The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Novel Asymmetric Wettable AgNPs/Chitosan Wound Dressing: In Vitro and In Vivo Evaluation
Abstract
A novel silver nanoparticles (AgNPs)/chitosan composite dressing with asymmetric wettability surfaces was successfully prepared via a simple two-step method for biomedical applications as wound healing materials. First, AgNPs were assembled into the chitosan sponge which was prepared by lyophilization process. Then one side of the sponge was modified by a thin layer of stearic acid. The incorporation of AgNPs into chitosan dressing could enhance the antibacterial activity against drug-sensitive and drug-resistant pathogenic bacteria. The asymmetric surface modification endows the dressing with both highly hydrophobic property and inherent hydrophilic nature of chitosan. The hydrophobic surface of the dressing shows waterproof and antiadhesion for contaminant properties, whereas the hydrophilic surface preserves its water-absorbing capability and efficiently inhibits the growth of bacteria. Furthermore, the AgNPs/chitosan composite dressing displays improved moisture retention and blood clotting ability compared to the unmodified dressings. Cytocompatibility test evaluated in vitro and in a wound infection model illustrates the nontoxic nature of the composite dressing. More importantly, the in vivo wound healing model evaluation in mice reveals that the asymmetric AgNPs/chitosan dressing promotes the wound healing and accelerates the reepithelialization and collagen deposition. The silver accumulation in mice body treated by the composite dressing is far lower than that of the clinically used Acasin nanosilver dressing treated mice. This work indicates the huge potential of the novel AgNPs/chitosan wound dressing with asymmetrical wettability for clinical use.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Sudheesh Kumar, P. T., Lakshmanan, V.-K., Anilkumar, T. V., Ramya, C., Reshmi, P., Unnikrishnan, A. G., Nair, S. V., & Jayakumar, R. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am300292v · Cited by 752
RetractedA review of chitin and chitosan applications
Ravi Kumar, M. N. V. (2000) · Reactive and Functional Polymers · doi:10.1016/s1381-5148(00)00038-9 · Cited by 6,009
Hansen, M. B., Nielsen, S. E., & Berg, K. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90397-9 · Cited by 3,507
Chitosan—A versatile semi-synthetic polymer in biomedical applications
Dash, M., Chiellini, F., Ottenbrite, R. M., & Chiellini, E. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.02.001 · Cited by 2,903
Biomaterials based on chitin and chitosan in wound dressing applications
Jayakumar, R., Prabaharan, M., Sudheesh Kumar, P. T., Nair, S. V., & Tamura, H. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.01.005 · Cited by 1,924
Preparation and Characterization of Chitosan-Based Nanocomposite Films with Antimicrobial Activity
Rhim, J.-W., Hong, S.-I., Park, H.-M., & Ng, P. K. W. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060658h · Cited by 960
Moisturization and skin barrier function
Rawlings, A. V., & Harding, C. R. (2004) · Dermatologic Therapy · doi:10.1111/j.1396-0296.2004.04s1005.x · Cited by 924
Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties
Ong, S.-Y., Wu, J., Moochhala, S. M., Tan, M.-H., & Lu, J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.034 · Cited by 830
Effect of Air Exposure and Occlusion on Experimental Human Skin Wounds
HINMAN, C. D., & MAIBACH, H. (1963) · Nature · doi:10.1038/200377a0 · Cited by 711
Cutaneous tissue repair: Basic biologic considerations. I
Clark, R. A. F. (1985) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(85)70213-7 · Cited by 588
Electrospun collagen/chitosan nanofibrous membrane as wound dressing
Chen, J.-P., Chang, G.-Y., & Chen, J.-K. (2008) · Colloids and Surfaces A: Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2007.04.129 · Cited by 515
A review on ‘self-cleaning and multifunctional materials’
Ragesh, P., Anand Ganesh, V., Nair, S. V., & Nair, A. S. (2014) · J. Mater. Chem. A · doi:10.1039/c4ta02542c · Cited by 481
Lu, Z., Rong, K., Li, J., Yang, H., & Chen, R. (2013) · Journal of Materials Science: Materials in Medicine · doi:10.1007/s10856-013-4894-5 · Cited by 418
Self-citationA bioinspired fouling-resistant surface modification for water purification membranes
McCloskey, B. D., Park, H. B., Ju, H., Rowe, B. W., Miller, D. J., & Freeman, B. D. (2012) · Journal of Membrane Science · doi:10.1016/j.memsci.2012.04.021 · Cited by 345
Hydrogel sheets of chitosan, honey and gelatin as burn wound dressings
Wang, T., Zhu, X.-K., Xue, X.-T., & Wu, D.-Y. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.11.069 · Cited by 326
Kumar, P. T. S., Abhilash, S., Manzoor, K., Nair, S. V., Tamura, H., & Jayakumar, R. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.12.024 · Cited by 312
Bioengineering skin using mechanisms of regeneration and repair
Metcalfe, A. D., & Ferguson, M. W. J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.031 · Cited by 232
Chitosan: A Biocompatible Material for Oral and Intravenous Administrations
Hirano, S., Seino, H., Akiyama, Y., & Nonaka, I. (1990) · Progress in Biomedical Polymers · doi:10.1007/978-1-4899-0768-4_28 · Cited by 219
Experience with Chitosan Dressings in a Civilian EMS System
Brown, M. A., Daya, M. R., & Worley, J. A. (2009) · The Journal of Emergency Medicine · doi:10.1016/j.jemermed.2007.05.043 · Cited by 191
Miao, J., Pangule, R. C., Paskaleva, E. E., Hwang, E. E., Kane, R. S., Linhardt, R. J., & Dordick, J. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.080 · Cited by 184
Han, F., Dong, Y., Su, Z., Yin, R., Song, A., & Li, S. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.09.036 · Cited by 180
Cotton Fabrics with Single-Faced Superhydrophobicity
Liu, Y., Xin, J. H., & Choi, C.-H. (2012) · Langmuir · doi:10.1021/la303714h · Cited by 168
Regiel-Futyra, A., Irusta, S., Kyzioł, A., Arruebo, M., & Santamarı́a, J. (2012) · Nanotechnology · doi:10.1088/0957-4484/24/1/015101 · Cited by 144
Asymmetric Free-Standing Film with Multifunctional Anti-Bacterial and Self-Cleaning Properties
Shen, L., Wang, B., Wang, J., Fu, J., Picart, C., & Ji, J. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am301118f · Cited by 136
In vitro properties of a chitosan-bonded hydroxyapatite bone-filling paste
Ito, M. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90130-3 · Cited by 131
Bendtsen, S. T., & Wei, M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00072f · Cited by 114
Chitosan composites for biomedical applications: Status, challenges and perspectives
Hein, S., Wang, K., Stevens, W. F., & Kjems, J. (2008) · Materials Science and Technology · doi:10.1179/174328408x341744 · Cited by 108
Superhydrophobic chitosan-based coatings for textile processing
Иванова, Н. А., & Philipchenko, A. B. (2012) · Applied Surface Science · doi:10.1016/j.apsusc.2012.09.173 · Cited by 101
Zakhem, E., Raghavan, S. A., Gilmont, R. R., & Bitar, K. N. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.051 · Cited by 101
Wang, L., Xi, G., Wan, S. J., Zhao, C., & Liu, X. (2014) · Cellulose · doi:10.1007/s10570-014-0275-6 · Cited by 77
Rydell‐Törmänen, K., Andréasson, K., Hesselstrand, R., Risteli, J., Heinegård, D. K., Saxne, T., & Westergren‐Thorsson, G. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.57 · Cited by 59
Gezer, P. G., Brodsky, S., Hsiao, A., Liu, G. L., & Kokini, J. L. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.006 · Cited by 57
Antifouling Self-Cleaning Surfaces
Yin, X., & Yu, B. (2014) · Springer eBooks · doi:10.1007/978-3-662-45204-2_1 · Cited by 7
Cited by
Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review
Mulani, M. S., Kamble, E. E., Kumkar, S. N., Tawre, M. S., & Pardesi, K. R. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00539 · Cited by 1,644
A Self‐Pumping Dressing for Draining Excessive Biofluid around Wounds
Shi, L., Liu, X., Wang, W., Jiang, L., & Wang, S. (2019) · Advanced Materials · doi:10.1002/adma.201804187 · Cited by 406
Recent advances in chitin based materials constructed via physical methods
Duan, B., Huang, Y., Lu, A., & Zhang, L. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.04.001 · Cited by 386
Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites
Naseri-Nosar, M., & Ziora, Z. M. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.02.003 · Cited by 325
Li, M., Chen, J., Shi, M., Zhang, H., Ma, P. X., & Guo, B. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.121999 · Cited by 322
Metadata
- Authors
- Liang, D., Lu, Z., Yang, H., Gao, J., & Chen, R.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-02-03
- Volume
- 8
- Issue
- 6
- Pages
- 3958-3968
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2254012488
- Cited by
- 403
- References
- 33
- FWCI
- 44.38
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
