Ferroptosis: Mechanisms and links with diseases

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713 · see citing works

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,557 · see citing works

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works

Autophagy as a regulated pathway of cellular degradation.

Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703 · see citing works

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579 · see citing works

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works

Ischemia and reperfusion—from mechanism to translation

Eltzschig, H. K., & Eckle, T. D. L. G. (2011) · Nature Medicine · doi:10.1038/nm.2507 · Cited by 3,389 · see citing works

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341 · see citing works

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029 · see citing works

[44] Glutathione peroxidase

Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Wang, W., Green, M., Choi, J. E., Gijón, M., Kennedy, P. D., Johnson, J. K., Liao, P., Lang, X., Kryczek, I., Sell, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1170-y · Cited by 2,880 · see citing works

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works

Dendritic cells in cancer immunology and immunotherapy

Wculek, S. K., Cueto, F. J., Mujal, A. M., Melero, I., Krummel, M. F., & Sancho, D. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0210-z · Cited by 2,594 · see citing works

Characterization of Mammalian Selenoproteomes

Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,353 · see citing works

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329 · see citing works

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works

Self-consumption: the interplay of autophagy and apoptosis

Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172 · see citing works

Ferroptosis as a target for protection against cardiomyopathy

Fang, X., Wang, H., Han, D., Xie, E., Yang, X., Wei, J., Gu, S., Gao, F., Zhu, N., Yin, X., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821022116 · Cited by 2,142 · see citing works

Role of Mitochondria in Ferroptosis

Gao, M., Yi, J., Zhu, J., Minikes, A. M., Monian, P., Thompson, C. B., & Jiang, X. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.042 · Cited by 2,120 · see citing works

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works

Activation of the p62–Keap1–NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Sun, X., Ou, Z., Chen, R., Niu, X., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28251 · Cited by 2,012 · see citing works

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011 · see citing works

Free Radical Lipid Peroxidation: Mechanisms and Analysis

Yin, H., Xu, L., & Porter, N. A. (2011) · Chemical Reviews · doi:10.1021/cr200084z · Cited by 1,952 · see citing works

Glutathione peroxidases

Brigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904 · see citing works

Ferroptosis is an autophagic cell death process

Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899 · see citing works

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works

Doxorubicin-Induced Cardiomyopathy

Singal, P. K., & Iliskovic, N. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809243391307 · Cited by 1,848 · see citing works

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Hangauer, M. J., Viswanathan, V. S., Ryan, M. J., Bole, D., Eaton, J. K., Matov, A., Galeas, J., Dhruv, H. D., Berens, M. E., Schreiber, S. L., et al. (2017) · Nature · doi:10.1038/nature24297 · Cited by 1,799 · see citing works

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

Ingold, I., Berndt, C., Schmitt, S., Doll, S. G., Poschmann, G., Buday, K., Roveri, A., Peng, X., Freitas, F. P., Seibt, T., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.048 · Cited by 1,685 · see citing works

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631 · see citing works

Polyunsaturated fatty acids and their metabolites in brain function and disease

Bazinet, R. P., & Layé, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3820 · Cited by 1,613 · see citing works

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Liang, C., Zhang, X., Yang, M., & Dong, X. (2019) · Advanced Materials · doi:10.1002/adma.201904197 · Cited by 1,569 · see citing works

Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma

Morton, D. L., Thompson, J. F., Cochran, A. J., Mozzillo, N., Nieweg, O. E., Roses, D. F., Hoekstra, H. J., Karakousis, C. P., Puleo, C. A., Coventry, B. J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1310460 · Cited by 1,484 · see citing works

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470 · see citing works

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Dolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446 · see citing works

Oxidative stress and cancer: An overview

Iglesias, V. S., Moliné, T., Somoza, R., Paciucci, R., Kondoh, H., & LLeonart, M. E. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.10.004 · Cited by 1,445 · see citing works

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Lei, G., Zhang, Y., Koppula, P., Liu, X., Zhang, J., Lin, S. H., Ajani, J. A., Xiao, Q., Liao, Z., Wang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-019-0263-3 · Cited by 1,318 · see citing works

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Angeli, J. P. F., Krysko, D. V., & Conrad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0149-1 · Cited by 1,262 · see citing works

Biochemical, physiological and medical aspects of ubiquinone function

Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,227 · see citing works

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Magtanong, L., Ko, P., To, M., Cao, J. Y., Forcina, G. C., Tarangelo, A., Ward, C. C., Cho, K., Patti, G. J., Nomura, D. K., et al. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2018.11.016 · Cited by 1,168 · see citing works

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Manguso, R. T., Pope, H. W., Zimmer, M. D., Brown, F. D., Yates, K. B., Miller, B. C., Collins, N. B., Bi, K., LaFleur, M. W., Juneja, V. R., et al. (2017) · Nature · doi:10.1038/nature23270 · Cited by 1,147 · see citing works

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146 · see citing works

Energy-stress-mediated AMPK activation inhibits ferroptosis

Lee, H., Zandkarimi, F., Zhang, Y., Meena, J. K., Kim, J., Zhuang, L., Tyagi, S., Ma, L., Westbrook, T. F., Steinberg, G. R., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0461-8 · Cited by 1,138 · see citing works

Synchronized renal tubular cell death involves ferroptosis

Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126 · see citing works

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

Wu, J., Minikes, A. M., Gao, M., Bian, H., Li, Y., Stockwell, B. R., Chen, Z.-N., & Jiang, X. (2019) · Nature · doi:10.1038/s41586-019-1426-6 · Cited by 1,110 · see citing works

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,080 · see citing works

Identification of ACSL4 as a biomarker and contributor of ferroptosis

Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071 · cited 1× · see citing works

Ferroptosis is a type of autophagy-dependent cell death

Zhou, B., Liu, J., Kang, R., Klionsky, D. J., Kroemer, G., & Tang, D. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.03.002 · Cited by 1,071 · see citing works

Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11

Lang, X., Green, M. D., Wang, W., Yu, J., Choi, J. E., Jiang, L., Liao, P., Zhou, J., Zhang, Q., Dow, A., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0338 · Cited by 1,066 · see citing works

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

Zilka, O., Shah, R., Li, B., Angeli, J. P. F., Grießer, M., Conrad, M., & Pratt, D. A. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00028 · Cited by 1,052 · see citing works

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Dixon, S. J., Winter, G. E., Musavi, L. S., Lee, E. D., Snijder, B., Rebsamen, M., Superti-Furga, G., & Stockwell, B. R. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00245 · Cited by 1,043 · see citing works

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

Murphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. L., & COYLE, J. T. (1989) · Neuron · doi:10.1016/0896-6273(89)90043-3 · Cited by 1,033 · see citing works

The chemical basis of ferroptosis

Conrad, M., & Pratt, D. A. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0408-1 · Cited by 1,027 · see citing works

BAP1 links metabolic regulation of ferroptosis to tumour suppression

Zhang, Y., Shi, J., Liu, X., Li, F., Gong, Z., Koppula, P., Sirohi, K., Li, X., Wei, Y., Lee, H., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0178-0 · Cited by 1,024 · see citing works

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017 · see citing works

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Alim, I., Caulfield, J. T., Chen, Y., Swarup, V., Geschwind, D. H., Ivanova, E., Seravalli, J., Ai, Y., Sansing, L. H., Ste.Marie, E. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.032 · Cited by 1,016 · see citing works

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2696 · Cited by 981 · see citing works

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Wenzel, S. E., Tyurina, Y. Y., Zhao, J., Croix, C. M. S., Dar, H. H., Mao, G., Tyurin, V. A., Anthonymuthu, T. S., Kapralov, A. A., Amoscato, A. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.044 · Cited by 960 · see citing works

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.055 · Cited by 952 · see citing works

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

Tsoi, J., Robert, L., Paraiso, K., Galvan, C., Sheu, K. M., Lay, J., Wong, D. J. L., Atefi, M., Shirazi, R., Wang, X., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.017 · Cited by 938 · see citing works

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., & Gu, W. (2012) · Cell · doi:10.1016/j.cell.2012.04.026 · Cited by 912 · see citing works

Lymph protects metastasizing melanoma cells from ferroptosis

Ubellacker, J. M., Tasdogan, A., Ramesh, V., Shen, B., Mitchell, E. C., Martin-Sandoval, M. S., Gu, Z., McCormick, M. L., Durham, A. B., Spitz, D. R., et al. (2020) · Nature · doi:10.1038/s41586-020-2623-z · Cited by 902 · see citing works

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

Bogdan, A. R., Miyazawa, M., Hashimoto, K., & Tsuji, Y. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.11.012 · Cited by 897 · see citing works

Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy

Latunde-Dada, G. O. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.05.019 · Cited by 892 · see citing works

Transferrin Receptor Is a Specific Ferroptosis Marker

Feng, H., Schorpp, K., Jin, J., Yozwiak, C. E., Hoffstrom, B. G., Decker, A., Rajbhandari, P., Stokes, M. E., Bender, H. G., Csuka, J. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.049 · Cited by 891 · see citing works

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Zou, Y., Palte, M. J., Deik, A. A., Li, H., Eaton, J. K., Wang, W., Tseng, Y.-Y., Deasy, R., Kost-Alimova, M., Dančík, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09277-9 · Cited by 887 · see citing works

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

Chu, B., Kon, N., Chen, D., Li, T., Liu, T., Jiang, L., Song, S., Tavana, O., & Gu, W. J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0305-6 · Cited by 885 · see citing works

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang, L., Feng, D., Wang, Z., Zhao, Y., Sun, R., Tian, D., Liu, D., Zhang, F., Ning, S., Yao, J., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0299-4 · Cited by 872 · see citing works

[5] Diversity of glutathione peroxidases

Maiorino, F. M., Brigelius‐Flohé, R., Aumann, K. D., Roveri, A., Schomburg, D., & Flohé, L. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)52007-4 · Cited by 854 · see citing works

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

Hambright, W. S., Fonseca, R. S., Chen, L., Na, R., & Ran, Q. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.021 · Cited by 851 · see citing works

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Zou, Y., Henry, W. S., Ricq, E. L., Graham, E. T., Phadnis, V. V., Maretich, P., Paradkar, S., Boehnke, N., Deik, A., Reinhardt, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2732-8 · Cited by 849 · see citing works

Flavonoids Protect Neuronal Cells from Oxidative Stress by Three Distinct Mechanisms

Ishige, K., Schubert, D., & Sagara, Y. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00498-6 · Cited by 841 · see citing works

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

Stocker, R., Bowry, V. W., & Frei, B. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1646 · Cited by 794 · see citing works

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R. (2017) · Nature · doi:10.1038/nature24637 · Cited by 787 · see citing works

Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

Lee, J., Calkins, M. J., Chan, K., Kan, Y. W., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211558200 · Cited by 783 · see citing works

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782 · see citing works

ROS-Mediated Lipid Peroxidation and RES-Activated Signaling

Farmer, E. E., & Mueller, M. J. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120132 · Cited by 758 · see citing works

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

Feng, H., & Stockwell, B. R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006203 · Cited by 757 · see citing works

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Soula, M., Weber, R. A., Zilka, O., Alwaseem, H., La, K., Yen, F. S., Molina, H., García‐Bermúdez, J., Pratt, D. A., & Birsoy, K. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0613-y · Cited by 754 · see citing works

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Gaschler, M. M., Andia, A. A., Liu, H., Csuka, J. M., Hurlocker, B., Vaiana, C. A., Heindel, D. W., Zuckerman, D. S., Bos, P. H., Reznik, E., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0031-6 · Cited by 750 · see citing works

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

Kerins, M. J., & Ooi, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7176 · Cited by 741 · see citing works

The Regulation of Reactive Oxygen Species Production during Programmed Cell Death

Tan, S., Sagara, Y., Liu, Y., Maher, P. A., & Schubert, D. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.6.1423 · Cited by 730 · see citing works

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Zhang, Y., Tan, H., Daniels, J. D., Zandkarimi, F., Liu, H., Brown, L. M., Uchida, K., O’Connor, O. A., & Stockwell, B. R. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.01.008 · Cited by 729 · see citing works

Selenium and selenocysteine: roles in cancer, health, and development

Hatfield, D. L., Tsuji, P. A., Carlson, B. A., & Gladyshev, V. N. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.007 · Cited by 715 · see citing works

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Tuo, Q.-Z., Lei, P., Jackman, K. A., Li, X.-L., Xiong, H., Li, X.-L., Liuyang, Z.-Y., Roisman, L. C., Zhang, S.-T., Ayton, S., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.171 · Cited by 708 · see citing works

The interplay between cell signalling and the mevalonate pathway in cancer

Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 697 · see citing works

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

Do Van, B., Gouel, F., Jonneaux, A., Timmerman, K., Gelé, P., Pétrault, M., Bastide, M., Laloux, C., Moreau, C., Bordet, R., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.011 · Cited by 689 · see citing works

Inhibition of neuronal ferroptosis protects hemorrhagic brain

Li, Q., Han, X., Lan, X., Gao, Y., Wan, J., Durham, F., Cheng, T., Yang, J., Wang, Z., Jiang, C. Q., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90777 · Cited by 686 · see citing works

The release and activity of HMGB1 in ferroptosis

Wen, Q., Liu, J., Kang, R., Zhou, B., & Tang, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.090 · Cited by 683 · see citing works

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · cited 2× · see citing works

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Zhou, B., Zhang, J.-Y., Liu, X.-S., Chen, H., Ai, Y.-L., Cheng, K., Sun, R.-Y., Zhou, D., Han, J., & Wu, Q. (2018) · Cell Research · doi:10.1038/s41422-018-0090-y · Cited by 663 · see citing works

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

Roh, J.-L., Kim, E. H., Jang, H., & Shin, D. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.010 · Cited by 662 · see citing works

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Kapralov, A. A., Yang, Q., Dar, H. H., Tyurina, Y. Y., Anthonymuthu, T. S., Kim, R., Croix, C. M. S., Mikulska‐Ruminska, K., Liu, B., Shrivastava, I. H., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-019-0462-8 · Cited by 657 · see citing works

Characterization of ferroptosis in murine models of hemochromatosis

Wang, H., An, P., Xie, E., Wu, Q., Fang, X., Gao, H., Zhang, Z., Li, Y., Wang, X., Zhang, J., et al. (2017) · Hepatology · doi:10.1002/hep.29117 · Cited by 656 · see citing works

Effect of Lipid Peroxidation on the Properties of Lipid Bilayers: A Molecular Dynamics Study

Wong-ekkabut, J., Xu, Z., Triampo, W., Tang, I., Tieleman, D. P., & Monticelli, L. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.112565 · Cited by 645 · see citing works

Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc− cystine transporter: a new action for an old drug

Gout, P., Buckley, A., Simms, C., & Bruchovsky, N. (2001) · Leukemia · doi:10.1038/sj.leu.2402238 · Cited by 640 · see citing works

Iron Homeostasis

Andrews, N. C., & Schmidt, P. J. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.164337 · Cited by 640 · see citing works

Ironing out Ferroportin

Drakesmith, H., Nemeth, E., & Ganz, T. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.006 · Cited by 638 · see citing works

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

Shen, Z., Liu, T., Li, Y., Lau, J., Yáng, Z., Fan, W., Zhou, Z., Shi, C., Ke, C., Bregadze, V. I., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b06201 · Cited by 636 · see citing works

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

Efferth, T. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.02.009 · Cited by 632 · see citing works

Mammalian lipoxygenases and their biological relevance

Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 629 · see citing works

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., et al. (2014) · JAMA · doi:10.1001/jama.2013.282834 · Cited by 628 · see citing works

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

Ma, S., Henson, E. S., Chen, Y., & Gibson, S. B. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.208 · Cited by 627 · see citing works

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Hassannia, B., Wiernicki, B., Ingold, I., Qu, F., Herck, S. V., Tyurina, Y. Y., Bayır, H., Abhari, B. A., Angeli, J. P. F., Choi, S. M., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99032 · Cited by 626 · see citing works

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

Devos, D., Moreau, C., Devedjian, J. C., Kluza, J., Pétrault, M., Laloux, C., Jonneaux, A., Ryckewaert, G., Garçon, G., Rouaix, N., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5593 · Cited by 622 · see citing works

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., Conrad, M., Turker, M. Z., Gao, M., Jiang, X., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.164 · Cited by 622 · see citing works

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

Kang, R., Zeng, L., Zhu, S., Xie, Y., Liu, J., Wen, Q., Cao, L., Xie, M., Ran, Q., Kroemer, G., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.009 · Cited by 620 · see citing works

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Mai, T. T., Hamaï, A., Hienzsch, A., Cañeque, T., Müller, S., Wicinski, J., Cabaud, O., Leroy, C., David, A., Acevedo, V., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2778 · Cited by 612 · see citing works

Iron‐dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

Louandre, C., Ezzoukhry, Z., Godin, C., Barbare, J., Mazière, J., Chauffert, B., & Galmiche, A. (2013) · International Journal of Cancer · doi:10.1002/ijc.28159 · Cited by 602 · see citing works

Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila

Berry, D. L., & Baehrecke, E. H. (2007) · Cell · doi:10.1016/j.cell.2007.10.048 · Cited by 602 · see citing works

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Lei, P., Ayton, S., Finkelstein, D. I., Spoerri, L., Ciccotosto, G. D., Wright, D. K., Wong, B. X. W., Adlard, P. A., Cherny, R. A., Lam, L. Q., et al. (2012) · Nature Medicine · doi:10.1038/nm.2613 · Cited by 594 · see citing works

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

Brown, C. W., Amante, J. J., Chhoy, P., Elaimy, A. L., Liu, H., Zhu, L. J., Baer, C. E., Dixon, S. J., & Mercurio, A. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.10.007 · Cited by 582 · see citing works

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

Belaidi, A. A., & Bush, A. I. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13425 · Cited by 580 · see citing works

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

Yoshida, M., Minagawa, S., Araya, J., Sakamoto, T., Hara, H., Tsubouchi, K., Hosaka, Y., Ichikawa, A., Saito, N., Kadota, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10991-7 · Cited by 572 · see citing works

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells

Basit, F., van Oppen, L. M. P. E., Schöckel, L., Bossenbroek, H. M., Vries, S. E. V. E., Hermeling, J. C., Grefte, S., Kopitz, C., Héroult, M., Willems, P. H. G. M., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.133 · Cited by 570 · see citing works

The Biological Synthesis of Cholesterol

Bloch, K. (1965) · Science · doi:10.1126/science.150.3692.19 · Cited by 562 · see citing works

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

Chang, L., Chiang, S.-K., Chen, S., Yu, Y., Chou, R., & Chang, W. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.12.025 · Cited by 561 · see citing works

Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression

Sasaki, H., Sato, H., Kuriyama-Matsumura, K., Sato, K., Maebara, K., Wang, H., Tamba, M., Itoh, K., Yamamoto, M. P., & Bannai, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208704200 · Cited by 544 · see citing works

Molecular oxygen: Friend and foe*The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury

HESS, M., & Manson, N. H. (1984) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(84)80011-5 · Cited by 542 · see citing works

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

Cramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4232 · Cited by 541 · see citing works

Oxytosis: a novel form of programmed cell death

Shirlee Tan, B. S. P., David Schubert, B. S. P., & Pamela Maher, B. S. P. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013394741 · Cited by 522 · see citing works

Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration

Janssen, C. I. F., & Kiliaan, A. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.10.002 · Cited by 515 · see citing works

Free radical-lipid interactions and their pathological consequences

Rice-Evans, C. A., & Burdon, R. H. (1993) · Progress in Lipid Research · doi:10.1016/0163-7827(93)90006-i · Cited by 514 · see citing works

Lipid storage and lipophagy regulates ferroptosis

Bai, Y., Meng, L., Han, L., Jia, Y., Zhao, Y., Gao, H., Kang, R., Wang, X., Tang, D., & Dai, E. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.039 · Cited by 510 · see citing works

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

Eaton, J. K., Furst, L., Ruberto, R. A., Moosmayer, D., Hilpmann, A., Ryan, M. J., Zimmermann, K. C., Cai, L. L., Niehues, M., Badock, V., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0501-5 · Cited by 510 · see citing works

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

Li, Y., Maher, P., & Schubert, D. (1997) · Neuron · doi:10.1016/s0896-6273(00)80953-8 · Cited by 509 · see citing works

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

Miziorko, H. M. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.09.028 · Cited by 509 · see citing works

The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11

Liu, T., Jiang, L., Tavana, O., & Gu, W. J. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3037 · Cited by 494 · see citing works

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., Alehagen, U., Steurer, G., & Littarru, G. P. (2014) · JACC: Heart Failure · doi:10.1016/j.jchf.2014.06.008 · Cited by 488 · see citing works

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

Du, J., Wang, T., Li, Y., Zhou, Y., Wang, X., Yu, X., Ren, X., An, Y., Wu, Y., Sun, W., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.011 · Cited by 487 · see citing works

Iron and ferroptosis: A still ill‐defined liaison

Doll, S. G., & Conrad, M. (2017) · IUBMB Life · doi:10.1002/iub.1616 · Cited by 472 · see citing works

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

Hayano, M., Yang, W., Corn, C. K., Pagano, N. C., & Stockwell, B. R. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.93 · Cited by 462 · see citing works

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.

Bannai, S., & Kitamura, E. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85901-x · Cited by 456 · see citing works

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

Lee, Y., Lee, D.-H., Choudry, H. A., Bartlett, D. L., & Lee, Y. J. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0055 · Cited by 434 · see citing works

Polyunsaturated fatty acids, part 1: Occurrence, biological activities and applications

Gill, I., & Valivety, R. H. (1997) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01076-7 · Cited by 431 · see citing works

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

Soares, R. O. D. S., Losada, D. M., Jordani, M. C., Évora, P. R. B., & Castro-e-Silva, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205034 · Cited by 415 · see citing works

Neurodegenerative diseases

Heemels, M.-T. (2016) · Nature · doi:10.1038/539179a · Cited by 406 · see citing works

Leigh Syndrome with Nephropathy and CoQ10 Deficiency Due to decaprenyl diphosphate synthase subunit 2 (PDSS2) Mutations

López, L. C., Schuelke, M., Quinzii, C. M., Kanki, T., Rodenburg, R. J., Naini, A., DiMauro, S., & Hirano, M. (2006) · The American Journal of Human Genetics · doi:10.1086/510023 · Cited by 397 · see citing works

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

Ooko, E., Saeed, M. E. M., Kadioglu, O., Sarvi, S., Colak, M., Elmasaoudi, K., Janah, R., Greten, H. J., & Efferth, T. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.08.002 · Cited by 387 · see citing works

Interaction of tumor cells and lymphatic vessels in cancer progression

Alitalo, A. K., & Detmar, M. J. (2011) · Oncogene · doi:10.1038/onc.2011.602 · Cited by 385 · see citing works

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

Martín‐Bastida, A., Ward, R. J., Newbould, R. D., Piccini, P. P., Sharp, D. J., Kabba, C., Patel, M. C., Spino, M., Connelly, J., Tricta, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01402-2 · Cited by 382 · see citing works

Novel Action of Paclitaxel against Cancer Cells: Bystander Effect Mediated by Reactive Oxygen Species

Alexandre, J., Hu, Y., Lu, W., Pelicano, H., & Huang, P. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3914 · Cited by 380 · see citing works

Beneficial role of Nrf2 in regulating NADPH generation and consumption

Wu, K. C., Cui, J. Y., & Klaassen, C. D. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr183 · Cited by 368 · see citing works

BID links ferroptosis to mitochondrial cell death pathways

Neitemeier, S., Jelinek, A., Laino, V., Hoffmann, L., Eisenbach, I., Eying, R., Ganjam, G. K., Dolga, A. M., Oppermann, S., & Culmsee, C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.007 · Cited by 366 · see citing works

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

Hishikawa, D., Shindou, H., Kobayashi, S., Nakanishi, H., Taguchi, R., & Shimizu, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712245105 · Cited by 365 · see citing works

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

Kong, Z., Liu, R., & Cheng, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.030 · Cited by 364 · see citing works

Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

Müller, T., Dewitz, C., Schmitz, J., Schröder, A. S., Bräsen, J. H., Stockwell, B. R., Murphy, J. M., Kunzendorf, U., & Krautwald, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2547-4 · Cited by 362 · see citing works

Mutant p53 as a target for cancer treatment

Duffy, M. J., Synnott, N. C., & Crown, J. P. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.06.023 · Cited by 361 · see citing works

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

Jelinek, A., Heyder, L., Daude, M., Plessner, M., Krippner, S., Grosse, R., Diederich, W. E., & Culmsee, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.019 · Cited by 359 · see citing works

Elucidating Compound Mechanism of Action by Network Perturbation Analysis

Woo, J. H., Shimoni, Y., Yang, W. S., Subramaniam, P., Iyer, A., Nicoletti, P., Rodríguez Martínez, M., López, G., Mattioli, M., Realubit, R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.056 · Cited by 351 · see citing works

A Mutation in Para-Hydroxybenzoate-Polyprenyl Transferase (COQ2) Causes Primary Coenzyme Q10 Deficiency

Quinzii, C. M., Naini, A., Salviati, L., Trevisson, E., Navas, P., DiMauro, S., & Hirano, M. (2006) · The American Journal of Human Genetics · doi:10.1086/500092 · Cited by 348 · see citing works

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

Singh, N. K., & Rao, G. N. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.11.001 · Cited by 348 · see citing works

Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene ( Trsp )

Bösl, M. R., Takaku, K., Oshima, M., Nishimura, S., & Taketo, M. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5531 · Cited by 337 · see citing works

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

Schneider, M., Förster, H., Boersma, A., Seiler, A., Wehnes, H., Sinowatz, F., Neumüller, C., Deutsch, M. J., Walch, A. K., de Angelis, M. H., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-132795 · Cited by 328 · see citing works

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

He, Y., Liu, X., Xing, L., Wan, X., Chang, X. Y., & Jiang, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119911 · Cited by 320 · see citing works

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

Rong, X., Albert, C. J., Hong, C., Duerr, M. A., Chamberlain, B. T., Tarling, E. J., Ito, A., Gao, J., Wang, B., Edwards, P. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.002 · Cited by 316 · see citing works

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Carlson, B. A., Tobe, R., Yefremova, E., Tsuji, P. A., Hoffmann, V. J., Schweizer, U., Gladyshev, V. N., Hatfield, D. L., & Conrad, M. (2016) · Redox Biology · doi:10.1016/j.redox.2016.05.003 · Cited by 316 · see citing works

Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

Xu, T., Ma, Y., Yuan, Q., Hu, H., Hu, X., Qian, Z., Rolle, J. K., Gu, Y., & Li, S. (2020) · ACS Nano · doi:10.1021/acsnano.9b09426 · Cited by 316 · see citing works

The Golgi apparatus: 100 years of progress and controversy

Farquhar, M. G., & Palade, G. E. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01187-2 · Cited by 312 · see citing works

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 309 · see citing works

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

Zhang, Y., Wang, D., Xu, S., Zhang, S., Fan, Y., Yang, Y., Guo, S., Wang, S., Guo, T., Wang, Z., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.11.001 · Cited by 307 · see citing works

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury*

Kenny, E., Fidan, E., Yang, Q., Anthonymuthu, T. S., New, L. A., Meyer, E. A., Wang, H., Kochanek, P. M., Dixon, C. E., Kagan, V. E., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003555 · Cited by 305 · see citing works

Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity

Shimada, K., Hayano, M., Pagano, N. C., & Stockwell, B. R. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2015.11.016 · Cited by 300 · see citing works

Recent progress in treatment of hepatocellular carcinoma.

Chen, Z., Xie, H., Hu, M., Huang, T., Hu, Y., Sang, N., & Zhao, Y. (2020) · PubMed Central · Cited by 298 · see citing works

Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity

Ramanathan, B., Jan, K.-Y., Chen, C., Hour, T., Yu, H., & Pu, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1162 · Cited by 287 · see citing works

Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.

Mãrtensson, J., Meister, A., & M�rtensson, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4656 · Cited by 287 · see citing works

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

Jiang, T., Chen, N., Zhao, F., Wang, X.-J., Kong, B., Zheng, W., & Zhang, D. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0713 · Cited by 286 · see citing works

Glutathione peroxidase 4: a new player in neurodegeneration?

Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 281 · see citing works

Ubiquinol: an endogenous antioxidant in aerobic organisms

Ernster, L., & Forsmark-Andr�e, P. (1993) · Journal of Molecular Medicine · doi:10.1007/bf00226842 · Cited by 280 · see citing works

System xc− and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

Mandal, P. K., Seiler, A., Perisic, T., Kölle, P., Banjac Canak, A., Förster, H., Weiss, N., Kremmer, E., Lieberman, M. W., Bannai, S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.121327 · Cited by 269 · see citing works

An Endoperoxide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells

Aron, A. T., Loehr, M. O., Bogena, J., & Chang, C. J. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08016 · Cited by 269 · see citing works

Mechanism of Free Radical Oxygenation of Polyunsaturated Fatty Acids by Cyclooxygenases

Rouzer, C. A., & Marnett, L. J. (2003) · Chemical Reviews · doi:10.1021/cr000068x · Cited by 266 · see citing works

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

Kim, E. H., Shin, D., Lee, J., Jung, A. R., & Roh, J. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.06.018 · Cited by 261 · see citing works

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

Cao, J., Chen, X., Li, J., Lu, B., Meng, Y. G., Zhu, D., Zhu, H., He, Q., Yang, B., & Ying, M. (2020) · Nature Communications · doi:10.1038/s41467-020-15109-y · Cited by 258 · see citing works

Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders

Mollet, J., Giurgea, I., Schlemmer, D., Dallner, G., Chrétien, D., Delahodde, A., Bacq, D., de Lonlay, P., Münnich, A., & Rötig, A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29089 · Cited by 254 · see citing works

Ceria Nanoparticles Meet Hepatic Ischemia‐Reperfusion Injury: The Perfect Imperfection

Ni, D., Wei, H., Chen, W., Bao, Q., Rosenkrans, Z. T., Barnhart, T. E., Ferreira, C. A., Wang, Y., Yao, H., Sun, T., et al. (2019) · Advanced Materials · doi:10.1002/adma.201902956 · Cited by 252 · see citing works

Baicalein and 12/15-Lipoxygenase in the Ischemic Brain

van Leyen, K., Kim, H. Y., Lee, S., Jin, G., Arai, K., & Lo, E. H. (2006) · Stroke · doi:10.1161/01.str.0000249004.25444.a5 · Cited by 251 · see citing works

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

Dar, H. H., Tyurina, Y. Y., Mikulska-Ruminska, K., Shrivastava, I., Ting, H.-C., Tyurin, V. A., Krieger, J., St. Croix, C. M., Watkins, S., Bayir, E., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99490 · Cited by 251 · see citing works

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

Yoo, S.-E., Chen, L., Na, R., Liu, Y., Rios, C. I., Remmen, H. V., Richardson, A. G., & Ran, Q. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.043 · Cited by 250 · see citing works

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

Guan, X., Li, X., Yang, X., Yan, J., Shi, P., Ba, L., Cao, Y., & Wang, P. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116795 · Cited by 250 · see citing works

Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming

Wan, C., Sun, Y., Tian, Y., Lu, L., Dai, X., Meng, J., Huang, J., He, Q., Wu, B., Zhang, Z., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay9789 · Cited by 248 · see citing works

AMID, an Apoptosis-inducing Factor-homologous Mitochondrion-associated Protein, Induces Caspase-independent Apoptosis

Wu, M., Xu, L., Li, X., Zhai, Z., & Shu, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202285200 · Cited by 241 · see citing works

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 235 · see citing works

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Llabani, E., Hicklin, R. W., Lee, H. Y., Motika, S. E., Crawford, L. A., Weerapana, E., & Hergenrother, P. J. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0261-6 · Cited by 234 · see citing works

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

Krainz, T., Gaschler, M. M., Lim, C., Sacher, J. R., Stockwell, B. R., & Wipf, P. (2016) · ACS Central Science · doi:10.1021/acscentsci.6b00199 · Cited by 233 · see citing works

Cellular iron: Ferroportin is the only way out

Ganz, T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.005 · Cited by 232 · see citing works

BAY 87‐2243, a highly potent and selective inhibitor of hypoxia‐induced gene activation has antitumor activities by inhibition of mitochondrial complex I

Ellinghaus, P., Heisler, I., Unterschemmann, K., Haerter, M., Beck, H., Greschat, S., Ehrmann, A., Summer, H., Flamme, I., Oehme, F., et al. (2013) · Cancer Medicine · doi:10.1002/cam4.112 · Cited by 230 · see citing works

Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases

Zhou, Z., & Tan, E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0218-4 · Cited by 229 · see citing works

Protective role of melatonin in cardiac ischemia‐reperfusion injury: From pathogenesis to targeted therapy

Zhou, H., Ma, Q., Zhu, P., Ren, J. T., Reiter, R. J., & Chen, Y. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12471 · Cited by 228 · see citing works

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

Hanson, L. R., Roeytenberg, A., Martinez, P. M., Coppes, V. G., Sweet, D. C., Rao, R. J., Marti, D. L., Hoekman, J., Matthews, R. B., Frey, W. H., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.149807 · Cited by 224 · see citing works

LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis

Li, C., Dong, X., Du, W., Shi, X. G., Chen, K., Zhang, W., & Gao, M. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00297-2 · Cited by 222 · see citing works

Targeting p53 pathways: mechanisms, structures, and advances in therapy

Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works

Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery

Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works

Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects

Tong, B., Ba, Y., Li, Z., Yang, C., Su, K., Qi, H., Zhang, D., Liu, X., Wu, Y., Chen, Y., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106505 · Cited by 117 · see citing works

Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations

Greenough, M. A., Lane, D. J. R., Balez, R., Anastacio, H. T. D., Zeng, Z., Ganio, K., McDevitt, C. A., Acevedo, K., Belaidi, A. A., Koistinaho, J., et al. (2022) · Cell Death & Differentiation · doi:10.1038/s41418-022-01003-1 · Cited by 102 · see citing works

Effective integration of multi-omics with prior knowledge to identify biomarkers via explainable graph neural networks

Tripathy, R. K., Frohock, Z., Wang, H., Cary, G. A., Keegan, S., Carter, G. W., & Li, Y. (2025) · npj Systems Biology and Applications · doi:10.1038/s41540-025-00519-9 · Cited by 36 · see citing works

Navigating the complexities of cell death: Insights into accidental and programmed cell death

Lotfi, M.-S., & Rassouli, F. B. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102586 · Cited by 15 · see citing works

Chelation protocols for the elimination and prevention of iron overload in thalassaemia

Kontoghiorghes, G. J. (2017) · Frontiers in bioscience · doi:10.2741/4634 · Cited by 13 · see citing works

Comparison of the Effects of Deferiprone versus Deferoxamine on Growth and Virulence of <i>Yersinia enterocolitica</i>

Lesic, B., Foulon, J., & Carniel, E. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1741-1745.2002 · Cited by 65 · see citing works

Pharmacotherapy of iron overload in thalassaemic patients

Ceci, A., Felisi, M., Sanctis, V. D., et al. (2003) · Expert Opinion on Pharmacotherapy · doi:10.1517/eoph.4.10.1763.22324 · Cited by 1 · see citing works

A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia.

Galanello, R., Kattamis, A., Piga, A. G., et al. (2006) · PubMed · Cited by 80 · see citing works

Effective new treatments of iron overload in thalassaemia using the ICOC combination therapy protocol of deferiprone (L1) and deferoxamine and of new chelating drugs.

Kontoghiorghes, G. J., & Kolnagou, A. (2006) · PubMed · Cited by 9 · see citing works