The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain
Abstract
The potential toxicity of nanoplastics on plants has previously been illustrated, but whether nanoplastics could cause neurotoxicity, especially to higher animals, remains unclear. We now demonstrate that nanoplastics can be deposited in the brain via nasal inhalation, triggering neuron toxicity and altering the animal behavior. Polystyrene nanoparticles (PS-NPs) of PS-COOH and PS-NH 2 are used as models for nanoplastics. We designed a microfluidic chip to evaluate the PS-NPs with different concentrations, surface ligands, and sizes to interact with neurons. Smaller PS-NPs can induce more cellular uptake than larger PS-NPs. PS-NPs with a size of 80 nm can reach and deposit in the brain of mice via aerosol inhalation. Mice inhaling PS-NPs exhibit fewer activities in comparison to those inhaling water droplets. An obvious neurotoxicity of the nanoplastics could be observed from the results of the inhibition of AChE activities. Our results show the potential significance of the physiochemical properties of organic nanoplastics on depositing in mammalian brains by nasal inhalation.
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Deng, Y., Zhang, Y., Lemos, B., & Ren, H. (2017) · Scientific Reports · doi:10.1038/srep46687 · Cited by 1,471
Mattsson, K., Johnson, E. V., Malmendal, A., Linse, S., Hansson, L.-A., & Cedervall, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-10813-0 · Cited by 823
Ding, J., Zhang, S., Razanajatovo, R. M., Zou, H., & Zhu, W. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.03.001 · Cited by 766
The United States’ contribution of plastic waste to land and ocean
Law, K. L., Starr, N., Siegler, T. R., Jambeck, J. R., Mallos, N. J., & Leonard, G. H. (2020) · Science Advances · doi:10.1126/sciadv.abd0288 · Cited by 525
Delivery of oxytocin to the brain for the treatment of autism spectrum disorder by nasal application
Tanaka, A., Furubayashi, T., Arai, M., Inoue, D., Kimura, S., Kiriyama, A., Kusamori, K., Katsumi, H., Yutani, R., Sakane, T., et al. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00991 · Cited by 104
Cited by
Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells
Lin, S., Zhang, H., Wang, C., Su, X.-L., Song, Y., Wu, P., Yang, Z., Wong, M.-H., Cai, Z., & Zheng, C. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c03980 · Cited by 391
Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
Liu, Z., Sokratian, A., Duda, A. M., Xu, E., Stanhope, C., Fu, A., Strader, S., Li, H., Yuan, Y., Bobay, B. G., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi8716 · Cited by 262
Metadata
- Authors
- Liu, X., Zhao, Y., Dou, J., Hou, Q., Cheng, J., & Jiang, X.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-01-28
- Volume
- 22
- Issue
- 3
- Pages
- 1091-1099
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W4210528961
- Cited by
- 175
- References
- 5
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, X., Zhao, Y., Dou, J., Hou, Q., Cheng, J., & Jiang, X. (2022). Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain. Nano Letters. https://doi.org/10.1021/acs.nanolett.1c04184
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