn.4159 · Cited by 41 · see citing works
Yin, L., Ma, H., Chen, T., Yu, Y., Tang, L., Kong, L., Zhang, C., & Chu, H. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202947 · Cited by 40 · see citing works
Wong, A. W., Giuffrida, L., Wood, R., Peckham, H., Gonsalvez, D., Murray, S. S., Hughes, R. A., & Xiao, J. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.10.002 · Cited by 39 · see citing works
Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ
Khatri, P., Obernier, K., Simeonova, I. K., Hellwig, A., Hölzl‐Wenig, G., Mandl, C., Scholl, C., Wölfl, S., Winkler, J., Gaspar, J. A., et al. (2014) · Scientific Reports · doi:10.1038/srep03803 · Cited by 39 · see citing works
SnapShot: Adult Neurogenesis in the V-SVZ
Tong, C. K., & Álvarez-Buylla, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.004 · Cited by 38 · see citing works
Serwanski, D., Rasmussen, A., Brunquell, C., Perkins, S., & Nishiyama, A. (2018) · Neuroglia · doi:10.3390/neuroglia1010008 · Cited by 38 · see citing works
Platel, J., & Bordey, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.053 · Cited by 38 · see citing works
Lineage Tracing and Cell Potential of Postnatal Single Progenitor Cells In Vivo
Figueres‐Oñate, M., Sánchez-Villalón, M., Sánchez‐González, R., & López‐Mascaraque, L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.08.010 · Cited by 37 · see citing works
Bicker, F., Vasić, V., Horta, G., Ortega, F., Nolte, H., Kavyanifar, A., Keller, S., Stanković, N. D., Harter, P. N., Benedito, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms15922 · Cited by 36 · see citing works
Self-citationThe environment rules: spatiotemporal regulation of oligodendrocyte differentiation
Mayoral, S. R., & Chan, J. R. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.04.002 · Cited by 35 · see citing works
Cell Fate Potential of NG2 Progenitors
Sánchez‐González, R., Bribián, A., & López‐Mascaraque, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-66753-9 · Cited by 35 · see citing works
Knotek, T., Janečková, L., Kriška, J., Kořínek, V., & Anděrová, M. (2020) · Genes · doi:10.3390/genes11070804 · Cited by 35 · see citing works
Role of Astrocytes in the Neurogenic Niches
Schneider, J., Karpf, J., & Beckervordersandforth, R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_2 · Cited by 34 · see citing works
History of Neural Stem Cell Research and Its Clinical Application
Takagi, Y. (2016) · Neurologia medico-chirurgica · doi:10.2176/nmc.ra.2015-0340 · Cited by 33 · see citing works
- Authors
- Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B.
- Affiliations
- Physiologisches Institut (DE)
- Helmholtz Munich (DE)
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Ortega, Felipe
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2013-05-05
- Volume
- 15
- Issue
- 6
- Pages
- 602-613
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2055055895
- Cited by
- 247
- References
- 55
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 22 · 2020: 24 · 2019: 26 · 2018: 21 · 2017: 27 · 2016: 27 · 2015: 25 · 2014: 23 · 2013: 7
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neural stem cells, subventricular zone, neurogenesis, lineage choice, Wnt signaling, Wnt/β-catenin signaling, stem cell proliferation, Olig2, PDGFRA, single-cell tracking, live imaging
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Cell Cycle, Cell Differentiation, Cell Division, Cells, Cultured, Central Nervous System, Female, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Oligodendroglia, Cell Lineage, Receptor, Platelet-Derived Growth Factor alpha, Cell Proliferation, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Neural Stem Cells, Wnt Signaling Pathway, Wnt3 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review