Cited by 170Bone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical Applicationsbiodegradable polymer synthesis and properties

Polydopamine-Templated Hydroxyapatite Reinforced Polycaprolactone Composite Nanofibers with Enhanced Cytocompatibility and Osteogenesis for Bone Tissue Engineering

Gao, Xiang, Song, Jinlin, Ji, Ping, Zhang, Xiaohong, Li, Xiaoman, Xu, Xiao, Wang, Mengke, Zhang, Siqi +3 more·2016·ACS Applied Materials & Interfaces

Abstract

Nanohydroxyapatite (HA) synthesized by biomimetic strategy is a promising nanomaterial as bone substitute due to its physicochemical features similar to those of natural nanocrystal in bone tissue. Inspired by mussel adhesive chemistry, a novel nano-HA was synthesized in our work by employing polydopamine (pDA) as template under weak alkaline condition. Subsequently, the as-prepared pDA-templated HA (tHA) was introduced into polycaprolactone (PCL) matrix via coelectrospinning, and a bioactive tHA/PCL composite nanofiber scaffold was developed targeted at bone regeneration application. Our research showed that tHA reinforced PCL composite nanofibers exhibited favorable cytocompatibility at given concentration of tHA (0-10 w.t%). Compared to pure PCL and traditional nano-HA enriched PCL (HA/PCL) composite nanofibers, enhanced cell adhesion, spreading and proliferation of human mesenchymal stem cells (hMSCs) were observed on tHA/PCL composite nanofibers on account of the contribution of pDA present in tHA. More importantly, tHA nanoparticles exposed on the surface of composite nanofibers could further promote osteogenesis of hMSCs in vitro even in the absence of osteogenesis soluble inducing factors when compared to traditional HA/PCL scaffolds, which was supported by in vivo test as well according to the histological analysis. Overall, our study demonstrated that the developed tHA/PCL composite nanofibers with enhanced cytocompatibility and osteogenic capacity hold great potent…

Integrity signals

Registry

Crossref · 10.1021/acsami.5b12413

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • PDA coating on Ti offers strong corrosive resistance.

    “which can offer the biosubstitute a strong corrosive resistance, an improved mechanical properties, and a high superficial energy [87].”
  • PDA coating on Ti offers improved mechanical properties.

    “which can offer the biosubstitute a strong corrosive resistance, an improved mechanical properties, and a high superficial energy [87].”
  • PDA coating on Ti offers high superficial energy.

    “which can offer the biosubstitute a strong corrosive resistance, an improved mechanical properties, and a high superficial energy [87].”
  • Once Ti is coated by a PDA layer, a special strong charge transfer interaction is formed between the PDA coating layer and Ti.

    “Once it is coated by the PDA layer, a special strong charge transfer interaction would be formed between the formed PDA coating layer and Ti”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gao, X., Song, J., Ji, P., Zhang, X., Li, X., Xu, X., Wang, M., Zhang, S., Deng, Y., Deng, F., & Wei, S.
Affiliations
  • Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China
  • Peking University (CN)
  • Chongqing Medical University (CN)
Corresponding author
  • Deng, Feng
  • Wei, Shicheng
Venue
ACS Applied Materials & Interfaces
Published
2016-01-26
Volume
8
Issue
5
Pages
3499-3515
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2235206546
Cited by
170
References
65
Citations by year
2026: 6 · 2025: 7 · 2024: 14 · 2023: 13 · 2022: 17 · 2021: 23 · 2020: 25 · 2019: 24 · 2018: 17 · 2017: 17 · 2016: 7
FWCI
10.43
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81271183, 81371697, 81570979)
  • Outstanding Doctoral Scientific Research Fund, Chongqing Medical University
  • Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education
  • Program for Innovation Team Building at Institutions of Higher Education in Chongqing
  • Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Medical University (ODBS-2014-001)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
hydroxyapatite nanoparticles, polycaprolactone, composite nanofibers, bone tissue engineering, bone formation, human mesenchymal stem cells, cytocompatibility, biomimetic synthesis, mussel-inspired materials, bone regeneration, scaffolds
MeSH terms
Biocompatible Materials, Bone Regeneration, Cell Adhesion, Cell Differentiation, Cells, Cultured, Humans, Indoles, Osteogenesis, Polyesters, Polymers, Durapatite, Tissue Engineering, Nanocomposites, Nanofibers, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review