Theranostic Nanoplatform: Triple-Modal Imaging-Guided Synergistic Cancer Therapy Based on Liposome-Conjugated Mesoporous Silica Nanoparticles
Abstract
Mesoporous silica nanoparticles (MSNs) have long since been investigated to provide a versatile drug-delivery platform due to their multitudinous merits. Presently, gadolinium (Gd), a T1 magnetic resonance imaging (MRI) contrast agent, was doped into MSNs as a newly emerging theranostic nanocomposite, which has received much research attention. However, it is still concerned about the dispersibility and drug leakage of MSNs. Hence, in this project, we constructed an near-infrared (NIR) irradiation-triggered, triple-modal imaging-guided nanoplatform based on doxorubicin (DOX)@Gd-doped MSNs, conjugating with indocyanine green (ICG)-loaded thermosensitive liposomes (designated as DOX@GdMSNs-ICG-TSLs). In this platform, ICG could contribute to both photodynamic therapy and photothermal therapy effects; meanwhile, it could also give play to near-infrared fluorescence imaging (NIRFI) as well as photoacoustic imaging (PAI). Consequently, NIRFI and PAI from ICG combined with the MRI function of Gd, devoted to triple-modal imaging with success. At the same time, folic acid-modified thermosensitive liposomes were explored to be coated onto the surface of DOX@GdMSNs, to solve the DOX leakage as well as improve cellular uptake. Under NIR irradiation, ICG could generate heat, thus leading to the rupture of ICG-TSLs and the release of DOX. Accordingly, the multifunctional nanocomposite appeared to be a promising meritorious theranostic nanoplatform to pave a way for treating cancer.
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Utilizing a duple of fluorescent and MRI agents, high sensitivity of fluorescent was accompanied by MRI's aptitude for deep-tissue imaging and high spatial and temporal resolution.
“Utilizing a duple of fluorescent and MRI agents, the high sensitivity of the fluorescent was accompanied by the MRI’s aptitude for deep-tissue imaging and high spatial and temporal resolution [142,143].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [143]
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Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
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“Utilizing a duple of fluorescent and MRI agents, the high sensitivity of the fluorescent was accompanied by the MRI’s aptitude for deep-tissue imaging and high spatial and temporal resolution [142,143].”
BackgroundYanar, F., Carugo, D., & Zhang, X. (2023) · Molecules · doi:10.3390/molecules28155694 · Cited by 80 · see citing works
de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71 · see citing works
- Authors
- Sun, Q., You, Q., Wang, J., Liu, L., Wang, Y., Song, Y., Cheng, Y., Wang, S., Tan, F., & Li, N.
- Affiliations
- Tianjin University (CN)
- Corresponding author
- Li, Nan
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-01-04
- Volume
- 10
- Issue
- 2
- Pages
- 1963-1975
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2781408030
- Cited by
- 109
- References
- 44
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 23 · 2020: 15 · 2019: 19 · 2018: 11
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2014CB932200)
- National Natural Science Foundation of China (81503016)
- Application Foundation and Cutting-edge Technologies Research Project of Tianjin (15JCQNJC13800)
- Peiyang Young Talent Fund, Tianjin University (1701)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- mesoporous silica nanoparticles, gadolinium doping, theranostic nanocomposites, indocyanine green, thermosensitive liposomes, doxorubicin, near-infrared fluorescence imaging, photoacoustic imaging, photothermal therapy, photodynamic therapy, drug leakage, cancer therapy
- MeSH terms
- Theranostic Nanomedicine, Doxorubicin, Humans, Liposomes, Neoplasms, Phototherapy, Silicon Dioxide, Nanoparticles
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