Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain
Open accessAbstract
The tremendous increases in production of plastic materials has led to an accumulation of plastic pollution worldwide. Many studies have addressed the physical effects of large-sized plastics on organisms, whereas few have focused on plastic nanoparticles, despite their distinct chemical, physical and mechanical properties. Hence our understanding of their effects on ecosystem function, behaviour and metabolism of organisms remains elusive. Here we demonstrate that plastic nanoparticles reduce survival of aquatic zooplankton and penetrate the blood-to-brain barrier in fish and cause behavioural disorders. Hence, for the first time, we uncover direct interactions between plastic nanoparticles and brain tissue, which is the likely mechanism behind the observed behavioural disorders in the top consumer. In a broader perspective, our findings demonstrate that plastic nanoparticles are transferred up through a food chain, enter the brain of the top consumer and affect its behaviour, thereby severely disrupting the function of natural ecosystems.
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Nanoplastics likely have adverse effects on aquatic organisms.
“They likely have adverse effects on aquatic organisms (Mattsson et al., 2017;Jeong et al., 2018;Baudrimont et al., 2020;Wayman and Niemann, 2021)”
From Plastic photodegradation under simulated marine conditions (2023) · cites this paper as Mattsson et al., 2017
Daphnia magna exposed to nanoplastics showed increased toxicity, physical damage and higher mortality rates as a function of nanoplastic exposure.
“The results of the studies have shown an increased toxicity, physical damage and higher mortality rates of Daphnia as a function of nanoplastic exposure.”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
Experimental studies suggest that the effects of nanoplastics are more negative compared to macro/micro plastic counterparts, at least under tested exposure conditions, which might be higher than environmental levels.
“Nanoplastics might simply pass through organisms without further interactions but experimental studies rather suggest that the effects of nanoplastics are more negative when compared to their macro/micro plastic counterparts, at least under the tested exposure conditions, 16,147 which might be higher than environmental levels.”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
At least for fish, nanoplastics can cross the blood brain barrier, accumulate in several vital organs, and disrupt metabolism and hormonal signalling.
“Noteworthy is that at least for sh, nanoplastics can cross the blood brain barrier, 16 accumulate in several vital organs, 158,159 and disrupt metabolism and hormonal signalling.158”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
The fitness of Daphnia magna was impaired by small nanoplastic particles of ~52 nm but not by larger ones of >120 nm, and depuration of 24 nm particles was faster than that of 250 nm particles.
“The tness of Daphnia magna was impaired by small nanoplastic particles of $52 nm but not by larger ones of >120 nm, 16 and the depuration of 24 nm particles was faster than that of 250 nm particles.156”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
Nanoplastics have high surface to volume ratios and thus better adsorb toxic compounds and potentially transfer them to organisms after ingestion.
“Nanoplastics are characterised by high surface to volume ratios and thus better adsorb toxic compounds and potentially transfers them to organisms aer ingestion.16,18,137,[147][148][149]”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
The chemical composition of nanomaterials defines their behaviour in biological systems, perhaps due to differences in physicochemical surface properties.
“This could suggest that the chemical composition of the nanomaterials denes their behaviour in biological systems, perhaps due to differences in physicochemical surface properties.16,156”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
Transfer of nanoplastic through food web structures was shown for an algae-crustacean-fish system, providing evidence for potential negative effects on all trophic levels.
“The transfer of nanoplastic through food web structures could be shown for an algae-crustacean-sh system 16,155 providing evidence for potential negative effects of nanoplastic exposure on all trophic levels.”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
Negative effects of nanoplastics might be dependent on size and polymer type.
“Furthermore, negative effects of nanoplastics might be dependent on size, and polymer type.16”
From The fate of plastic in the ocean environment – a minireview (2021) · cites this paper as [16]
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- Authors
- Mattsson, K., Johnson, E. V., Malmendal, A., Linse, S., Hansson, L.-A., & Cedervall, T.
- Affiliations
- Lund University (SE)
- Corresponding author
- Mattsson, Karin
- Venue
- Scientific Reports
- Published
- 2017-09-13
- Volume
- 7
- Issue
- 1
- Pages
- 11452-11452
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5597631
- OpenAlex
- W2752608807
- Cited by
- 823
- References
- 34
- Citations by year
- 2026: 71 · 2025: 98 · 2024: 128 · 2023: 141 · 2022: 113 · 2021: 103 · 2020: 82 · 2019: 58 · 2018: 26 · 2017: 3
- FWCI
- 20.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Lunds Universitet
- Vetenskapsrådet
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- nanoplastics, microplastics, fish behavior, brain damage, blood-brain barrier, zooplankton survival, trophic transfer, neurotoxicity, plastic pollution, aquatic ecosystems
- MeSH terms
- Animals, Brain Injuries, Environmental Pollution, Fish Diseases, Mortality, Plastics, Water Pollutants, Chemical, Food Chain, Nanoparticles
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