Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling
Abstract
Hepatic carcinoma is one of the most common cancers in the world, with a high incidence. Emodin is an anthraquinone derived from Polygonum multiflorum Thunb, possessing anti-cancer activity. The purpose of this study is to investigate the anti-cancer effect of different dosages of emodin on HepG2 cells using a 1 H NMR based metabolic approach complemented with qRT-PCR and flow cytometry to identify potential markers and discover the targets to explore the underlying mechanism. Emodin can dose-dependently inhibit the growth of HepG2 cells, perturb cell cycle progression, down-regulate the expression of genes and proteins related to glycolysis, and trigger intracellular ROS generation. Orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) and correlation network analysis of the 1 H NMR data showed significant changes in many endogenous metabolites after emodin exposure concerning oxidative stress and disturbances in amino acid and energy metabolism. These findings are helpful to understand the anti-cancer mechanism of emodin and provide a theoretical basis for its future application and development.
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The cytotoxic effects of emodin on HepG2 cells are associated with disruptions in metabolic homeostasis including oxidative stress and imbalances in amino acids.
“Furthermore, Xing et al. demonstrated that the cytotoxic effects of emodin on HepG2 cells were associated with disruptions in metabolic homeostasis including oxidative stress and imbalances in amino acids.276”
From Drug repurposing for cancer therapy (2024) · cites this paper as [276]
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Self-citation
- Authors
- Xing, Y.-X., Li, M.-H., Tao, L., Ruan, L.-Y., Hong, W., Chen, C., Zhao, W.-L., Xu, H., Chen, J.-F., & Wang, J.-S.
- Affiliations
- Nanjing University of Science and Technology (CN)
- Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing 210094, People’s Republic of China
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-04-20
- Volume
- 17
- Issue
- 5
- Pages
- 1943-1952
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W2801588198
- Cited by
- 46
- References
- 40
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 11 · 2019: 3 · 2018: 3
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Proteome Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81773857)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- emodin, HepG2 cells, hepatocellular carcinoma, anthraquinones, Polygonum multiflorum, anticancer mechanism, cell cycle arrest, glycolysis, reactive oxygen species, oxidative stress, amino acid metabolism, energy metabolism, endogenous metabolites, dose-dependent cytotoxicity
- MeSH terms
- Amino Acids, Antineoplastic Agents, Emodin, Energy Metabolism, Flow Cytometry, Humans, Biomarkers, Polymerase Chain Reaction, Oxidative Stress, Protein Kinase Inhibitors, Metabolome, Hep G2 Cells, Proton Magnetic Resonance Spectroscopy
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