The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy
Abstract
The tumor immunosuppressive microenvironment greatly limits the efficacy of immunotherapy. Tumor-associated macrophages (TAMs) are the most abundant immunosuppressive cells in the tumor microenvironment, which can inhibit the tumor after converting it to an M1-like phenotype. In addition, immunogenic cell death (ICD) can increase the amount of T lymphocytes in tumors, activating antineoplastic immunity. Herein, tumor-associated macrophage polarization therapy supplemented with PLGA-DOX (PDOX)-induced ICD is developed for cancer treatment. The nanoparticles/bacteria complex (Ec-PR848) is fabricated for tumor targeting and TAM polarization, and PLGA-R848 (PR848) are attached to the surface of Escherichia coli ( E. coli ) MG1655 via electrostatic absorption. The toll-like receptor 7/8 (TLR7/8) agonist resiquimod (R848) and E. coli can greatly polarize M2 macrophages to M1 macrophages, while PDOX-induced ICD can also impair the immunosuppression of the tumor microenvironment. This strategy shows that tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapeutic drugs can commendably enhance the efficacy of immunotherapy.
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Cites
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Targeting multidrug resistance in cancer
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Toll-like Receptors and the Control of Immunity
Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell · doi:10.1016/j.cell.2020.02.041 · Cited by 2,168
Tumour-targeting bacteria engineered to fight cancer
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Self-citationTargeted cancer immunotherapy with genetically engineered oncolytic Salmonella typhimurium
Guo, Y., Chen, Y., Liu, X., Min, J.-J., Tan, W., & Zheng, J. H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2019.10.033 · Cited by 124
Cited by
Wang, N., Wu, S., Huang, L., Hu, Y., He, X., He, J., Hu, B., Xu, Y., Rong, Y., Yuan, C., et al. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01117-x · Cited by 62
Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48
The Development of Live Microorganism-Based Oxygen Shuttles for Enhanced Hypoxic Tumor Therapy
Han, D., Zhang, X., Ma, Y., Yang, X., & Li, Z. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100517 · Cited by 25
Fariha, F. T. J., Fuad, M., Saha, C. S., Hossen, S., & Hossain, M. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-13315-6 · Cited by 1
Metadata
- Authors
- Wei, B., Pan, J., Yuan, R., Shao, B., Wang, Y., Guo, X., & Zhou, S.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-05-17
- Volume
- 21
- Issue
- 10
- Pages
- 4231-4240
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W3161317876
- Cited by
- 265
- References
- 7
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
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