The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations
Abstract
Immediate hemorrhage control and infection prevention are pivotal for saving lives in critical situations such as battlefields, natural disasters, traffic accidents, and so on. In situ hydrogels are promising candidates, but their mechanical strength is often not strong enough for use in critical situations. In this study, we constructed three hydrogels with different amounts of Schiff-base moieties from 4-arm-PEG-NH2, 4-arm-PEG-NHS, and 4-arm-PEG-CHO in which vancomycin was incorporated as an antimicrobial agent. The hydrogels possess porous structures, excellent mechanical strength, and high swelling ratio. The cytotoxicity studies indicated that the composite hydrogel systems possess good biocompatibility. The Schiff bases incorporated improve the adhesiveness and endow the hydrogels with bacteria-sensitivity. The in vivo hemostatic and antimicrobial experiments on rabbits and pigs demonstrated that the hydrogels are able to aid in rapid hemorrhage control and infection prevention. In summary, vancomycin-loaded hydrogels may be excellent candidates as hemostatic and antibacterial materials for first aid treatment of the wounded in critical situations.
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Sakai, T., Matsunaga, T., Yamamoto, Y., Ito, C., Yoshida, R., Suzuki, S., Sasaki, N., Shibayama, M., & Chung, U.-I. (2008) · Macromolecules · doi:10.1021/ma800476x · Cited by 1,274
Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
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Recent advances in wet adhesives: Adhesion mechanism, design principle and applications
Cui, C., & Liu, W. (2021) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2021.101388 · Cited by 557
Cui, C., Fan, C., Wu, Y., Xiao, M., Wu, T., Zhang, D., Chen, X., Liu, B., Xu, Z., Qu, B., et al. (2019) · Advanced Materials · doi:10.1002/adma.201905761 · Cited by 542
Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing
Pourshahrestani, S., Zeimaran, E., Kadri, N. A., Mutlu, N., & Boccaccini, A. R. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000905 · Cited by 448
Zhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00071 · Cited by 394
Metadata
- Authors
- Bu, Y., Zhang, L., Liu, J., Zhang, L., Li, T., Shen, H., Wang, X., Yang, F., Tang, P., & Wu, D.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-05-16
- Volume
- 8
- Issue
- 20
- Pages
- 12674-12683
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2346039567
- Cited by
- 204
- References
- 2
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bu, Y., Zhang, L., Liu, J., Zhang, L., Li, T., Shen, H., Wang, X., Yang, F., Tang, P., & Wu, D. (2016). Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.6b03235
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