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A Nonconventional Archaeal Fluorinase Identified by In Silico Mining for Enhanced Fluorine Biocatalysis
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Earlier studies strongly indicate that fluoride anion toxicity is a major impediment to progress in both organofluorine synthesis and degradation.
“Earlier studies on biological organofluorine synthesis and degradation strongly indicate that fluoride anion toxicity is a major impediment to progress in both fields of study21,55,63,64.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [55]
The effects of F− salts on the physiology of Pseudomonas putida remained unstudied prior to this work.
“yet the effects of these salts on the bacterial physiology remain unstudied”
From Role of the CrcB transporter of Pseudomonas putida in the multi‐level stress response elicited by mineral fluoride (2022) · cites this paper as Pardo et al., 2022
Fluorinase has low kcat values up to 0.4 min−1.
“However, fluorinase also has limitations for biosynthesis, including low kcat values (up to 0.4 min−1)55 and high Km values for fluoride (2 mM for the well-studied S. cattleya enzyme)20.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [55]
Fluoroacetate synthesis in P. putida KT2440 was achieved by harnessing natural fluoride response elements to deliver fluoride to the cells in a controlled manner.
“Likewise, fluoroacetate synthesis in P. putida KT2440 was achieved by harnessing natural fluoride response elements to deliver fluoride to the cells in a controlled manner55.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [55]
A range of other fluorinase enzymes have been tested but so far none show markedly different steady-state kinetic parameters.
“A range of other fluorinase enzymes have been tested but so far, none show markedly different steady-state kinetic parameters55.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [55]
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Cites
Contribution of Organofluorine Compounds to Pharmaceuticals
Inoue, M., Sumii, Y., & Shibata, N. (2020) · ACS Omega · doi:10.1021/acsomega.0c00830 · Cited by 1,944
Current Contributions of Organofluorine Compounds to the Agrochemical Industry
Ogawa, Y., Tokunaga, E., Kobayashi, O., Hirai, K., & Shibata, N. (2020) · iScience · doi:10.1016/j.isci.2020.101467 · Cited by 1,253
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Stockbridge, R. B., & Wackett, L. P. (2024) · Nature Communications · doi:10.1038/s41467-024-49018-1 · Cited by 80
Calero, P., Gurdo, N., & Nikel, P. I. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16110 · Cited by 56
Self-citationEts, L., Ilves, H., Juhe, L., Ilmjärv, T., Puiggené, Ò., Nikel, P. I., & Kivisaar, M. (2026) · Journal of Bacteriology · doi:10.1128/jb.00479-25 · Cited by 1
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Metadata
- Authors
- Pardo, I., Bednar, D., Calero, P., Volke, D. C., Damborský, J., & Nikel, P. I.
- Venue
- ACS Catalysis
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-05-19
- Volume
- 12
- Issue
- 11
- Pages
- 6570-6577
- ISSN
- 2155-5435
- PMC
- PMC9173684
- Cited by
- 68
- References
- 2
- Language
- en
- Funders
- European Regional Development Fund (INBIO CZ.02.1.01/0.0/0.0/16_026/0008451)
- H2020 Leadership in Enabling and Industrial Technologies (814418)
- Grantov? Agentura Cesk? Republiky (DB 20-15915Y)
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