Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis niloticus)
Abstract
While the presence of microplastics (MPs) in marine environments has been detected worldwide, the importance of MPs pollution in freshwater environments has also been emphasized in recent years. However, the body of knowledge regarding the biological effects of MPs on freshwater organisms is still much more limited than on marine organisms. The aim of the present study was to evaluate the accumulation and tissue distribution of MPs in the freshwater fish red tilapia (Oreochromis niloticus), as well as the biochemical effects of MPs on O. niloticus. During 14 days of exposure to 0.1 μm polystyrene-MPs at concentrations of 1, 10, and 100 μg L-1, the MPs concentrations in various tissues of O. niloticus generally increased over time following the order gut > gills > liver ≈ brain. Moreover, the acetylcholinesterase (AChE) activity in the fish brain was inhibited by MPs exposure, with a maximum inhibition rate of 37.7%, suggesting the potential neurotoxicity of MPs to freshwater fish. The activities of cytochrome P450 (CYP) enzymes [7-ethoxyresorufin O-deethylase (EROD) and 7-benzyloxy-4-trifluoromethyl-coumarin O-dibenzyloxylase (BFCOD)] in the fish liver exhibited clear temporal variabilities, with significant decreases followed by elevations compared to the control. The alterations of the EROD and BFCOD activities indicate the potential involvement of CYP enzymes for the metabolism of MPs. The activity of antioxidative enzyme superoxide dismutase (SOD) in the liver was significantly induced throughout the exposure period, while the malondialdehyde (MDA) content did not vary with MPs exposure, suggesting that the antioxidative enzymatic system in O. niloticus could prevent oxidative damage. These results highlight the ingestion and accumulation of MPs in different tissues of freshwater fish, which lead to perturbations in fish biological systems and should be considered in environmental risk assessment.
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Micro- and nanoplastics (MNPs) are small enough to enter the body's cells, tissues, and major organs and interfere with physiological molecular and biological processes.
“These particles, collectively called micro- and nanoplastics (MNPs), are small enough to enter the body’s cells, tissues, and major organs and then interfere with physiological molecular and biological processes, such as protein structure [4] and cell membranes [5].”
From Consumption of Bottled Water and Chronic Diseases: A Nationwide Cross-Sectional Study (2024) · cites this paper as [4]
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Consumption of Bottled Water and Chronic Diseases: A Nationwide Cross-Sectional Study
Dolcini, J., Chiavarini, M., Firmani, G., Ponzio, E., D’Errico, M. M., & Barbadoro, P. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081074 · Cited by 15 · see citing works
“These particles, collectively called micro-and nanoplastics (MNPs), are small enough to enter the body’s cells, tissues, and major organs and then interfere with physiological molecular and biological processes, such as protein structure [4] and cell membranes [5].”
Background
- Authors
- Ding, J., Zhang, S., Razanajatovo, R. M., Zou, H., & Zhu, W.
- Affiliations
- Jiangnan University (CN)
- Freshwater Fisheries Research Center (CN)
- Corresponding author
- Zou, Hua
- Zhu, Wenbin
- Venue
- Environmental Pollution
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 238
- Pages
- 1-9
- ISSN
- 0269-7491 (ISSN-L)
- OpenAlex
- W2793554595
- Cited by
- 766
- References
- 59
- Citations by year
- 2026: 61 · 2025: 124 · 2024: 121 · 2023: 127 · 2022: 116 · 2021: 103 · 2020: 69 · 2019: 36 · 2018: 9
- FWCI
- 20.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Environmental Pollution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province, China (BK20170188)
- National Key Research and Development Program of China (2016YFE0123600)
- Fundamental Research Funds for the Central Universities (JUSRP11714)
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- polystyrene microplastics, microplastic accumulation, tissue distribution, red tilapia, Oreochromis niloticus, freshwater fish, acetylcholinesterase inhibition, neurotoxicity, cytochrome P450, ethoxyresorufin-O-deethylase, superoxide dismutase, oxidative stress, malondialdehyde, environmental risk assessment
- MeSH terms
- Acetylcholinesterase, Animals, Antioxidants, Brain, Cholinesterase Inhibitors, Fresh Water, Gills, Liver, Malondialdehyde, Polystyrenes, Superoxide Dismutase, Tissue Distribution, Water Pollutants, Chemical, Tilapia, Cytochrome P-450 CYP1A1, Gastrointestinal Tract
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