Toll-like Receptors and the Control of Immunity

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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Origin and physiological roles of inflammation

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A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129 · see citing works

The Inflammasome

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works

Mutations affecting segment number and polarity in Drosophila

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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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Genome Regulation by Long Noncoding RNAs

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947 · see citing works

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888 · see citing works

Mammalian microRNAs predominantly act to decrease target mRNA levels

Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886 · see citing works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680 · see citing works

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

CpG motifs in bacterial DNA trigger direct B-cell activation

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Approaching the asymptote? Evolution and revolution in immunology.Preprint

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Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

A guide to immunometabolism for immunologists

O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315 · see citing works

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

IL-10 inhibits cytokine production by activated macrophages

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IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works

lincRNAs: Genomics, Evolution, and Mechanisms

Ulitsky, I., & Bartel, D. P. (2013) · Cell · doi:10.1016/j.cell.2013.06.020 · Cited by 2,596 · see citing works

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,574 · see citing works

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,517 · see citing works

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Park, B., Song, D., Kim, H. M., Choi, B.-S., Lee, H., & Lee, J.-O. (2009) · Nature · doi:10.1038/nature07830 · Cited by 2,421 · see citing works

Unresponsiveness of MyD88-deficient mice to endotoxin.

Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367 · see citing works

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309 · see citing works

IRF-7 is the master regulator of type-I interferon-dependent immune responses

Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N., et al. (2005) · Nature · doi:10.1038/nature03464 · Cited by 2,229 · see citing works

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224 · see citing works

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223 · see citing works

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., & Chen, Z. J. (2001) · Nature · doi:10.1038/35085597 · Cited by 2,125 · see citing works

A family of human receptors structurally related to Drosophila Toll.

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y.-T., Grishin, N. V., et al. (2015) · Science · doi:10.1126/science.aaa2630 · Cited by 1,927 · see citing works

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

Hornung, V., Rothenfußer, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S., & Hartmann, G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4531 · Cited by 1,927 · see citing works

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,899 · see citing works

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728 · see citing works

Immunometabolism governs dendritic cell and macrophage function

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Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,664 · see citing works

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

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The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585 · see citing works

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )

Qureshi, S. T., Larivière, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., & Malo, D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.615 · Cited by 1,525 · see citing works

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works

Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S., Lee, H., & Lee, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.008 · Cited by 1,352 · see citing works

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works

Gene-specific control of inflammation by TLR-induced chromatin modifications

Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344 · see citing works

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.10 · Cited by 1,328 · see citing works

TRAF6 is a signal transducer for interleukin-1

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Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289 · see citing works

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

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Vaccination greatly reduces disease, disability, death and inequity worldwide

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,256 · see citing works

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,253 · see citing works

Discrimination of bacterial lipoproteins by Toll-like receptor 6

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LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B. G., Pitha, P. M., & Golenbock, D. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031023 · Cited by 1,193 · see citing works

TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R. A., Diamond, M., & Colonna, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603082103 · Cited by 1,156 · see citing works

Helical Assembly in the MyD88-IRAK4-IRAK2 Complex in TLR/IL-1R Signalling

Lin, S.-C., Lo, Y.-C., & Wu, H. (2010) · Nature · doi:10.1038/nature09121 · Cited by 1,111 · see citing works

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

Li, K., Foy, E. M., Ferreon, J. C., Nakamura, M., Ferreon, A. C. M., Ikeda, M., Ray, S. C., Gale, M., & Lemon, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408824102 · Cited by 1,092 · see citing works

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

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TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

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TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

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TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

Takaoka, A., Yanai, H., Kondo, S., Duncan, G. S., Negishi, H., Mizutani, T., Kano, S., Honda, K., Ohba, Y., Mak, T. W., et al. (2005) · Nature · doi:10.1038/nature03308 · Cited by 1,042 · see citing works

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

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Signaling via the NFκB system

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Necroptosis in development, inflammation and disease

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CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

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TIRAP: an adapter molecule in the Toll signaling pathway

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

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Toll-like receptor 3 promotes cross-priming to virus-infected cells

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Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

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IRAK: A Kinase Associated with the Interleukin-1 Receptor

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Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

Trowbridge, J. J., & Starczynowski, D. T. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201544 · Cited by 189 · see citing works

OMV Vaccines and the Role of TLR Agonists in Immune Response

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Dendritic cell maturation in cancer

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Direct activation of a bacterial innate immune system by a viral capsid protein

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A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2/NLRP3-Mediated M1-Like TAMs

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Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

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Targeting macrophages in hematological malignancies: recent advances and future directions

Li, W., Wang, F., Guo, R., Bian, Z., & Song, Y. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01328-x · Cited by 172 · see citing works

Advances in the study of macrophage polarization in inflammatory immune skin diseases

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Histone lactylation: from tumor lactate metabolism to epigenetic regulation

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Inducible antibacterial responses in macrophages

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COVID 19: a clue from innate immunity

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pH sensing at the intersection of tissue homeostasis and inflammation

Hajjar, S., & Zhou, X. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.008 · Cited by 157 · see citing works

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

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Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

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Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

Essuman, K., Milbrandt, J., Dangl, J. L., & Nishimura, M. T. (2022) · Science · doi:10.1126/science.abo0001 · Cited by 139 · see citing works

Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-κB signal in mice

Cao, J., Xu, R., Geng, Y., Xu, S., & Guo, M. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121068 · Cited by 152 · see citing works

Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?

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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial

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Control of adaptive immunity by pattern recognition receptors

Carroll, S. L., Pasare, C., & Barton, G. M. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.014 · Cited by 146 · see citing works

Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives

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Inflammaging: The ground for sarcopenia?

Liang, Z., Zhang, T., Liu, H., Li, Z., Peng, L., Wang, C., & Wang, T. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111931 · Cited by 141 · see citing works

Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes

Yang, Q., Zhang, H., Wei, T., Lin, A., Sun, Y., Luo, P., & Zhang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756722 · Cited by 141 · see citing works

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

Orzalli, M. H., Prochera, A., Payne, L., Smith, A., Garlick, J. A., & Kagan, J. C. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.012 · Cited by 137 · see citing works

Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex

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Necroptosis: A Novel Pathway in Neuroinflammation

Yu, Z., Jiang, N., Su, W., & Zhuo, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.701564 · Cited by 133 · see citing works

Tumor-Associated Macrophages: A Potential Target for Cancer Therapy

Tan, Y., Wang, M., Zhang, Y., Ge, S., Zhong, F., Xia, G., & Sun, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.693517 · Cited by 134 · see citing works

Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines

Sartorius, R., Trovato, M., Manco, R., D’Apice, L., & Berardinis, P. D. (2021) · npj Vaccines · doi:10.1038/s41541-021-00391-8 · Cited by 132 · see citing works

Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections

Gauthier, T., & Chen, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.780839 · Cited by 134 · see citing works

Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity

Dongye, Z., Li, J., & Wu, Y. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01876-6 · Cited by 135 · see citing works

DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

Chen, J., Wang, T., Li, X., Gao, L., Wang, K., Cheng, M., Zeng, Z., Chen, L., Shen, Y., & Wen, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01881-6 · Cited by 143 · see citing works

Regulation of innate immune signaling by IRAK proteins

Pereira, M. C. A., & Gazzinelli, R. T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133354 · Cited by 133 · see citing works

Mutual regulation of metabolic processes and proinflammatory NF-κB signaling

Kracht, M., Müller‐Ladner, U., & Schmitz, M. L. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.07.027 · Cited by 128 · see citing works

Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.

Huang, L., Lyu, Q., Zheng, W., Yang, Q., & Cao, G. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00482-7 · Cited by 128 · see citing works

Innate immune detection of lipid oxidation as a threat assessment strategy

Zhivaki, D., & Kagan, J. C. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00618-8 · Cited by 127 · see citing works

The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

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Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious Diseases

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Histone lactylation in macrophage biology and disease: from plasticity regulation to therapeutic implications

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Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists

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Probiotics and gut microbiota: mechanistic insights into gut immune homeostasis through TLR pathway regulation

Kaur, H., & Ali, S. A. (2022) · Food & Function · doi:10.1039/d2fo00911k · Cited by 121 · see citing works

STING trafficking as a new dimension of immune signaling

Jeltema, D., Abbott, K., & Yan, N. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20220990 · Cited by 116 · see citing works

The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies

Garcia, P., Wang, Y., Viallet, J. P., & Jílková, Z. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.791081 · Cited by 122 · see citing works

cGLRs are a diverse family of pattern recognition receptors in innate immunity

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Vaccine adjuvants: Tailoring innate recognition to send the right message

Lavelle, E. C., & McEntee, C. P. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.015 · Cited by 121 · see citing works

The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications

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MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization

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Role of TLRs as signaling cascades to combat infectious diseases: a review

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Toll-Like Receptor Signaling Pathways

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Toll-like Receptors are Key Participants in Innate Immune Responses

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Decoding Toll-like receptors: Recent insights and perspectives in innate immunity

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Review Article Toll-like receptors in innate immunity

Takeda, K., & Akira, S. (2013)