Cited by 247Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroinflammation and Neurodegeneration Mechanisms

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

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Ortega, Felipe, Gascón, Sergio, Masserdotti, Giacomo, Deshpande, Aditi, Simon, Christiane, Fischer, Judith, Dimou, Leda, Chichung Lie, D. +2 more·2013·Nature Cell Biology

Abstract

The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that give rise to neuronal and oligodendroglial progeny. However it is not known whether the same aNSC can give rise to neuronal and oligodendroglial progeny or whether these distinct progenies constitute entirely separate lineages. Continuous live imaging and single-cell tracking of aNSCs and their progeny isolated from the mouse SEZ revealed that aNSCs exclusively generate oligodendroglia or neurons, but never both within a single lineage. Moreover, activation of canonical Wnt signalling selectively stimulated proliferation within the oligodendrogliogenic lineage, resulting in a massive increase in oligodendrogliogenesis without changing lineage choice or proliferation within neurogenic clones. In vivo activation or inhibition of canonical Wnt signalling respectively increased or decreased the number of Olig2 and PDGFR- α positive cells, suggesting that this pathway contributes to the fine tuning of oligodendrogliogenesis in the adult SEZ.

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  • Oligodendrocytes and astrocytes are also generated in the adult V-SVZ.

    “Although oligodendrocytes and astrocytes are also generated in the adult V-SVZ (Menn et al., 2006; Nait-Oumesmar et al., 1999; Ortega et al., 2013; Sohn et al., 2015; Xing et al., 2014), their lineage trajectories are less clear.”

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Authors
Ortega, F., Gascón, S., Masserdotti, G., Deshpande, A., Simon, C., Fischer, J., Dimou, L., Chichung Lie, D., Schroeder, T., & Berninger, B.
Affiliations
  • Physiologisches Institut (DE)
  • Helmholtz Munich (DE)
  • Johannes Gutenberg University Mainz (DE)
Corresponding author
Ortega, Felipe
Venue
Nature Cell Biology
Published
2013-05-05
Volume
15
Issue
6
Pages
602-613
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2055055895
Cited by
247
References
55
Citations by year
2026: 1 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 22 · 2020: 24 · 2019: 26 · 2018: 21 · 2017: 27 · 2016: 27 · 2015: 25 · 2014: 23 · 2013: 7
FWCI
10.15
Type
journal article
Language
en
Open access
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
  • Site cant be reached (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
adult neural stem cells, subventricular zone, neurogenesis, lineage choice, Wnt signaling, Wnt/β-catenin signaling, stem cell proliferation, Olig2, PDGFRA, single-cell tracking, live imaging
MeSH terms
Oligodendrocyte Transcription Factor 2, Animals, Cell Cycle, Cell Differentiation, Cell Division, Cells, Cultured, Central Nervous System, Female, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Oligodendroglia, Cell Lineage, Receptor, Platelet-Derived Growth Factor alpha, Cell Proliferation, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Neural Stem Cells, Wnt Signaling Pathway, Wnt3 Protein

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