The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Porous Iron-Carboxylate Metal–Organic Framework: A Novel Bioplatform with Sustained Antibacterial Efficacy and Nontoxicity
Abstract
Sustained drug release plays a critical role in targeting the therapy of local diseases such as bacterial infections. In the present work, porous iron-carboxylate metal-organic framework [MOF-53(Fe)] nanoparticles (NPs) were designed to entrap the vancomycin (Van) drugs. This system exhibited excellent chemical stability under acidic conditions (pH 7.4, 6.5, and 5.5) and much higher drug-loading capability because of the high porosity and large surface area of MOF NPs. The results showed that the drug-loading ratio of Van could reach 20 wt % and that the antibacterial ratio of the MOF-53(Fe)/Van system against Staphylococcus aureus could reach up to 90%. In addition, this MOF-53(Fe)/Van system exhibited excellent biocompatibility because of its chemical stability and sustained release of iron ions. Hence, these porous MOF NPs are a promising bioplatform not only for local therapy of bacterial infections but also for other biomedical therapies for tissue regeneration.
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Horike, S., Shimomura, S., & Kitagawa, S. (2009) · Nature Chemistry · doi:10.1038/nchem.444 · Cited by 2,486
BioMOFs: Metal–Organic Frameworks for Biological and Medical Applications
McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000048 · Cited by 1,256
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Gao, X., Song, J., Ji, P., Zhang, X., Li, X., Xu, X., Wang, M., Zhang, S., Deng, Y., Deng, F., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b12413 · Cited by 170
Dopamine Modified Organic–Inorganic Hybrid Coating for Antimicrobial and Osteogenesis
Li, M., Liu, X., Xu, Z., Yeung, K. W. K., & Wu, S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b09457 · Cited by 154
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Cited by
Metal–Organic-Framework-Based Materials for Antimicrobial Applications
Li, R., Chen, T., & Pan, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09617 · Cited by 555
Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Metadata
- Authors
- Lin, S., Liu, X., Tan, L., Cui, Z., Yang, X., Yeung, K. W. K., Pan, H., & Wu, S.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-05-30
- Volume
- 9
- Issue
- 22
- Pages
- 19248-19257
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2620386211
- Cited by
- 172
- References
- 5
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
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