Cited by 109Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryRadiation Therapy and Dosimetry

Theranostic Nanoplatform: Triple-Modal Imaging-Guided Synergistic Cancer Therapy Based on Liposome-Conjugated Mesoporous Silica Nanoparticles

Sun, Qi, You, Qing, Wang, Jinping, Liu, Li, Wang, Yidan, Song, Yilin, Cheng, Yu, Wang, Siyu +2 more·2018·ACS Applied Materials & Interfaces

Abstract

Mesoporous silica nanoparticles (MSNs) have long since been investigated to provide a versatile drug-delivery platform due to their multitudinous merits. Presently, gadolinium (Gd), a T1 magnetic resonance imaging (MRI) contrast agent, was doped into MSNs as a newly emerging theranostic nanocomposite, which has received much research attention. However, it is still concerned about the dispersibility and drug leakage of MSNs. Hence, in this project, we constructed an near-infrared (NIR) irradiation-triggered, triple-modal imaging-guided nanoplatform based on doxorubicin (DOX)@Gd-doped MSNs, conjugating with indocyanine green (ICG)-loaded thermosensitive liposomes (designated as DOX@GdMSNs-ICG-TSLs). In this platform, ICG could contribute to both photodynamic therapy and photothermal therapy effects; meanwhile, it could also give play to near-infrared fluorescence imaging (NIRFI) as well as photoacoustic imaging (PAI). Consequently, NIRFI and PAI from ICG combined with the MRI function of Gd, devoted to triple-modal imaging with success. At the same time, folic acid-modified thermosensitive liposomes were explored to be coated onto the surface of DOX@GdMSNs, to solve the DOX leakage as well as improve cellular uptake. Under NIR irradiation, ICG could generate heat, thus leading to the rupture of ICG-TSLs and the release of DOX. Accordingly, the multifunctional nanocomposite appeared to be a promising meritorious theranostic nanoplatform to pave a way for treating cancer.

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Crossref · 10.1021/acsami.7b13651

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  • Utilizing a duple of fluorescent and MRI agents, high sensitivity of fluorescent was accompanied by MRI's aptitude for deep-tissue imaging and high spatial and temporal resolution.

    “Utilizing a duple of fluorescent and MRI agents, the high sensitivity of the fluorescent was accompanied by the MRI’s aptitude for deep-tissue imaging and high spatial and temporal resolution [142,143].”

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Authors
Sun, Q., You, Q., Wang, J., Liu, L., Wang, Y., Song, Y., Cheng, Y., Wang, S., Tan, F., & Li, N.
Affiliations
Tianjin University (CN)
Corresponding author
Li, Nan
Venue
ACS Applied Materials & Interfaces
Published
2018-01-04
Volume
10
Issue
2
Pages
1963-1975
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2781408030
Cited by
109
References
44
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 23 · 2020: 15 · 2019: 19 · 2018: 11
FWCI
5.54
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Science and Technology of the People's Republic of China (2014CB932200)
  • National Natural Science Foundation of China (81503016)
  • Application Foundation and Cutting-edge Technologies Research Project of Tianjin (15JCQNJC13800)
  • Peiyang Young Talent Fund, Tianjin University (1701)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
mesoporous silica nanoparticles, gadolinium doping, theranostic nanocomposites, indocyanine green, thermosensitive liposomes, doxorubicin, near-infrared fluorescence imaging, photoacoustic imaging, photothermal therapy, photodynamic therapy, drug leakage, cancer therapy
MeSH terms
Theranostic Nanomedicine, Doxorubicin, Humans, Liposomes, Neoplasms, Phototherapy, Silicon Dioxide, Nanoparticles

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