Hybrid Nanoplatforms Comprising Organic Nanocompartments Encapsulating Inorganic Nanoparticles for Enhanced Drug Delivery and Bioimaging Applications
Open accessAbstract
Organic and inorganic nanoparticles (NPs) have attracted significant attention due to their unique physico-chemical properties, which have paved the way for their application in numerous fields including diagnostics and therapy. Recently, hybrid nanomaterials consisting of organic nanocompartments (e.g., liposomes, micelles, poly (lactic-co-glycolic acid) NPs, dendrimers, or chitosan NPs) encapsulating inorganic NPs (quantum dots, or NPs made of gold, silver, silica, or magnetic materials) have been researched for usage in vivo as drug-delivery or theranostic agents. These classes of hybrid multi-particulate systems can enable or facilitate the use of inorganic NPs in biomedical applications. Notably, integration of inorganic NPs within organic nanocompartments results in improved NP stability, enhanced bioavailability, and reduced systemic toxicity. Moreover, these hybrid nanomaterials allow synergistic interactions between organic and inorganic NPs, leading to further improvements in therapeutic efficacy. Furthermore, these platforms can also serve as multifunctional agents capable of advanced bioimaging and targeted delivery of therapeutic agents, with great potential for clinical applications. By considering these advancements in the field of nanomedicine, this review aims to provide an overview of recent developments in the use of hybrid nanoparticulate systems that consist of organic nanocompartments encapsulating inorganic NPs for applications in drug delivery, bioimaging, and theranostics.
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Stimulus-responsive systems enable precise and controlled delivery of radioactive agents to the desired site and facilitate real-time monitoring and feedback of drug distribution and effects.
“These systems enable precise and controlled delivery of radioactive agents to the desired site and facilitate real-time monitoring and feedback of drug distribution and effects [29].”
From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [29]
Section 5 describes targeted delivery, trigger-controlled payload release, and imaging capabilities, including real-time ultrasound imaging. It does not establish delivery of radioactive agents or real-time feedback on drug distribution and effects; the radiosensitization example in Section 5.1 is not radioactive-agent delivery. Page numbers were not available in our copy. (LLM, conf=0.86)
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- Authors
- Yanar, F., Carugo, D., & Zhang, X.
- Affiliations
- Boğaziçi University (TR)
- University of Oxford (GB)
- University of Southampton (GB)
- Corresponding author
- Yanar, Fatih
- Zhang, Xunli
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2023-07-27
- Volume
- 28
- Issue
- 15
- Pages
- 5694
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC10420199
- OpenAlex
- W4385346814
- Cited by
- 80
- References
- 107
- Citations by year
- 2026: 32 · 2025: 27 · 2024: 16 · 2023: 5
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- hybrid nanostructures, inorganic nanoparticles, drug delivery, bioimaging, theranostics, liposomes, micelles, PLGA nanoparticles, dendrimers, chitosan nanoparticles, quantum dots, magnetic nanoparticles, silica nanoparticles, nanoparticle stability, targeted delivery, nanomedicine
- MeSH terms
- Liposomes, Drug Delivery Systems, Nanostructures, Nanomedicine, Nanoparticles
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