Transmembrane proteins of the tight junctions at the blood–brain barrier: Structural and functional aspects
Abstract
The blood-brain barrier (BBB) is formed by microvascular endothelial cells sealed by tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated marvel proteins, occludin and tricellulin). Claudins are the major components of the TJs. At the BBB, claudin-5 dominates the TJs by preventing the paracellular permeation of small molecules. On the other hand, TAMPs regulate the structure and function of the TJs; tricellulin may tighten the barrier for large molecules. This review aims at integrating and summarizing the most relevant and recent work on how the BBB is influenced by claudin-1, -3, -5, -12 and the TAMPs occludin and tricellulin, all of which are four-transmembrane TJ proteins. The exact functions of claudin-1, -3, -12 and TAMPs at this barrier still need to be elucidated.
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Claudins and occludins are major tight junction proteins; claudins display essential barrier function and occludins ensure tightness of tight junctions.
“Claudins and occludins that situate in two-cell contacts are the major tight junction proteins.95,96 Claudins display essential barrier function and occludins ensure the tightness of the tight junctions.97”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [95]
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The blood–brain barrier: Structure, regulation and drug delivery
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- Authors
- Haseloff, R. F., Dithmer, S., Winkler, L., Wolburg, H., & Blasig, I. E.
- Affiliations
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
- Corresponding author
- Blasig, Ingolf E.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 38
- Pages
- 16-25
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2079966013
- Cited by
- 353
- References
- 3
- Citations by year
- 2026: 19 · 2025: 27 · 2024: 28 · 2023: 34 · 2022: 35 · 2021: 31 · 2020: 32 · 2019: 31 · 2018: 31 · 2017: 39 · 2016: 30 · 2015: 16
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- BMBF (VIP0479)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- blood-brain barrier, tight junctions, claudins, claudin-5, claudin-1, claudin-3, claudin-12, occludin, tricellulin, paracellular permeability, endothelial tight junctions
- MeSH terms
- Animals, Biological Transport, Blood-Brain Barrier, Humans, Membrane Proteins, Tight Junctions, Endothelial Cells
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