Cited by 109Nanoparticle-Based Drug DeliveryDrug Transport and Resistance MechanismsNanoplatforms for cancer theranostics

Trackable Mitochondria-Targeting Nanomicellar Loaded with Doxorubicin for Overcoming Drug Resistance

Zhang, Ye, Zhang, Congjun, Chen, Jing, Liu, Li, Hu, Mengyue, Li, Jun, Bi, Hong·2017·ACS Applied Materials & Interfaces

Abstract

Multidrug resistance (MDR) has been recognized as a major obstacle to successful chemotherapy for cancer in the clinic. In recent years, more and more nanoscaled drug delivery systems (DDS) are constructed to modulate drug efflux protein (P-gp) and deliver chemotherapeutic drugs for overcoming MDR. Among them, d -α-tocopheryl polyethylene glycol succinate (TPGS) has been widely used as a drug carrier due to its capability of inhibiting overexpression of P-gp and good amphiphilicity favorable for improving permeation and long-circulation property of DDS. In the present work, a novel kind of mitochondria-targeting nanomicelles-based DDS is developed to integrate chemotherapeutics delivery with fluorescence imaging functionalities on a comprehensive nanoplatform. The mitochondria-targeting nanomicelles are prepared by self-assembly of triphenylphosphine (TPP)-modified TPGS and fluorescent carbon quantum dots (CQDs) in an n -hexane/H 2 O mixed solution, named CQDs-TPGS-TPP. Notably, although the drug loading content of doxorubicin (DOX) in the as-prepared nanomicelles is as low as 3.4%, the calculated resistant index (RI) is greatly decreased from 66.23 of free DOX to 7.16 of DOX-loaded nanomicelles while treating both parental MCF-7 cells and drug-resistant MCF-7/ADR cells. Compared with free DOX, the penetration efficiency of DOX-loaded nanomicelles in three-dimensional multicellular spheroids (MCs) of MCF-7/ADR is obviously increased. Moreover, the released DOX from the nanomicelles can cause much more damage to cells of drug-resistant MCs. These results demonstrate that our constructed mitochondria-targeting nanomicelles-based DDS have potential application in overcoming MDR of cancer cells as well as their MCs that mimic in vivo tumor tissues. The MDR-reversal mechanism of the DOX-loaded CQDs-TPGS-TPP nanomicelles is also discussed.

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Crossref · 10.1021/acsami.7b07219

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  • Nanomicelles have shown lower dissociation kinetics after dilution, around 1000-fold slower compared to conventional surfactant micelles.

    “As reported, the nanomicelles have shown lower dissociation kinetics after dilution around 1000-fold slower compared to conventional surfactant micelles.”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [11]

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Authors
Zhang, Y., Zhang, C., Chen, J., Liu, L., Hu, M., Li, J., & Bi, H.
Affiliations
  • Anhui University (CN)
  • Anhui Medical University (CN)
Corresponding author
Bi, Hong
Venue
ACS Applied Materials & Interfaces
Published
2017-07-24
Volume
9
Issue
30
Pages
25152-25163
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2734768350
Cited by
109
References
67
Citations by year
2026: 4 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 10 · 2021: 21 · 2020: 13 · 2019: 12 · 2018: 14 · 2017: 2
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Anhui University
  • National Natural Science Foundation of China (51272002)
  • Foundation for Imported Leading Talent Teams in Universities and Colleges of Anhui Province
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
doxorubicin, multidrug resistance, P-glycoprotein inhibition, TPGS, triphenylphosphine, carbon quantum dots, fluorescence imaging, drug delivery systems, MCF-7/ADR cells, tumor spheroids, drug penetration, drug resistance reversal
MeSH terms
Doxorubicin, Drug Carriers, Humans, Micelles, Mitochondria, Polyethylene Glycols, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Cell Line, Tumor, Nanostructures

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