Magnetic drug targeting: preclinical in vivo studies, mathematical modeling, and extrapolation to humans
Open accessAbstract
A sound theoretical rationale for the design of a magnetic nanocarrier capable of magnetic capture in vivo after intravenous administration could help elucidate the parameters necessary for in vivo magnetic tumor targeting. In this work, we utilized our long-circulating polymeric magnetic nanocarriers, encapsulating increasing amounts of superparamagnetic iron oxide nanoparticles (SPIONs) in a biocompatible oil carrier, to study the effects of SPION loading and of applied magnetic field strength on magnetic tumor targeting in CT26 tumor-bearing mice. Under controlled conditions, the in vivo magnetic targeting was quantified and found to be directly proportional to SPION loading and magnetic field strength. Highest SPION loading, however, resulted in a reduced blood circulation time and a plateauing of the magnetic targeting. Mathematical modeling was undertaken to compute the in vivo magnetic, viscoelastic, convective, and diffusive forces acting on the nanocapsules (NCs) in accordance with the Nacev-Shapiro construct, and this was then used to extrapolate to the expected behavior in humans. The model predicted that in the latter case, the NCs and magnetic forces applied here would have been sufficient to achieve successful targeting in humans. Lastly, an in vivo murine tumor growth delay study was performed using docetaxel (DTX)-encapsulated NCs. Magnetic targeting was found to offer enhanced therapeutic efficacy and improve mice survival compared to passive targeting at drug doses of ca. 5-8 mg of DTX/kg. This is, to our knowledge, the first study that truly bridges the gap between preclinical experiments and clinical translation in the field of magnetic drug targeting.
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Al-Jamal et al. concluded that their magnetic drug targeting approach would be feasible in humans if particles of the right size and SPION content can be employed.
“They concluded that their magnetic drug targeting approach would be feasible in human, if particles of the right size and the right SPION content can be employed.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [225]
Magnetic targeting in CT26 tumor-bearing mice was directly proportional to SPION loading and magnetic field strength.
“The in vivo results showed that magnetic targeting in CT26 tumor bearing mice was directly proportional to SPION loading and magnetic field strength.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [225]
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- Authors
- Al-Jamal, K. T., Bai, J., Wang, J. T.-W., Protti, A., Southern, P., Bogart, L., Heidari, H., Li, X., Cakebread, A., Asker, D., Al-Jamal, W. T., Shah, A., Bals, S., Sosabowski, J., & Pankhurst, Q. A.
- Affiliations
- King’s College London , , ,
- Queen Mary University of London (GB)
- University of Antwerp (BE)
- University of East Anglia (GB)
- Corresponding author
- Pankhurst, Quentin A.
- ORCID
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-08-19
- Volume
- 16
- Issue
- 9
- Pages
- 5652-5660
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2509450930
- Cited by
- 179
- References
- 24
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 15 · 2023: 17 · 2022: 16 · 2021: 24 · 2020: 36 · 2019: 25 · 2018: 17 · 2017: 6 · 2016: 1
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nano Letters (publishedVersion, other-oa)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/J008656/1)
- Kings College London (NA)
- China Scholarship Council (NA)
- Worldwide Cancer Research (12-1054)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- magnetic drug delivery, superparamagnetic iron oxide nanoparticles, CT26 cells, magnetic field strength, blood circulation time, docetaxel, tumor growth inhibition, clinical translation
- MeSH terms
- Animals, Humans, Magnetic Resonance Imaging, Magnetics, Mice, Inbred BALB C, Models, Theoretical, Neoplasms, Drug Delivery Systems, Cell Line, Tumor, Mice, Nanocapsules, Magnetite Nanoparticles
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