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Survival of adult neurons lacking cholesterol synthesis in vivo

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RSH/Smith–Lemli–Opitz Syndrome: A Multiple Congenital Anomaly/Mental Retardation Syndrome due to an Inborn Error of Cholesterol Biosynthesis

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3β-Hydroxysterol Δ7-reductase and the Smith–Lemli–Opitz syndrome

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DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model

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Cholesterol--Making or Breaking the Synapse

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Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells

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Cholesterol-mediated Neurite Outgrowth Is Differently Regulated between Cortical and Hippocampal Neurons

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Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population

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Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy

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Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series

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The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts

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Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells

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A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome

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Expression and p75 neurotrophin receptor dependence of cholesterol synthetic enzymes in adult mouse brain

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The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain

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Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis

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Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

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Disentangling the genetic overlap between cholesterol and suicide risk

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Desmosterolosis and desmosterol homeostasis in the developing mouse brain

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PACAP signaling to DREAM: A cAMP-Dependent Pathway that Regulates Cortical Astrogliogenesis

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Vulnerability of DHCR7+/− mutation carriers to aripiprazole and trazodone exposure

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Novel cell separation method for molecular analysis of neuron-astrocyte co-cultures

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Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

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Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases

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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

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Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association

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Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders

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Connecting the Dots Between Hypercholesterolemia and Alzheimer’s Disease: A Potential Mechanism Based on 27-Hydroxycholesterol

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Central nervous system cholesterol metabolism in health and disease

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Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease

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MeCP2 Is an Epigenetic Factor That Links DNA Methylation with Brain Metabolism

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TrkB transmembrane domain: bridging structural understanding with therapeutic strategy

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Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?

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Medication effects on developmental sterol biosynthesis

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Brain cholesterol homeostasis and its association with neurodegenerative diseases

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Cholesterol in the CNS: functions, recycling and remyelination

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Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block

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LXR agonism for CNS diseases: promises and challenges

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Transcriptome analysis of human induced excitatory neurons supports a strong effect of clozapine on cholesterol biosynthesis

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Neural Metabolic Networks: Key Elements of Healthy Brain Function

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Role of the Endoplasmic Reticulum in Synaptic Transmission

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Targeting of Mevalonate-Isoprenoid Pathway in Acute Myeloid Leukemia Cells by Bisphosphonate Drugs

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Balancing cholesterol in the brain: from synthesis to disposal

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Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

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Cholesterol Metabolism in Neurodegenerative Diseases

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Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health

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Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24

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Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism

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Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus

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The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

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Vitamin D, a Secosteroid Hormone and Its Multifunctional Receptor, Vitamin D Receptor, in Alzheimer’s Type Neurodegeneration

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Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology

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Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets

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How Neuromembrane Lipids Modulate Membrane Proteins: Insights from G-Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs)Preprint

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Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk

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Astrocyte‐specific loss of lactoferrin influences neuronal structure and function by interfering with cholesterol synthesis

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Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants

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Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma

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Quantitative and carbon isotope ratio analysis of fatty acids isolated from human brain hemispheres

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Lovastatin Differentially Regulates α7 and α4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons

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Optimized culture of retinal ganglion cells and amacrine cells from adult mice

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Prenylation Defects and Oxidative Stress Trigger the Main Consequences of Neuroinflammation Linked to Mevalonate Pathway Deregulation

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

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Deep transcriptome profiling reveals limited conservation of A-to-I RNA editing in Xenopus

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Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Niemann-Pick Type C1

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Enhancing 7-dehydrocholesterol suppresses brain ferroptosis and tissue injury after neonatal hypoxia–ischemia

Genaro‐Mattos, T. C., Korade, Ž., Sahar, N.-E., Angeli, J. P. F., Mirnics, K., & Peeples, E. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-58579-6 · Cited by 13 · see citing works

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone

Cenik, B., Palka, J. M., Thompson, B. M., McDonald, J. G., Tamminga, C. A., Cenik, C., & Brown, E. S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01903-3 · Cited by 12 · see citing works

Effects of food-borne cholesterol supplementation on lead-induced neurodevelopmental impairments of rats based on BDNF signaling pathway and cholesterol metabolism

Wang, S., Lu, A.-X., Li, W.-H., Zhang, H., Hu, C., Liu, J., Pan, H., Wu, M., Xu, X., Yan, C., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115026 · Cited by 11 · see citing works

Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma

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Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing glutamate/calcium and ER-mitochondria signaling

Xu, S., Cui, J.-H., Liu, X., Pang, Z., Bai, C., Jiang, C., Luan, C., Li, Y., Zhao, Y., You, Y., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.284 · Cited by 11 · see citing works

Role of cholesterol in modulating brain hyperexcitability

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Lipolysis-Stimulated Lipoprotein Receptor Acts as Sensor to Regulate ApoE Release in Astrocytes

Herzine, A., Sekkat, G., Kaminski, S., Calcagno, G., Boschi‐Müller, S., Safi, H., Corbier, C., Visvikis‐Siest, S., Claudepierre, T., & Yen, F. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158630 · Cited by 11 · see citing works

Labelfree mapping and profiling of altered lipid homeostasis in the rat hippocampus after traumatic stress: Role of oxidative homeostasis

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The low-density lipoprotein receptor-related protein-1 (LRP1) in Schwann cells controls mitochondria homeostasis in peripheral nerves

Martellucci, S., Heredia, M., Wang, Z., Whisenant, T. C., Strickland, D. K., Sánchez, R. G., Arai, T., Zhang, M., Wang, H., Gong, Z., et al. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102796 · Cited by 10 · see citing works

Cholesterol metabolism and brain injury in neonatal encephalopathy

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An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Talvio, K., Wagner, V. A., Minkeviciene, R., Kirkwood, J. S., Kulinich, A. O., Umemori, J., Bhatia, A., Hur, M., Käkelä, R., Ethell, I. M., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05147-9 · Cited by 8 · see citing works

Spatially heterogeneous lipid dysregulation in tuberculous meningitis

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Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice

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TGF-β1 suppresses de novo cholesterol biosynthesis in granulosa-lutein cells by down-regulating DHCR24 expression via the GSK-3β/EZH2/H3K27me3 signaling pathway

Li, H., Shen, J., Ma, S., Zhao, F., Zhao, W., Chen, F., Fu, Y., Li, B., Cheng, J., & Deng, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.196 · Cited by 8 · see citing works

7-ketocholesterol as a critical oxysterol: Impact on human health and safety in food systems

Kumar, S. S., Prakash, A., Keerthana, P. V., & John, M. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106856 · Cited by 7 · see citing works

DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling

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Astrocytic functions and lipid metabolism: Correlations and therapeutic targets in Alzheimer's disease and glioblastoma

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Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity

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Epoxiconazole altered hepatic metabolism in adult zebrafish based on transcriptomic analysis

Weng, Y. Z., Gu, W., & Jin, Y. (2024) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2024.109901 · Cited by 6 · see citing works

Astrocyte-Neuron Metabolic Synergies in Neurological Homeostasis and Disease

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PCSK9 Regulation of Lipid Metabolism in the Nervous System: Implications for Schwann Cell Function and Peripheral Neuropathy

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Regulation of sterol metabolism by gut microbiota and its relevance to disease

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Sex Differences in the Association Between LDL/HDL with Cognitive Decline in Older Adults: National Health and Nutrition Examination Survey

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Therapeutic Potential of Simvastatin: Cellular Mechanism, Binding Energetics, and Resistance Developments

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Fundamental origins of neural tube defects with a basis in genetics and nutrition

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Exploring Recent Developments in the Manifestation, Diagnosis, and Treatment of Patients with Smith–Lemli–Opitz Syndrome: From Molecular Pathways to Clinical Innovations

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Sex-dependent effect of sublethal copper concentrations on de novo cholesterol synthesis in astrocytes and their possible links to variations in cholesterol and amyloid precursor protein levels in neuronal membranes

Zubillaga, M., Tau, J., Rosa, D., Bellini, M., & Arnal, N. (2024) · Biology of Sex Differences · doi:10.1186/s13293-023-00578-9 · Cited by 4 · see citing works

Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease

Staurenghi, E., Testa, G., Leoni, V., Cecci, R., Floro, L., Giannelli, S., Barone, E., Marzia Perluigi, A., Leonarduzzi, G., Sottero, B., et al. (2024) · Antioxidants · doi:10.3390/antiox13040435 · Cited by 4 · see citing works

Pulsed electromagnetic stimulation promotes neuronal maturation by up-regulating cholesterol biosynthesis

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Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient

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Special characteristics of human astrocytes and their roles in brain homeostasis

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Split GFP-based fluorescent biosensors detect ER–Golgi membrane contact dynamics

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Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models

Korade, Ž., Anderson, A. C., Balog, M., Tallman, K. A., Porter, N. A., & Mirnics, K. (2025) · Biomolecules · doi:10.3390/biom15040562 · Cited by 3 · see citing works

Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem

Chen, Q., Li, L., Xu, L., Yang, B., Huang, Y., Qiao, D., & Yue, X. (2023) · International Journal of Legal Medicine · doi:10.1007/s00414-023-03039-5 · Cited by 3 · see citing works

Regulation of CNS Lipids by Protease Activated Receptor 1

Yoon, H., Triplet, E. M., Wurtz, L. I., Simon, W. L., Choi, C., & Scarisbrick, I. A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70047 · Cited by 2 · see citing works

Fetal Fentanyl Syndrome – Only the “tip of the iceberg”?

Mirnics, K. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.10.011 · Cited by 2 · see citing works

Identification of novel nutrient sensitive human yolk sac functions required for embryogenesis

White, M., Arif‐Pardy, J., Bloise, E., & Connor, K. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-81061-2 · Cited by 2 · see citing works

Cardiovascular disease and its association with insulin resistance and cholesterol

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Astrocyte, Lipid Metabolism in Alzheimer’s Disease and Glioblastoma

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Global cell-state and gene-program representations reveal conserved and context-specific perturbation responses of cellsPreprint

Pan, X., Saunders, R. A., Replogle, J. M., Weissman, J. S., & Zhuang, X. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.16.725005 · Cited by 2 · see citing works

Identifying biomarkers of hepatic fatty acid metabolism disorder in sevoflurane-induced brain developmental injury by bioinformatics analysis

Yuan, H., Lv, Y., Fan, P., Jia, P., Wang, K., Hu, K. R., Sun, H., Chen, X., & Zhang, P. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1369365 · Cited by 1 · see citing works

Deficiency of Toll-like receptor 2 is a driver of sex-related compositional and structural rearrangements of membrane lipids

Ică, R., Mlinac, K., Stojanović, M., Biricioiu, M. R., Puljko, B., Hrvat, N. M., Radmilović, M. D., Korade, Ž., Mirnics, K., Clemmer, D. E., et al. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01766-x · Cited by 1 · see citing works

DHCR24 in cholesterol metabolism and diseases of the nervous system

Zhu, H. G., Li, S., Yang, Y. Z., 张似青, Wang, Y., & Xiong, T. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02954-x · Cited by 1 · see citing works

Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances

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Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives

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Activity-dependent astrocytic cholesterol release fine-tunes modes of synaptic exo- and endocytosis

Myeong, J., & Klyachko, V. A. (2026) · The Journal of Cell Biology · doi:10.1083/jcb.202512026 · Cited by 1 · see citing works

Lipid Metabolism in Neurocognitive Disorders: Current Update

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Evaluation of Hippocampal Allostatic Load-Associated Factors in Animal Models of Post-Traumatic Stress Disorder: Relevance to Human PTSD

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Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing ER-mitochondria signalingPreprint

Xu, S., Pang, Z.-Q., Bai, C., Jia, M.-Y., Cui, J.-H., Wang, Z.-J., Liang, X.-T., & Guo, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1558216/v1

Neurology

Hoffmann, M. W., Cywes, R., Childers, A. M., Kossoff, M. M., Kossoff, E. H., Perlmutter, D., Phillips, M. C. L., Edes, G., Berger, A., Stanton, A. A., et al. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00006-1

Sterol Biomarker Discovery In Neurodegenerative Diseases

Pacciarini, M. (2023) · doi:10.23889/suthesis.65375

Oxisteróis e sua relação com a neuroinflamação na esclerose lateral amiotrófica

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PINK1 regulates cholesterol homeostasis via SCAP phosphorylation in human dopaminergic neuronsPreprint

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Staufen2 modulates the temporal dynamics of human neurogenesis in vitroPreprint

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Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth

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