Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent “Resting-State” Connectivity
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Resting-state signals in blood-oxygenation-level-dependent (BOLD) imaging are used to parcellate brain regions and define "functional connections" between regions. Yet a physiological link between fluctuations in blood oxygenation with those in neuronal signaling pathways is missing. We present evidence from studies on mouse cortex that modulation of vasomotion, i.e., intrinsic ultra-slow (0.1 Hz) fluctuations in arteriole diameter, provides this link. First, ultra-slow fluctuations in neuronal signaling, which occur as an envelope over γ-band activity, entrains vasomotion. Second, optogenetic manipulations confirm that entrainment is unidirectional. Third, co-fluctuations in the diameter of pairs of arterioles within the same hemisphere diminish to chance for separations >1.4 mm. Yet the diameters of arterioles in distant (>5 mm), mirrored transhemispheric sites strongly co-fluctuate; these correlations are diminished in acallosal mice. Fourth, fluctuations in arteriole diameter coherently drive fluctuations in blood oxygenation. Thus, entrainment of vasomotion links neuronal pathways to functional connections.
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The mean delays (around 1.5 s) found were somewhat shorter than the ones found in the above study (about 1.9-2 s)29, with significant inter-episodes variability.
“Although the mean delays (around 1.5 s) we found were somewhat shorter than the ones found in the above study (about 1.9–2 s)29, we found significant inter-episodes variability, which might explain this discrepancy, apart from the notable experimental set-up differences (species, head-fixed vs. head-free) and arousal state (sleep vs. wakefulness).”
From Local hippocampal fast gamma rhythms precede brain-wide hyperemic patterns during spontaneous rodent REM sleep (2018) · cites this paper as [29]
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Sasaki, D., Imai, K., Ikoma, Y., & Matsui, K. (2024) · eLife · doi:10.7554/elife.93721.3 · Cited by 6 · see citing works
- Authors
- Mateo, C., Knutsen, P. M., Tsai, P. S., Shih, A. Y., & Kleinfeld, D.
- Affiliations
- University of California San Diego (US)
- Medical University of South Carolina (US)
- Corresponding author
- Kleinfeld, David
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 96
- Issue
- 4
- Pages
- 936-948.e3
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5851777
- OpenAlex
- W2766937272
- Cited by
- 303
- References
- 87
- Citations by year
- 2026: 24 · 2025: 37 · 2024: 37 · 2023: 30 · 2022: 37 · 2021: 39 · 2020: 37 · 2019: 31 · 2018: 27 · 2017: 4
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- United States National Institute of Mental Health (MH108503, MH111438)
- United States National Institute of Neurological Disease and Stroke (NS082097, NS097265)
- United States National Institute of Biomedical Imaging and Bioengineering (EB003832)
- United States National Institute of General Medical Sciences (GM12345)
- United States National Science Foundation (PHY-153264, OIA-1539034)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- neural entrainment, resting-state functional connectivity, BOLD signal, blood oxygenation, gamma oscillations, optogenetic manipulation, cerebral cortex, functional connectivity
- MeSH terms
- Animals, Arterioles, Cerebral Cortex, Corpus Callosum, Magnetic Resonance Imaging, Male, Mice, Transgenic, Neural Pathways, Oxygen, Rest, Vasodilation, Mice, Neuroimaging, Gamma Rhythm
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