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Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions
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In the citing paper
“Tau phase separation can also be induced by a coacervation mechanism, whereby oppositely charged between tau and RNA spontaneously organize into higher order biomolecular condensates.13,14”
From A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau (2026) · cites this paper as [13]
In the citing paper
“TDP-43 and tau interaction promotes their co-condensation but also suppress tau fibril formation and seeding.10,13”
From A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau (2026) · cites this paper as [13]
In the citing paper
“On the other hand, studies have suggested that phase separation prevents the formation of oligomeric toxic tau species.”
From A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau (2026) · cites this paper as [13]
In the citing paper
“Notably, high concentrations of RNA do not induce Tau LLPS but can trigger Tau aggregation (Kampers et al, 1996) without the formation of liquid‐condensed intermediates (Lin et al, 2020).”
From Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates (2022) · cites this paper as Lin et al, 2020
In the citing paper
“In the case of Tau, polyanionic RNA (or heparin; Lin et al, 2020) co‐condensate with the positively charged Tau microtubule‐assembly domain into liquid‐like droplets (Zhang et al, 2017; Lin et al, 2019).”
From Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates (2022) · cites this paper as Lin et al, 2020
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Cites
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Hernández-Vega, A., Braun, M., Scharrel, L., Jahnel, M., Wegmann, S., Hyman, B. T., Alberti, S., Diez, S., & Hyman, A. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.042 · Cited by 395
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Acetylation Disfavors Tau Phase Separation
Ferreon, J. C., Jain, A., Choi, K.-J., Tsoi, P. S., MacKenzie, K. R., Jung, S. Y., & Ferreon, A. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051360 · Cited by 183
Cofactors are essential constituents of stable and seeding-active tau fibrils
Fichou, Y., Lin, Y., Rauch, J. N., Vigers, M., Zeng, Z., Srivastava, M., Keller, T. J., Freed, J. H., Kosik, K. S., & Han, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810058115 · Cited by 128
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Cited by
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
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Ainani, H., Bouchmaa, N., Ben Mrid, R., & El Fatimy, R. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106011 · Cited by 54
Liquid-liquid phase separation in Alzheimer’s disease
Fu, Q., Zhang, B., Chen, X., & Chu, L. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02407-3 · Cited by 33
Liquid − liquid phase separation of tau: Driving forces, regulation, and biological implications
Li, P., Chen, J., Wang, X., Su, Z., Gao, M., & Huang, Y. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106167 · Cited by 30
Metadata
- Authors
- Lin, Y., Fichou, Y., Zeng, Z., Hu, N. Y., & Han, S.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-01-23
- Volume
- 11
- Issue
- 4
- Pages
- 615-627
- ISSN
- 1948-7193
- Cited by
- 107
- References
- 10
- Language
- en
- Licence
- Funders
- National Institute on Aging (R01AG056058)
- Rainwater Charitable Foundation
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- CoChat. (2026). Citation check: Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions. https://app.cochat.ai/papers/10.1021/acschemneuro.9b00627
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- Lin, Y., Fichou, Y., Zeng, Z., Hu, N. Y., & Han, S. (2020). Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.9b00627
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