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Cited by 285

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Techniques for Accurate Sizing of Gold Nanoparticles Using Dynamic Light Scattering with Particular Application to Chemical and Biological Sensing Based on Aggregate Formation

Open access
Zheng, Tianyu, Bott, Steven, Huo, Qun·2016·ACS Applied Materials & Interfaces
DOI 10.1021/acsami.6b06903
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Abstract

Gold nanoparticles (AuNPs) have found broad applications in chemical and biological sensing, catalysis, biomolecular imaging, in vitro diagnostics, cancer therapy, and many other areas. Dynamic light scattering (DLS) is an analytical tool used routinely for nanoparticle size measurement and analysis. Due to its relatively low cost and ease of operation in comparison to other more sophisticated techniques, DLS is the primary choice of instrumentation for analyzing the size and size distribution of nanoparticle suspensions. However, many DLS users are unfamiliar with the principles behind the DLS measurement and are unware of some of the intrinsic limitations as well as the unique capabilities of this technique. The lack of sufficient understanding of DLS often leads to inappropriate experimental design and misinterpretation of the data. In this study, we performed DLS analyses on a series of citrate-stabilized AuNPs with diameters ranging from 10 to 100 nm. Our study shows that the measured hydrodynamic diameters of the AuNPs can vary significantly with concentration and incident laser power. The scattered light intensity of the AuNPs has a nearly sixth order power law increase with diameter, and the enormous scattered light intensity of AuNPs with diameters around or exceeding 80 nm causes a substantial multiple scattering effect in conventional DLS instruments. The effect leads to significant errors in the reported average hydrodynamic diameter of the AuNPs when the measurements are analyzed in the conventional way, without accounting for the multiple scattering. We present here some useful methods to obtain the accurate hydrodynamic size of the AuNPs using DLS. We also demonstrate and explain an extremely powerful aspect of DLS-its exceptional sensitivity in detecting gold nanoparticle aggregate formation, and the use of this unique capability for chemical and biological sensing applications.

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Metadata

Authors
Zheng, T., Bott, S., & Huo, Q.
Venue
ACS Applied Materials & Interfaces
Publisher
American Chemical Society (ACS)
Published
2016-08-09
Volume
8
Issue
33
Pages
21585-21594
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
DOI
10.1021/acsami.6b06903
OpenAlex
W2476529906
Cited by
285
References
35
FWCI
7.91
Type
journal article
Language
en
Open access
green

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