Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

Deng, Yongfeng; Zhang, Yan; Lemos, Bernardo; Ren, Hongqiang

doi:10.1038/srep46687

Cited by 1,471Microplastics and Plastic PollutionEnvironmental Toxicology and EcotoxicologyPharmaceutical and Antibiotic Environmental Impacts

Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

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Deng, Yongfeng, Zhang, Yan, Lemos, Bernardo, Ren, Hongqiang·2017·Scientific Reports

DOI 10.1038/srep46687PMC PMC5402289

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Abstract

Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs.

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In vivo studies in mammals have shown effects at high exposure concentrations, including changes in energy and lipid metabolism and oxidative stress.
“In vivo studies examining the impacts of microplastics in mammals have also shown effects at high exposure concentrations, including changes in energy and lipid metabolism and oxidative stress (polystyrene particles 5μm in diameter at a concentration of 1.46×106 particles/0.5mL and 20μm in diameter at a concentration of 2.27×104 particles/0.5mL)30”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
The Discussion and Results report changes in energy and lipid metabolism and oxidative-stress biomarkers in mice exposed to polystyrene microplastics. However, Methods > Tissue accumulation of MPs in mice gives the quoted particle counts for the fluorescent-particle accumulation experiment; Methods > Toxicological experiment gives different particle counts for the experiment that measured those effects. The sentence therefore supports the effects but attaches them to the wrong exact exposure counts. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Some in vitro and in vivo studies examining impacts of microplastics on mammals show effects, such as intestinal barrier disfunction and alteration of biomarkers.
“Although some in vitro and in vivo studies examining impacts of microplastics on mammals show effects, such as intestinal barrier disfunction and alteration of biomarkers,30,31”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
The Abstract reports that microplastic exposure in mice altered several biochemical and blood biomarkers, supporting the biomarker part of the claim. The paper does not report intestinal barrier dysfunction; its Discussion addresses gut accumulation and possible effects on food absorption, which are not the same finding. No page numbers are available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
It is unclear if toxicological effects from physical or chemical mechanisms of microplastics are occurring in humans, and at what thresholds effects occur.
“However, it is unclear if toxicological effects from either of these mechanisms are occurring in humans, and at what thresholds effects occur.”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [30]
The Discussion (page not provided) says no quantitative data on microplastics in human tissues had been reported and describes adverse-effects research in mammals as limited, supporting uncertainty about effects in humans. It does not address whether physical versus chemical mechanisms cause human toxicity or identify thresholds at which human effects occur; the reported doses and biomarker responses are from mice. (LLM, conf=0.81)
Experimental — accuracy not yet measured

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Authors: Deng, Y., Zhang, Y., Lemos, B., & Ren, H.
Affiliations: State Key Laboratory of Pollution Control and Resource Reuse (CN)
Harvard University (US)
Corresponding author: Zhang, Yan
ORCID: Deng, Yongfeng
Zhang, Yan
Lemos, Bernardo
Ren, Hongqiang
Venue: Scientific Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-04-24
Volume: 7
Issue: 1
Pages: 46687-46687
ISSN: 2045-2322 (ISSN-L)
DOI: 10.1038/srep46687
PMC: PMC5402289
OpenAlex: W2608368045
Cited by: 1,471
References: 50
Citations by year: 2026: 160 · 2025: 243 · 2024: 267 · 2023: 220 · 2022: 244 · 2021: 160 · 2020: 101 · 2019: 50 · 2018: 22 · 2017: 3
FWCI: 21.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Scientific Reports (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (21407076, 21304045, 21507058)
Topics: Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords: microplastics, polystyrene microplastics, tissue accumulation, particle size effects, liver, kidney, intestine, energy metabolism, lipid metabolism, oxidative stress, neurotoxicity biomarkers, metabolomics, biomarkers, mouse model, health risks
MeSH terms: Animals, Environmental Exposure, Kidney, Liver, Male, Mice, Inbred ICR, Particle Size, Polystyrenes, Risk Factors, Tissue Distribution, Water Pollutants, Chemical, Biomarkers, Gastrointestinal Tract, Metabolomics

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Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

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