Bioactive Compounds of Arthrospira spp. (Spirulina) with Potential Anticancer Activities: A Systematic Review

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation

Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & the PRISMA-P Group (2015) · BMJ · doi:10.1136/bmj.g7647 · Cited by 13,120 · see citing works

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

Newman, D. J., & Cragg, G. M. L. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01285 · Cited by 7,153 · see citing works

Cancer drug resistance: an evolving paradigm

Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681 · see citing works

The Global Burden of Cancer 2013

Fitzmaurice, C., Dicker, D., Pain, A. W., Hamavid, H., Moradi‐Lakeh, M., MacIntyre, M. F., Allen, C., Hansen, G. M., Woodbrook, R., Wolfe, C. D. A., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.0735 · Cited by 2,709 · see citing works

Qualitative research synthesis: methodological guidance for systematic reviewers utilizing meta-aggregation

Lockwood, C., Munn, Z., & Porritt, K. (2015) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000062 · Cited by 2,456 · see citing works

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

Ouyang, L., Shi, Z., Zhao, S., Wang, F., Zhou, T., Liu, B., & Bao, J. (2012) · Cell Proliferation · doi:10.1111/j.1365-2184.2012.00845.x · Cited by 1,460 · see citing works

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

Sheng, H., Shao, J., Morrow, J. D., Beauchamp, R. D., & Dubois, R. N. (1998) · PubMed · Cited by 1,114 · see citing works

Drug resistance and combating drug resistance in cancer

Wang, X., Zhang, H., & Chen, X. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.10 · Cited by 1,105 · see citing works

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G 0 /G 1 -to-S-Phase Transition

Hinz, M., Krappmann, D., Eichten, A., Heder, A., Scheidereit, C., & Strauss, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2690 · Cited by 788 · see citing works

Nutritional and therapeutic potential of spirulina

Khan, Z., Bhadouria, P., & Bisen, P. (2005) · Current Pharmaceutical Biotechnology · doi:10.2174/138920105774370607 · Cited by 524 · see citing works

Hallmarks of glycosylation in cancer

Munkley, J., & Elliott, D. J. (2016) · Oncotarget · doi:10.18632/oncotarget.8155 · Cited by 518 · see citing works

Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases

Feng, S., & Chien, S. (2003) · Chemical Engineering Science · doi:10.1016/s0009-2509(03)00234-3 · Cited by 364 · see citing works

Polytherapy and Targeted Cancer Drug Resistance

Chatterjee, N., & Bivona, T. G. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.02.003 · Cited by 271 · see citing works

Links between apoptosis, proliferation and the cell cycle

Alenzi, F. Q. (2004) · British Journal of Biomedical Science · doi:10.1080/09674845.2004.11732652 · Cited by 254 · see citing works

Medical Application of Spirulina platensis Derived C‐Phycocyanin

Liu, Q., Huang, Y., Zhang, R.-H., Cai, T., & Cai, Y. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/7803846 · Cited by 213 · see citing works

Pharmaceutical applications of cyanobacteria—A review

Vijayakumar, S., & Menakha, M. (2015) · Journal of Acute Medicine · doi:10.1016/j.jacme.2015.02.004 · Cited by 205 · see citing works

Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds

Koníčková, R., Vaňková, K., Vaníková, J., Vanova, K. H., Lucie Muchova, A., Subhanová, I., Zadinová, M., Zelenka, J., Dvořák, A., Kolář, M., et al. (2014) · Annals of Hepatology · doi:10.1016/s1665-2681(19)30891-9 · Cited by 180 · see citing works

Marine cyanobacteria compounds with anticancer properties: A review on the implication of apoptosis

Costa, M., Costa-Rodrigues, J., Fernandes, M. H., Barros, P., Vasconcelos, V., & Martins, R. (2012) · Marine Drugs · doi:10.3390/md10102181 · Cited by 147 · see citing works

C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells

Jiang, L., Wang, Y., Liu, G., Liu, H., Zhu, F., Ji, H., & Li, B. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0511-5 · Cited by 138 · see citing works

Genetic aspects of inflammation and cancer

Hold, G. L., & El-Omar, E. M. (2008) · Biochemical Journal · doi:10.1042/bj20071341 · Cited by 136 · see citing works

Carotenoids, chlorophylls and phycocyanin from Spirulina: supercritical CO 2 and water extraction methods for added value products cascade

Marzorati, S., Schievano, A., Idà, A., & Verotta, L. (2019) · Green Chemistry · doi:10.1039/c9gc03292d · Cited by 134 · see citing works

Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy

Liao, G., Gao, B., Gao, Y., Yang, X., Cheng, X., & Ou, Y. (2016) · Scientific Reports · doi:10.1038/srep34564 · Cited by 120 · see citing works

The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo

Li, B., Gao, M., Chu, X., Teng, L., Lv, C.-Y., Yang, P., & Yin, Q.-F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.01.009 · Cited by 92 · see citing works

The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells

Hao, S., Yan, Y., Li, S., Zhao, L., Zhang, C., Liu, L., & Wang, C. (2018) · Marine Drugs · doi:10.3390/md16060178 · Cited by 81 · see citing works

Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells

Sannasimuthu, A., Kumaresan, V., Anilkumar, S., Pasupuleti, M., Munuswamy‐Ramanujam, G., Mala, K., Paray, B. A., Al‐Sadoon, M. K., Albeshr, M. F., & Arockiaraj, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.006 · Cited by 74 · see citing works

Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer

Tian, J., Hachim, M. Y., Hachim, I. Y., Dai, M., Lo, C., Raffa, F. A., Ali, S., & Lebrun, J. J. (2017) · Scientific Reports · doi:10.1038/srep40258 · Cited by 68 · see citing works

Immunotherapy of established micrometastases with Bacillus Calmette-Guérin tumor cell vaccine.

Hanna, M. G., & Peters, L. C. (1978) · PubMed · Cited by 66 · see citing works

Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds

Vidoni, C., Ferraresi, A., Secomandi, E., Vallino, L., Dhanasekaran, D. N., & Isidoro, C. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.04.006 · Cited by 54 · see citing works

Production and Nutritive Value of Arthrospira Platensis, a Spiral Blue-Green Alga Grown on Swine Wastes

Chung, P. Y. N., Pond, W. G., Kingsbury, J. M., Walker, E. F., & Krook, L. (1978) · Journal of Animal Science · doi:10.2527/jas1978.472319x · Cited by 48 · see citing works

C-Phycocyanin Suppresses the In Vitro Proliferation and Migration of Non-Small-Cell Lung Cancer Cells through Reduction of RIPK1/NF-κB Activity

Hao, S., Li, S., Wang, J., Zhao, L., Yan, Y., Wu, T., Zhang, J., & Wang, C. (2019) · Marine Drugs · doi:10.3390/md17060362 · Cited by 46 · see citing works

Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin

Saini, M. K., Vaiphei, K., & Sanyal, S. N. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1106-9 · Cited by 45 · see citing works

Transcriptome Analysis of Phycocyanin-Mediated Inhibitory Functions on Non-Small Cell Lung Cancer A549 Cell Growth

Hao, S., Li, S., Wang, J., Zhao, L., Yan, Y., Cao, Q., Wu, T., Liu, L., & Wang, C. (2018) · Marine Drugs · doi:10.3390/md16120511 · Cited by 45 · see citing works

Antioxidant molecular mechanism of adenosyl homocysteinase from cyanobacteria and its wound healing process in fibroblast cells

Sarkar, P., Raju, S. V., Pasupuleti, M., Paray, B. A., Al‐Sadoon, M. K., & Arockiaraj, J. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05276-y · Cited by 44 · see citing works

Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells

Pan, R., Lu, R., Zhang, Y., Zhu, M., Zhu, W., Yang, R., Zhang, E., Ying, J., Xu, T., Yi, H., et al. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.09.039 · Cited by 43 · see citing works

Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/β-catenin signaling while up-regulating ligand dependent transcription factor PPARγ

Saini, M. K., & Sanyal, S. N. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.03.007 · Cited by 42 · see citing works

Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies

Peinado, F. M., Artacho‐Cordón, F., Barrios‐Rodríguez, R., & Arrebola, J. P. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109561 · Cited by 41 · see citing works

Photodynamic effect and mechanism study of selenium-enriched phycocyanin from Spirulina platensis against liver tumours

Liu, Z., Fu, X., Huang, W., Li, C., Wang, X., & Huang, B. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.12.020 · Cited by 40 · see citing works

Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation

Ying, J., Wang, J., Ji, H., Lin, C., Pan, R., Zhou, L. Q., Song, Y., Zhang, E., Ren, P., Chen, J., et al. (2016) · Gene · doi:10.1016/j.gene.2016.03.023 · Cited by 39 · see citing works

Cell Cycle Regulation and Apoptotic Cell Death in Experimental Colon Carcinogenesis: Intervening with Cyclooxygenase-2 Inhibitors

Saini, M. K., & Sanyal, S. N. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1015743 · Cited by 37 · see citing works

PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat

Saini, M. K., & Sanyal, S. N. (2012) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2012.04.019 · Cited by 34 · see citing works

The potential of retinoids for combination therapy of lung cancer: Updates and future directions

Tripathi, S. K., Pandey, K., Panda, M., Spinella, M. J., Rengasamy, K. R. R., & Biswal, B. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104331 · Cited by 32 · see citing works

The Inhibitory Effect of C-phycocyanin Containing Protein Extract (C-PC Extract) on Human Matrix Metalloproteinases (MMP-2 and MMP-9) in Hepatocellular Cancer Cell Line (HepG2)

Kunte, M., & Desai, K. B. (2017) · The Protein Journal · doi:10.1007/s10930-017-9707-0 · Cited by 31 · see citing works

Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis

Saini, M. K., Vaish, V., & Sanyal, S. N. (2012) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3283584932 · Cited by 30 · see citing works

Apoptotic potential of C-phycoerythrin from Phormidium sp. A27DM and Halomicronema sp. A32DM on human lung carcinoma cells

Madamwar, D., Patel, D., Desai, S., Upadhyay, K. K., & Devkar, R. V. (2015) · EXCLI journal · doi:10.17179/excli2014-696 · Cited by 26 · see citing works

Piroxicam and C-Phycocyanin Mediated Apoptosis in 1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis: Exploring the Mitochondrial Pathway

Saini, M. K., Sanyal, S. N., & Vaiphei, K. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.655402 · Cited by 25 · see citing works

Anti-tumor effect of C-phycocyanin from Anabaena sp.ISC55 in inbred BALB/c mice injected with 4T1 breast cancer cell

Moghaddam, F. D., Hamedi, S., & Dezfulian, M. (2016) · Comparative Clinical Pathology · doi:10.1007/s00580-016-2285-2 · Cited by 20 · see citing works

Anti‐angiogenic effects of the blue‐green alga Arthrospira platensis on pancreatic cancer

Markova, I., Koníčková, R., Vaňková, K., Leníček, M., Kolář, M., Strnad, H., Hradilová, M., Šáchová, J., Rasl, J., Klímová, Z., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14922 · Cited by 19 · see citing works

Effect of nutritional factors on the culture of Nostoc sp. as a source of phycobiliproteins

Silva, H., Corti�as, T., & Ertola, R. (1989) · Applied Microbiology and Biotechnology · doi:10.1007/bf00258412 · Cited by 16 · see citing works

Effect of photodynamic therapy with (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt on pancreatic cancer cells in vitro and in vivo

Shen, Y., Cao, J., Sun, F., Cai, X.-L., Li, M.-M., Zheng, N.-N., Qu, C., Zhang, Y., Shen, F., Zhou, M., et al. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i46.5246 · Cited by 12 · see citing works

Peroxiredoxin of Arthrospira platensis derived short molecule YT12 influences antioxidant and anticancer activity

Sannasimuthu, A., Ramani, M., Pasupuleti, M., Saraswathi, N. T., Arasu, M. V., Al-Dhabi, N. A., Arshad, A., Mala, K., & Arockiaraj, J. (2020) · Cell Biology International · doi:10.1002/cbin.11431 · Cited by 10 · see citing works

The apoptosis pathway of photodynamic therapy using 9-HpbD-a in AMC-HN3 human head and neck cancer cell line and in vivo

Ahn, J. (2014) · General Physiology and Biophysics · doi:10.4149/gpb_2013040 · Cited by 8 · see citing works

Synergistic effect of co-treatment with all-trans retinoic acid and 9-cis retinoic acid on human lung cancer cell line at molecular level

Bama, E. S., Grace, V. M. B., Sundaram, V., & Jesubatham, P. D. (2019) · 3 Biotech · doi:10.1007/s13205-019-1692-x · Cited by 8 · see citing works

Arthrospira platensis Mediated Biosynthesis of Silver Nanoparticles as Breast Cancer Proliferation and Differentiation Controlling agent: In-vitro and In-vivo Safety ApproachPreprint

Deeb, N. E., Abo-Eleneen, M. A., Awad, O. A., & Abo-Shady, A. M. (2021) · Research Square · doi:10.21203/rs.3.rs-382873/v1 · Cited by 5 · see citing works

The costs of cancer drugs

Begg, C. B. (2020) · Clinical Trials · doi:10.1177/1740774520907662 · Cited by 4 · see citing works

Cytotoxic Potential of Arthrospira platensis Extract on Cervical Cancer Cells Line Hela: Study on Antiproliferative, Cell Cycle, Apoptosis Induction and Anti Metastasis

Nurani, L. H., Mahfudh, N., Gandjar, I. G., & Rahayu, I. (2020) · INDONESIAN JOURNAL OF PHARMACY · doi:10.14499/indonesianjpharm31iss1pp19 · Cited by 4 · see citing works

Apoptotic potential of C-phycoerythrin from Phormidium sp. A27DM and Halomicronema sp. A32DM on human lung carcinoma cellsApoptotic potential of C-phycoerythrin from Phormidium sp. A27DM and Halomicronema sp. A32DM on human lung carcinoma cells

Madamwar, D., Patel, D., Desai, S., Upadhyay, K. K., & Devkar, R. (2015) · Technische Universität Dortmund Eldorado (Technische Universität Dortmund) · doi:10.17877/de290r-17048 · Cited by 3 · see citing works

Advances in Nutrition and Food science

(2020) · Advances in Nutrition and food science · doi:10.37722/anafs · Cited by 3 · see citing works

Chemical Composition, Bioactivities, and Applications of Spirulina (Limnospira platensis) in Food, Feed, and Medicine

Spínola, M. P., Mendes, A. R., & Prates, J. A. M. (2024) · Foods · doi:10.3390/foods13223656 · Cited by 146 · see citing works

Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.

Abreu, A. P., Martins, R., & Nunes, J. (2023) · Bioengineering · doi:10.3390/bioengineering10080955 · Cited by 119 · see citing works

Advances in Genetic Engineering in Improving Photosynthesis and Microalgal Productivity

Hu, J., Wang, D., Chen, H., & Wang, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031898 · Cited by 67 · see citing works

Mechanistic insights into the nutritional and therapeutic potential of Spirulina (Arthrospira) spp.: Challenges and opportunities

Shah, M. A. R., Zhu, F., Cui, Y., Hu, X., Chen, H., Kayani, S., & Huo, S. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104648 · Cited by 56 · see citing works

Spirulina/Arthrospira/Limnospira—Three Names of the Single Organism

Sinetova, M. A., Kupriyanova, E. V., & Los, D. A. (2024) · Foods · doi:10.3390/foods13172762 · Cited by 51 · see citing works

Fluorescence and antioxidant activity of heterologous expression of phycocyanin and allophycocyanin from Arthrospira platensis

Shang, M., Sun, J.-F., Bi, Y., Xu, X., & Zang, X. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1127422 · Cited by 46 · see citing works

Effects of spirulina Spirulina platensis meal as a feed additive on growth performance and immunological response of Gangetic mystus Mystus cavasius

Mamun, M. A., Hossaın, M. A., Saha, J., Khan, S., Akter, T., & Banu, M. R. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101553 · Cited by 40 · see citing works

Effects of dietary supplementation of natural Spirulina on growth performance, hemato-biochemical indices, gut health, and disease resistance to Aeromonas hydrophila of Stinging catfish (Heteropneustes fossilis) fingerling

Rahman, M., Mamun, M. A. A., Rathore, S. S., Nandi, S. K., Kari, Z. A., Wei, L. S., Tahiluddin, A. B., Rahman, M. M., Manjappa, N. K., Hossain, A., et al. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101727 · Cited by 38 · see citing works

Spirulina platensis: A comprehensive review of its nutritional value, antioxidant activity and functional food potential

Sahil, S., Bodh, S., & Verma, P. (2024) · Journal of Cellular Biotechnology · doi:10.3233/jcb-240151 · Cited by 36 · see citing works

Biological sources, metabolism, and production of glucosylglycerols, a group of natural glucosides of biotechnological interest

Luo, Q., Duan, Y., & Lü, X. (2022) · Biotechnology Advances · doi:10.1016/j.biotechadv.2022.107964 · Cited by 32 · see citing works

Antioxidant, immunomodulatory, and anti-inflammatory effects of Spirulina in disease conditions: a systematic review

Calella, P., Dio, M. D., Cerullo, G., Onofrio, V. D., Gallé, F., & Liguori, G. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2137785 · Cited by 29 · see citing works

The Development of Live Microorganism-Based Oxygen Shuttles for Enhanced Hypoxic Tumor Therapy

Han, D., Zhang, X., Ma, Y., Yang, X., & Li, Z. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100517 · Cited by 25 · see citing works

Antitumor lectins from algae: A systematic review

de Arruda, M. C. S., da Silva, M. R. O. B., Cavalcanti, V. L. R., Brandão, R., Marques, D. D. A. V., de Lima, L. R. A., Porto, A. L. F., & Bezerra, R. P. (2023) · Algal Research · doi:10.1016/j.algal.2022.102962 · Cited by 21 · see citing works

Integrated deep eutectic solvent (DES) extraction and microwave-assisted process for algal protein extraction: Process improvement, characterizations, functional properties, and antioxidant and anti-colorectal cancer potentials

Zin, M. T., Kaewkod, T., Pekkoh, J., ., W. P.-A., Chaipoot, S., Kanthakat, G., Seesuriyachan, P., Chen, Y.-Y., Khoo, K. S., Cheirsilp, B., et al. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101673 · Cited by 21 · see citing works

The Cyanobacterial “Nutraceutical” Phycocyanobilin Inhibits Cysteine Protease Legumain

Wilkinson, I. V. L., Castro‐Falcón, G., Roda‐Serrat, M. C., Purdy, T. N., Straetener, J., Brauny, M., Maier, L., Brötz‐Oesterhelt, H., Christensen, L. P., Sieber, S. A., et al. (2022) · ChemBioChem · doi:10.1002/cbic.202200455 · Cited by 13 · see citing works

Exploring the Nutritional and Medicinal potential of Spirulina

Gaur, K., Wal, A., Sharma, P., Parveen, A., Singh, P. P., Mishra, P., Wal, P., & Mishra, N. T. P. (2024) · Natural Resources for Human Health · doi:10.53365/nrfhh/188021 · Cited by 12 · see citing works

Characterization of Spirulina‐derived extracellular vesicles and their potential as a vaccine adjuvant

Sharifpour, M. F., Sıkder, S., Wong, Y., Koifman, N., Thomas, T., Courtney, R. L., Seymour, J., & Loukas, A. C. (2024) · Journal of Extracellular Biology · doi:10.1002/jex2.70025 · Cited by 10 · see citing works

Probiotics and Spirulina platensis Improved Growth Performance of Nile Tilapia ( Oreochromis niloticus ) by Upgrading Intestinal Morphology and Activating GH/IGF Axis

Islam, M., Khanom, H., Islam, N., Fariha, F., Paray, B. A., Zahangir, M. M., & Shahjahan, M. (2025) · Aquaculture Research · doi:10.1155/are/1839162 · Cited by 8 · see citing works

Microalgal production under mixotrophic conditions using cheese whey as substrate

de Andrade, A. F., Silva, P. E. D. C. E., de Melo, R. G., Ferreira, M. P. D. N., Porto, A. L. F., & Bezerra, R. P. (2022) · Acta Scientiarum Biological Sciences · doi:10.4025/actascibiolsci.v44i1.62512 · Cited by 8 · see citing works

miR-3150a-3p, miR-6883-3p and miR-627-5p participate in the phycocyanin-mediated growth diminishment of A549 cells, via regulating a common target toll/interleukin 1 receptor domain-containing adaptor protein

Hao, S., Li, F., Li, S., Li, Q., Liu, Y., Yang, Q., Ye, X., & Wang, C. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105011 · Cited by 8 · see citing works

Whey protein and flaxseed gum co-encapsulated fucoxanthin promoted tumor cells apoptosis based on MAPK-PI3K/Akt regulation on Huh-7 cell xenografted nude mice

Wang, C., Huang, X., Sun, K., Li, X., Feng, D., Nakamura, Y., & Qi, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134838 · Cited by 7 · see citing works

C-Phycocyanin induces apoptosis in oral squamous cell carcinoma KB cells via modulation of key molecular pathways

Asoudeh-Fard, A., Salehi, M., Mirhashemi, M., Fathi, M., Emami, A., Soltanmohammadi, F., Parsaei, A., & Piri, H. (2025) · Medical Oncology · doi:10.1007/s12032-025-02886-z · Cited by 7 · see citing works

Critical appraisal tools used in systematic reviews of in vitro cell culture studies: A methodological study

Barbosa, V. P., Silveira, B. B., dos Santos, J. A., Monteiro, M. M., Coletta, R. D., Canto, G. D. L., Stefani, C. M., & Guerra, E. N. S. (2023) · Research Synthesis Methods · doi:10.1002/jrsm.1657 · Cited by 7 · see citing works

Mychonastes sp. 246 Suppresses Human Pancreatic Cancer Cell Growth via IGFBP3-PI3K-mTOR Signaling

Jang, H., Lee, S., Hong, E., Yim, K. J., Choi, Y., Jung, J. Y., & Kim, Z. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2211.11010 · Cited by 6 · see citing works

Spirulina-coenzyme Q10 nanoemulsion regulating growth, antioxidant, immune capacity, histopathological alterations in Nile tilapia exposed to heat stress

Ahmed, S. A. A., El-Houseiny, W., El-Hady, M., Metwally, M. M. M., Ismail, S. H., & El‐Shahat, W. (2026) · Scientific Reports · doi:10.1038/s41598-026-36000-8 · Cited by 4 · see citing works

Botanical remedies ameliorate oxidative stress, immune response, and histopathology in Clarias gariepinus exposed to pyrogallol

Hamed, M., Said, R. E. M., Kotob, M. H., & Sayed, A. E. H. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126628 · Cited by 4 · see citing works

S-adenosylmethionine synthase-derived GR15 peptide suppresses proliferation of breast cancer cells by upregulating the caspase-mediated apoptotic pathway: In vitro and in silico analyses

Velayutham, M., Haridevamuthu, B., Elsadek, M. F., Rizwana, H., Juliet, A., Karuppiah, K. M., & Arockiaraj, J. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.102354 · Cited by 4 · see citing works

Therapeutical Potential and Immunomodulatory Profile of Arthrospira platensis Compounds against Chagas Disease

da Silva, M. R. O. B., da Silva, A. C., Torreão, B. D. C., Costa, R. M. P. B., Bezerra, R. P., da Silva, S. D. F. F., Oliva, M. L. V., Xavier, L. S. D. S., Viana, I. F. T., Lins, R. D., et al. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c01052 · Cited by 3 · see citing works

Pre-clinical evidence for plant and insect proteins in supporting growth and bone development

Becker, G., Janssen, J. N., Kalev‐Altman, R., Meilich, D., Shitrit-Tovli, A., Penn, S., Reifen, R. M., & Ornan, E. M. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100504 · Cited by 6 · see citing works

Nanoencapsulation of protein-rich Spirulina biomass: New frontiers for superfoods — A review

Rasia, T. A., Vaz, B. D. S., Costa, J. A. V., & de Morais, M. G. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107587 · Cited by 2 · see citing works

Phycocyanin a nutraceutical with antioxidant activity

Fernández-Rojas, B., Hernández‐Juárez, J., & Pedraza‐Chaverrí, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21873-6.00004-x · Cited by 2 · see citing works

Computational POM and DFT evaluation of phycocyanin and its derivatives as a potential anticancer agent

Sabbahi, R., Youssoufi, M. H., Azzaoui, K., Hammouti, B., Chetouani, A., Saoiabi, S., & Zgou, H. (2022) · Materials Today Proceedings · doi:10.1016/j.matpr.2022.08.535 · Cited by 1 · see citing works

Co-administration of Spirulina and L-carnitine preserves ovarian reserve in a rat model of premature ovarian insufficiency via SIRT1 regulation of oxidative stress, inflammation, and apoptosis

Embaby, E. M., Elshopakey, G. E., Megahed, A., Rezk, S., Ateya, A. I., Eldesoqui, M. B., Yousef, E. H., & Elghareeb, M. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-11143-2 · Cited by 1 · see citing works

Assessment of the Use of Coconut Water as a Cultivation Medium for Limnospira (Arthrospira) platensis (Gomont): Effects on Productivity and Phycocyanin Concentration

da Silva, M. R. O. B., do Nascimento, B. E. G., Mendes, M. E. M., da Silva, R. O. B., Caires, S. D. F. F. D. S., Costa, R. M. P. B., & Marques, D. D. A. V. (2025) · Phycology · doi:10.3390/phycology5040082 · Cited by 1 · see citing works

Fibrinolytic enzyme from Arthrospira platensis and its effects on breast cancer cells: Exploring its potential as an innovative therapy

Moura, Y. A. S., da Silva, M. M., da Silva, S. C., Nascimento, T. P., Leite, A. C. L., do Couto, M. T. T., Nogueira, M. C. D. B. L., Rocha, T. A., Porto, A. L. F., & Bezerra, R. P. (2025) · Biochimie · doi:10.1016/j.biochi.2024.12.013 · Cited by 1 · see citing works

Therapeutic applications of Arthrospira sp. in human health: An overview

da Silva, M. R. O. B., da Silva, R. O. B., do Nascimento, B. E. G., Ramos, D. G., Mendes, M. E. M., da Silva, S. D. F. F., Costa, R. M. P. B., & Marques, D. D. A. V. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.07.041 · Cited by 3 · see citing works

The Therapeutic Importance of Oxy+: An Overview

Alam, M. A., Eqbal, K., Ahmad, I., Sofi, G., Rahman, M. A., & Alam, M. (2024) · Hippocratic Journal of Unani Medicine · doi:10.4103/hjum.hjum_53_25 · Cited by 1 · see citing works

Sub-Aerial Cyanobacteria: A Survey of Research with Antimicrobial Properties for Pharmaceutical Approaches

Singh, L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102696

Algal bioreactors for phycoprospecting: An emphasis on algae culturing

Krishnan, V., Shanmugam, K., Beaula, W. S., Raja, R., Singaravelu, P., Ranishree, J. K., & Cherifi, O. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-14058-7.00037-3

Preparation and evaluation of antioxidant activity of Spirulina platensis extraction: Potential application in cancer prevention and treatment

Hamadi, A. A., & Fajer, A. N. (2024) · Asia-Pacific Journal of Molecular Biology and Biotechnology · doi:10.35118/apjmbb.2024.032.4.18

Spirulina: Nutritional supplement potential for adults and athletes – a literature review

Orak, G., & Canbolat, E. (2025) · Food and Health · doi:10.3153/fh25024

Novel Therapeutic and Diagnostic Applications of Microalgal Phycobiliproteins

Ramya, R., Ramila, R., Thangarani, A. J., Shanmugam, S. A., & Kathirvelpandian, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-05253-7_10

EVALUATION OF VITAMIN-C AND SPIRULINA (ARTHROSPIRA PLATENSIS) SUPPELENTATION DIET ON GROWTH PERFORMANCE, ANTI-OXIDANTS AND CARCASS COMPOSITION OF ROHU, LABEO ROHITA (HAMILTON, 1822)

Damle, R., Singh, M., Lal, J., & Damle, D. K. (2025) · International Journal of Research -GRANTHAALAYAH · doi:10.29121/granthaalayah.v14.i1.2026.6674

61124 Modern techniques leading to bioactive compound discoveries in microorganisms: case studies

Jha, A. N., Gaikwad, V. R., Mulla, T., Asar, M., & Sindhu, R. K. (2026) · De Gruyter eBooks · doi:10.1515/9783111628240-029

Microalgae: impacts of different culture media on the macromolecular and antioxidant properties of spirulina ( Arthrospira platensis ) biomass

Martins, A., João, J. J., Canto, F. Q., Skoronski, É., Willemann, D. P., & Neves, F. D. F. (2025) · International Journal of Food Science & Technology · doi:10.1093/ijfood/vvaf275

Influence of Hydrothermal Carbonization By-Products from Olive Mill Waste on Chlorella vulgaris and Arthrospira platensis Cultures Devoted to Biogas Upgrading

de Mello, B. S., Vargas-Estrada, L., Sarti, A., & Muñoz, R. (2026) · BioEnergy Research · doi:10.1007/s12155-026-11018-y

Spirulina (Arthrospira spp.): Nutritional value, bioactive compounds profile, extraction methods, health functions, and potential applications in food industry

Assen, K. A., Gemede, H. F., & Hassen, S. M. (2026) · Food Research International Reports · doi:10.1016/j.frinr.2026.100009

Potential health aspect of fermented Spirulina product with Lacticaseibacillus rhamnosus

Kavak, A. E., Özçimen, D. B., & Sağdıç, O. (2026) · Biotechnology Letters · doi:10.1007/s10529-026-03770-0

Potential of Dietary Microalgae as Feed Additive in Japanese Quail

Fatima, T., Tahir, M., Hameed, A., Shahzadi, F., Naz, S., Sajjad, A., & Manzoor, M. (2026) · Veterinary Medicine International · doi:10.1155/vmi/6641503

Hydrolysis of Arthrospira platensis proteins: alcalase-flavourzyme combination enhances bioactive peptide production

Samimiazad, A., Mirdamadi, S., & Safavi, M. (2026) · Applied Food Research · doi:10.1016/j.afres.2026.102732

EVOO and Spirulina‐Based Condiment: Exploring the Chemical Composition by SPME‐GC/MS, GC/MS, and NMR Analysis with Sensory Profile and Bioactivity Assessment

Costantini, L., Frangipane, M. T., Frangipane, M. T., Matteo, G. D., Merendino, N., Massantini, R., Mannina, L., & Garzoli, S. (2026) · ChemistrySelect · doi:10.1002/slct.74902

Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies

Braune, S., Krüger‐Genge, A., Kammerer, S., Jung, F., & Küpper, J. (2021) · Life · doi:10.3390/life11020091 · Cited by 114 · see citing works

Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential

Akrout, R., Ayed, K., Mrizak, H., Leloup, L., Kenou, O. M., Fassinou, F., Bacha, D., Boughriba, R., Attia, H., Kovacic, H., et al. (2026) · Medical Sciences · doi:10.3390/medsci14020189 · Cited by 1 · see citing works

Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights

Bouyahya, A., Bakrim, S., Chamkhi, I., Taha, D., Omari, N. E., Mneyiy, N. E., Hachlafi, N. E., El‐Shazly, M., Khalid, A., Abdalla, A. N., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115989 · Cited by 96 · see citing works

SPIRULINA – A WONDER NUTRACEUTICAL AGAINST CANCER: A REVIEW

Kaur, K., & Kaur, S. (2021) · PLANT ARCHIVES · doi:10.51470/plantarchives.2021.v21.no1.177 · Cited by 2 · see citing works

Efectos citotóxicos sobre células tumorales de la Ficocianina extraída de microalgas

Gandía Almorox, R. (2021) · UPM Digital Archive (Technical University of Madrid)