Toward Completion of the Human Proteome Parts List: Progress Uncovering Proteins That Are Missing or Have Unknown Function and Developing Analytical Methods
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ADVERTISEMENT RETURN TO ISSUEEditorialNEXTToward Completion of the Human Proteome Parts List: Progress Uncovering Proteins That Are Missing or Have Unknown Function and Developing Analytical MethodsYoung-Ki Paik*Young-Ki PaikYonsei Proteome Research Center, College of Life Science and Technology, Yonsei University*Y.-K.P.: E-mail: [email protected]More by Young-Ki Paikhttp://orcid.org/0000-0002-8146-1751, Christopher M. OverallChristopher M. OverallCentre for Blood Research, Departments of Oral Biological & Medical Sciences and Biochemistry & Molecular Biology, Faculty of Dentistry, University of British ColumbiaMore by Christopher M. Overallhttp://orcid.org/0000-0001-5844-2731, Fernando CorralesFernando CorralesFunctional Proteomics Laboratory National Center of Biotechnology, CSICMore by Fernando Corrales, Eric W. DeutschEric W. DeutschInstitute for Systems BiologyMore by Eric W. Deutschhttp://orcid.org/0000-0001-8732-0928, Lydie LaneLydie LaneCALIPHO Group, SIB Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, Faculty of Medicine, CMU, University of GenevaMore by Lydie Lanehttp://orcid.org/0000-0002-9818-3030, and Gilbert S. Omenn*Gilbert S. OmennInstitute for Systems Biology, Departments of Computational Medicine & Bioinformatics, Internal Medicine, and Human Genetics & School of Public Health, University of Michigan*G.S.O.: E-mail: [email protected]More by Gilbert S. Omennhttp://orcid.org/0000-0002-8976-6074Cite this: J. Proteome Res. 2018, 17, 12, 4023–4030Publication Date (Web):December 7, 2018Publication History Published online7 December 2018Published inissue 7 December 2018https://pubs.acs.org/doi/10.1021/acs.jproteome.8b00885https://doi.org/10.1021/acs.jproteome.8b00885editorialACS PublicationsCopyright © 2018 American Chemical Society. This publication is licensed under these Terms of Use. Request reuse permissions This publication is Open Access under the license indicated. Learn MoreACS Editors' Choice® is a collection designed to feature scientific articles of broad public interest. Read the latest articlesArticle Views2134Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (806 KB) Get e-AlertscloseSUBJECTS:Genetics,Peptide identification,Peptides and proteins,Protein identification,Proteomics Get e-Alerts
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Many missing proteins may be present at levels below detection limits or in under-studied cell types/tissues, expressed under particular conditions (e.g., stress/infection) or only found in developmental stages (e.g., embryo/fetus).
“However, many missing proteins may be present at levels below detection limits or in under-studied cell types/tissues, expressed under particular conditions (e.g., stress/infection) or only found in developmental stages (e.g., embryo/fetus)77.”
From A high-stringency blueprint of the human proteome (2020) · cites this paper as [77]
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- Authors
- Paik, Y.-K., Overall, C. M., Corrales, F., Deutsch, E. W., Lane, L., & Omenn, G. S.
- Affiliations
- Yonsei University (KR)
- University of British Columbia (CA)
- Consejo Superior de Investigaciones Científicas (ES)
- Institute for Systems Biology (US)
- University of Geneva (CH)
- University of Michigan (US)
- Corresponding author
- Paik, Young-Ki
- Omenn, Gilbert S.
- ORCID
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-12-07
- Volume
- 17
- Issue
- 12
- Pages
- 4023-4030
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- PMC
- PMC6288998
- OpenAlex
- W2902294516
- Cited by
- 21
- References
- 41
- Citations by year
- 2024: 1 · 2023: 3 · 2020: 8 · 2019: 8 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Proteome Research (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by-nc)
- Funders
- National Institutes of Health (P30ES017885-01A1, U24CA210967)
- Canadian Institutes of Health Research (FDN148408)
- The Korean Ministry of Health and Welfare (HI13C2098, HI16C0257)
- Ministerio de Economía y Competitividad (PRB2-ISCIII, PT13/0001L, PRB3-ISCIII PT17/0019, SAF2014-5478-R)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Keywords
- human proteome, missing proteins, unknown function protein, protein discovery, proteomics pipeline, protein annotation, proteomics data integration, functional proteomics, proteomics data analysis, proteomics data interpretation
- MeSH terms
- Humans, Proteins, Computational Biology, Proteome, Databases, Protein, Molecular Sequence Annotation
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