The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells
Open accessAbstract
A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 °C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.
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Cites
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Cited by
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Self-citationFerroptosis: molecular mechanisms and health implications
Tang, D., Chen, X., Kang, R., & Kroemer, G. (2021) · Cell Research · doi:10.1038/s41422-020-00441-1 · Cited by 4,256
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
Stockwell, B. R. (2022) · Cell · doi:10.1016/j.cell.2022.06.003 · Cited by 3,056
Role of GPX4 in ferroptosis and its pharmacological implication
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Ferroptosis: Mechanisms and links with diseases
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Metadata
- Authors
- Abrams, R. P., Carroll, W. L., & Woerpel, K. A.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-03-01
- Volume
- 11
- Issue
- 5
- Pages
- 1305-1312
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W2258749495
- Cited by
- 187
- References
- 20
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
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