High Intensity Focused Ultrasound-Responsive and Ultrastable Cerasomal Perfluorocarbon Nanodroplets for Alleviating Tumor Multidrug Resistance and Epithelial–Mesenchymal Transition
Abstract
Hypoxia is a hostile hallmark of most solid tumors, which often leads to multidrug resistance (MDR) and causes the failure of chemotherapy. Hypoxia also promotes epithelial–mesenchymal transition (EMT), leading to acceleration of tumor metastasis. Many chemotherapeutic drugs can further exacerbate hypoxia and thus promote metastasis. Therefore, relieving hypoxia is necessary for chemotherapy to inhibit both MDR and EMT. Herein, highly stable cerasomal perfluorocarbon nanodroplets with an atomic layer of polyorganosiloxane surface and pH-sensitive tumor-targeting peptide (D-vPCs-O2) were fabricated to co-deliver oxygen and therapeutic drug, doxorubicin. High-intensity focused ultrasound (HIFU) was utilized to trigger the co-release of doxorubicin and oxygen and simultaneously enhance ultrasound imaging, therefore achieving imaging-guided drug delivery. Mild-temperature HIFU (M-HIFU) not only triggered oxygen release from nanodroplets but also slightly elevated tumor temperature to accelerate tumor blood flow. The oxygen release and temperature elevation jointly relieved tumor hypoxia and alleviated MDR, which greatly enhanced the drug therapeutic efficacy as compared to clinically used doxorubicin and Doxil. Overall side effects were also largely reduced owing to the ultrastable drug loading of cerasome. The improvement of insufficient chemotherapy and the relief of tumor hypoxia corporately down-regulated TGF-β1, leading to the alleviation of EMT, and therefore significantly inhibited tumor metastasis. When “D-vPCs-O2 + M-HIFU” was utilized as a neoadjuvant chemotherapy, nanodroplets down-regulated heat shock proteins, reducing tumor relapse after the high-temperature HIFU (H-HIFU)-mediated hyperthermia ablation. The chemo-hyperthermia therapy totally eradicated tumors without any relapse or metastasis, providing a promising way to treat the triple-negative breast cancer, which is highly malignant, easily metastatic, and lacks effective treatments.
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Several studies on the remission of hypoxic tumors in combination with various chemotherapeutic agents have shown increased mean survival time and/or decreased tumor growth/metastasis.
“Several studies on the remission of hypoxic tumors in combination with various chemotherapeutic agents have shown increased mean survival time and/or decreased tumor growth/metastasis. 391 , 392”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [392]
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Hypoxia — a key regulatory factor in tumour growth
Harris, A. L. (2002) · Nature Reviews Cancer · doi:10.1038/nrc704 · Cited by 5,177 · see citing works
Biomarkers for epithelial-mesenchymal transitions
Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299 · see citing works
Tumor metastasis: mechanistic insights and clinical challenges
Steeg, P. S. (2006) · Nature Medicine · doi:10.1038/nm1469 · Cited by 2,135 · see citing works
Hyperthermia in combined treatment of cancer
Wust, P., Hildebrandt, B., Sreenivasa, G., Rau, B., Gellermann, J., Riess, H. B., FELIX, R., & Schlag, P. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00818-5 · Cited by 2,002 · see citing works
Yang, G., Xu, L., Chao, Y., Xu, J., Sun, X., Wu, Y., Peng, R., & Liu, Z. (2017) · Nature Communications · doi:10.1038/s41467-017-01050-0 · Cited by 1,491 · see citing works
Rankin, E. B., & Giaccia, A. J. (2016) · Science · doi:10.1126/science.aaf4405 · Cited by 1,340 · see citing works
High-intensity focused ultrasound in the treatment of solid tumours
Kennedy, J. E. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1591 · Cited by 1,289 · see citing works
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941 · see citing works
Gao, M., Liang, C., Song, X., Chen, Q., Jin, Q., Wang, C., & Liu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201701429 · Cited by 592 · see citing works
Song, G., Liang, C., Yi, X., Zhao, Q., Cheng, L., Yang, K., & Liu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201504617 · Cited by 587 · see citing works
Song, X., Feng, L., Liang, C., Yang, K., & Liu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02365 · Cited by 581 · see citing works
Schutt, E. G., Klein, D. H., Mattrey, R., & Riess, J. G. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200550 · Cited by 546 · see citing works
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models
Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S. J., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0256-3 · Cited by 533 · see citing works
Cancer Cell Membrane‐Biomimetic Oxygen Nanocarrier for Breaking Hypoxia‐Induced Chemoresistance
Tian, H., Luo, Z., Liu, L., Zheng, M., Chen, Z., Ma, A.-Q., Liang, R., Han, Z., Lu, C., & Cai, L. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703197 · Cited by 244 · see citing works
Surgical issues in patients with breast cancer receiving neoadjuvant chemotherapy
King, T. A., & Morrow, M. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.63 · Cited by 225 · see citing works
Tao, D., Feng, L., Chao, Y., Liang, C., Song, X., Wang, H., Yang, K., & Liu, Z. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804901 · Cited by 206 · see citing works
Conjugation of Porphyrin to Nanohybrid Cerasomes for Photodynamic Diagnosis and Therapy of Cancer
Liang, X., Li, X., Yue, X., & Dai, Z. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103557 · Cited by 164 · see citing works
Self-citationLiang, X., Gao, J., Jiang, L., Luo, J., Jing, L., Li, X., Jin, Y., & Dai, Z. (2015) · ACS Nano · doi:10.1021/nn507482w · Cited by 156 · see citing works
Self-citationMa, M., Xu, H., Chen, H., Jia, X., Zhang, K., Wang, Q., Zheng, S.-G., WU, R. T., Yao, M., Cai, X., et al. (2014) · Advanced Materials · doi:10.1002/adma.201402969 · Cited by 150 · see citing works
Self-citationHijnen, N. M., Langereis, S., & Grüll, H. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.006 · Cited by 111 · see citing works
Cheng, C., Chen, W., Zhang, L., Wu, H. H., & Zink, J. I. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b07591 · Cited by 101 · see citing works
Pusztai, L., Foldi, J., Dhawan, A., DiGiovanna, M. P., & Mamounas, E. P. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30158-5 · Cited by 83 · see citing works
Demoin, D. W., Wyatt, L. C., Edwards, K. J., Abdel-Atti, D., Sarparanta, M. P., Pourat, J., Longo, V. A., Carlin, S. D., Engelman, D. M., Andreev, O. A., et al. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00306 · Cited by 65 · see citing works
Co-delivery nanoparticle to overcome metastasis promoted by insufficient chemotherapy
Zhou, Q., Li, Y., Zhu, Y., Yu, C., Jia, H., Bao, B., Hu, H., Xiao, C., Zhang, J., Zeng, X., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.026 · Cited by 62 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Smart drug delivery systems for precise cancer therapy
Wang, X., Li, C., Wang, Y., Chen, H., Zhang, X., Luo, C., Zhou, W., Li, L., Teng, L., Yu, H., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.08.013 · Cited by 238 · see citing works
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications
Huang, H. F., Zheng, Y., Chang, M., Song, J., Xia, L., Wu, C., Jia, W., Ren, H., Feng, W., & Chen, Y. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00009 · Cited by 186 · see citing works
Nanomedicine‐Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy
Song, X., Zhang, Q., Chang, M., Ding, L., Huang, H., Feng, W. J., Xu, T., & Chen, Y. (2023) · Advanced Materials · doi:10.1002/adma.202212259 · Cited by 183 · see citing works
Non‐Invasive Thermal Therapy for Tissue Engineering and Regenerative Medicine
Li, L., Zhang, X., Zhou, J. M., Zhang, L., Xue, J., & Tao, W. (2022) · Small · doi:10.1002/smll.202107705 · Cited by 127 · see citing works
Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy
Zhang, S., Li, Z., Wang, Q., Liu, Q., Yuan, W., Feng, W., & Li, F. (2022) · Advanced Materials · doi:10.1002/adma.202201978 · Cited by 119 · see citing works
Therapeutic oxygen delivery by perfluorocarbon-based colloids
Krafft, M. P., & Riess, J. G. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102407 · Cited by 119 · see citing works
Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles
Kashapov, R. R., Ibragimova, A. R., Pavlov, R. V., Gabdrakhmanov, D. R., Kashapova, N. E., Burilova, E. A., Zakharova, L. Y., & Sinyashin, O. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137055 · Cited by 113 · see citing works
Tang, Q., Sun, S., Wang, P., Sun, L., Wang, Y., Zhang, L., Xu, M., Chen, J., Wu, R., Zhang, J., et al. (2023) · Advanced Materials · doi:10.1002/adma.202300964 · Cited by 108 · see citing works
Self-citationZeng, S., Chen, J., Gao, R., Chen, R., Xue, Q., Ren, Y., Liu, L., Tang, C., Hu, H., Zeng, N., et al. (2023) · Advanced Materials · doi:10.1002/adma.202308780 · Cited by 103 · see citing works
Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment
Pan, Y., Liu, L., Mou, X., & Cai, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c07763 · Cited by 98 · see citing works
Functional Immune Cell‐Derived Exosomes Engineered for the Trilogy of Radiotherapy Sensitization
Ma, X., Yao, M., Gao, Y., Yue, Y., Li, Y., Zhang, T., Nie, G., Zhao, X., & Liang, X. (2022) · Advanced Science · doi:10.1002/advs.202106031 · Cited by 82 · see citing works
Self-citationEngineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments
Wang, W., Zheng, H., Jiang, J., Li, Z., Jiang, D., Shi, X., Wang, H., Jiang, J., Xie, Q., Gao, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32066-w · Cited by 81 · see citing works
Yu, W., Hu, C., & Gao, H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113909 · Cited by 80 · see citing works
Recent advances in anti-multidrug resistance for nano-drug delivery system
Wang, C., Li, F., Zhang, T., Min, Y., & Sun, Y. Y. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2079771 · Cited by 75 · see citing works
MoS2 nanoflower-mediated enhanced intratumoral penetration and piezoelectric catalytic therapy
He, Y., Xu, Z., He, Y., Cao, G., Ni, S., Tang, Y., Wang, J., Yuan, Y., Ma, Z., Wang, D., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121816 · Cited by 60 · see citing works
Tang, R., He, H., Lin, X., Wu, N., Wan, L., Chen, Q., Hu, Y., Chen, C., Cao, Y., Guo, X., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006226 · Cited by 60 · see citing works
Ultrasound combined with nanomaterials for cancer therapy
Zhu, Y., Liu, Y., Khan, K., Arkin, G., Tareen, A. K., Xie, Z., He, T., Su, L., Guo, F., Lai, X., et al. (2022) · Materials Today Advances · doi:10.1016/j.mtadv.2022.100330 · Cited by 46 · see citing works
Tumor microenvironment-regulating nanomedicine design to fight multi-drug resistant tumors.
Xu, Q.-Q., Lan, X., Lin, H.-W., Xi, Q., Wang, M., Quan, X.-L., Yao, G.-Y., Yu, Z.-Q., Wang, Y.-X., & Yu, M. (2022) · Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1842 · Cited by 36 · see citing works
Recent Advances in Perfluorocarbon-Based Delivery Systems for Cancer Theranostics
Yang, Y., Liu, Y., & Jiang, Y. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00116 · Cited by 43 · see citing works
Feng, Y., Liao, Z., Zhang, H., Xie, X., You, F., Liao, X., Wu, C., Zhang, W., Yang, H., & Liu, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139506 · Cited by 41 · see citing works
Multifunctional theranostic nanomedicines for cancer treatment: Recent progress and challenges
Karthikeyan, L., Sobhana, S., Yasothamani, V., Gowsalya, K., & Vivek, R. (2023) · Biomedical Engineering Advances · doi:10.1016/j.bea.2023.100082 · Cited by 40 · see citing works
Yu, Q., Li, J., Yu, Y., Yan, M., Xu, D., & Yin, S. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216056 · Cited by 41 · see citing works
Yao, X., Lu, S., Feng, C., Suo, R., Li, H., Zhang, Y., Chen, Q., Lü, J., Wu, B., & Guo, J. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121801 · Cited by 39 · see citing works
Ultrasound-induced biophysical effects in controlled drug delivery
Zhang, L., Lin, Z., Zeng, L., Zhang, F., Sun, L., Sun, S., Wang, P., Xu, M., Zhang, J., Liang, X., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-1971-x · Cited by 41 · see citing works
Self-citationUltrasound-Induced Piezocatalysis Triggered NO Generation for Enhanced Hypoxic Tumor Therapy
Chen, J., Tang, Q., Wang, Y., Xu, M., Sun, S., Zhang, J., Wu, R., Yue, X., Li, X., Chen, Q., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c00603 · Cited by 38 · see citing works
Self-citationStimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer
Xu, L., Wu, J., Liu, Y., Lin, N., Hu, J., & Zhang, B. (2022) · Molecules · doi:10.3390/molecules27030948 · Cited by 38 · see citing works
Ding, L., Tang, S., Tang, W., Mosley, D. D., Yu, A., Sil, D., Romanova, S., Bailey, K. L., Knoell, D. L., Wyatt, T. A., et al. (2022) · Advanced Science · doi:10.1002/advs.202103676 · Cited by 36 · see citing works
Tang, C., Li, H., Sha, M., Song, J., Bai, X., Liu, K., Liu, Y., Yuan, B., Yan, J., Chang, J. K., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146054 · Cited by 37 · see citing works
Genetically Engineered Bacterial Protein Nanoparticles for Targeted Cancer Therapy
Yang, H., Jiang, F., Ji, X., Wang, L., Wang, Y., Zhang, L., Tang, Y., Wang, D., Luo, Y., Li, N., et al. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s292432 · Cited by 37 · see citing works
Ultrasound-augmented anti-inflammatory exosomes for targeted therapy in rheumatoid arthritis
Tang, Y., Wu, Z., Guo, R., Huang, J., Rong, X., Zhu, B., Wang, L., Ma, L., Cheng, C., & Qiu, L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01219g · Cited by 37 · see citing works
Recent Advances in Nanoplatform Construction Strategy for Alleviating Tumor Hypoxia
Shen, J., Chen, G., Zhao, L., Huang, G., Liu, H., Liu, B., Miao, Y., & Li, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300089 · Cited by 35 · see citing works
Fe-doped carbon dots: a novel biocompatible nanoplatform for multi-level cancer therapy
Yang, M., Li, H., Liu, X., Huang, L., Zhang, B., Liu, K., Xie, W., Jing, C., Li, D., Lu, L., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02194-6 · Cited by 35 · see citing works
Li, Q., Zhang, J., Li, J., Ye, H., Li, M., Hou, W., Li, H., & Wang, Z. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c07494 · Cited by 35 · see citing works
Ultrasound-Based Drug Delivery System
Ren, W., Xu, S., Sun, L., & Zhang, K. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210617103905 · Cited by 33 · see citing works
Wu, M., Chen, T., Wang, L., Akakuru, O. U., Ma, X., Xu, J., Hu, J., Chen, J., Fang, Q., Wu, A., et al. (2022) · Nanoscale · doi:10.1039/d2nr00985d · Cited by 32 · see citing works
Self-citationThe advance of ultrasound-enabled diagnostics and therapeutics
Han, B., Liu, Y., Zhou, Q., Yu, Y., Liu, X., Guo, Y., Zheng, X., Zhou, M., Yu, H., & Wang, W. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.039 · Cited by 31 · see citing works
Zakharova, L. Y., Maganova, F., Sinyashin, K. O., Gaynanova, G. A., Mirgorodskaya, A. B., Vasilieva, E. A., & Sinyashin, O. G. (2023) · Russian Journal of General Chemistry · doi:10.1134/s1070363223070253 · Cited by 28 · see citing works
Tao, C., Miao, X., Yan, J., Xiao, X., Wu, R., Cao, Q., Wang, Z., Lv, R., Ge, T., & Liu, J. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.08.044 · Cited by 27 · see citing works
Wu, R., Wang, Y., Sun, S., Tang, Q., Zhang, J., Chen, C., Xu, S., Ma, X., & Liang, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150134 · Cited by 26 · see citing works
Self-citationZhang, S., Yang, N., Sun, S., Zhao, H., Wang, W., Nie, J., Pei, Z., He, W., Zhang, L., Cheng, L., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.017 · Cited by 25 · see citing works
Research Progress in Oxygen Carrier Design and Application
Ye, Q., Zheng, D., Chen, K., & Wu, J. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00289 · Cited by 25 · see citing works
Liu, W.-S., Chen, Z., Lu, Z., Dong, J., Wu, J.-H., Gao, J., Deng, D., & Li, M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.001 · Cited by 25 · see citing works
Application of high intensity focused ultrasound combined with nanomaterials in anti-tumor therapy
Zhang, X., He, N., Zhang, L., Dai, T., Sun, Z., Shi, Y., Li, S., & Yu, N. (2024) · Drug Delivery · doi:10.1080/10717544.2024.2342844 · Cited by 24 · see citing works
Huang, J., Xiao, Z., Lin, M., Zhong, H., & Shuai, X. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102102 · Cited by 23 · see citing works
Gao, J., Luan, T., Lv, J., Yang, M., Li, H., & Yuan, Z. (2023) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2023.112666 · Cited by 21 · see citing works
Sun, T., Li, J., Zhou, Y., Zeng, C., Luo, C., Luo, X., & Li, H. (2023) · Small · doi:10.1002/smll.202306338 · Cited by 20 · see citing works
Cai, W., Wu, Q., Yan, Z. Z., He, W., Zhou, X., Zhou, L., Zhang, J., & Zhang, X. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.775274 · Cited by 19 · see citing works
Huang, S., Guo, W., An, J., Zhang, J., Dong, F., Wang, D., Feng, F., & Zhang, J. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c02580 · Cited by 18 · see citing works
Lin, H., Xu, Q., Zhang, F., Wu, H., Hu, B., Chen, G., Ban, X., Duan, X., & Yu, M. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145555 · Cited by 18 · see citing works
Ultrasound-responsive microparticles from droplet microfluidics
Huang, D., Wang, J., Che, J., Wen, B., & Kong, W. (2022) · Biomedical Technology · doi:10.1016/j.bmt.2022.10.001 · Cited by 17 · see citing works
High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming
Li, X., Wu, J., Xu, R., Qin, X., Wang, S., Yang, W., & Pang, Z. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.006 · Cited by 15 · see citing works
Self-citationWei, G., Gao, S., Hao, Y., Li, Z., Hu, H., Wu, H., Hu, C., Cheng, X., Zhao, W., Kong, Y., et al. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107524 · Cited by 15 · see citing works
Liu, D., Ling, Y., Liu, W., Deng, J., & Guo, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03959-x · Cited by 16 · see citing works
Wang, R., Yao, Y., Gao, Y., Liu, M., Yu, Q., Song, X., Han, X., Niu, D., & Jiang, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s391382 · Cited by 15 · see citing works
Self-citationAn on‐Demand Oxygen Nano‐vehicle Sensitizing Protein and Nucleic Acid Drug Augment Immunotherapy
Zhang, S., Wang, X., Chen, X., Shu, D., Lin, Q., Zou, H., Dong, J., Wang, B., Tang, Q., Li, H., et al. (2025) · Advanced Materials · doi:10.1002/adma.202409378 · Cited by 15 · see citing works
Li, J., Guo, L., Cai, W., Mei, J., Liu, J., & Liu, Y. (2026) · Drug Delivery · doi:10.1080/10717544.2026.2645830 · Cited by 14 · see citing works
Jin, Q., Chen, D., Song, Y., Liu, T., Li, W., Chen, Y., Qin, X., Zhang, L., Wang, J., & Xie, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041155 · Cited by 14 · see citing works
Embracing Remote Fields as the Fourth Dimension of Tissue Biofabrication
Anand, S., Müller, C., Jensen, B. N., & Chen, M. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401654 · Cited by 14 · see citing works
The Formation of Morphologically Stable Lipid Nanocarriers for Glioma Therapy
Pavlov, R. V., Romanova, E., Kuznetsov, D. M., Lyubina, A. P., Amerhanova, S. K., Voloshina, A. D., Buzyurova, D. N., Babaev, V. M., Zueva, I. V., Petrov, K. A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043632 · Cited by 14 · see citing works
Recent Advancements in Ultrasound Contrast Agents Based on Nanomaterials for Imaging
Su, Y., Huang, L., Zhang, D., Zeng, Z., Hong, S., & Lin, X. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00890 · Cited by 13 · see citing works
Progress in application of nanomedicines for enhancing cancer sono-immunotherapy
Zhao, H., Du, F., Xiang, X., Tang, Y., Feng, Z., Wang, Z., Rong, X., & Qiu, L. (2024) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2024.107105 · Cited by 13 · see citing works
Cheng, X., Shi, S., Wu, Y. P., Zhu, L., Xu, J., Hu, T., Wei, B., & Tang, R. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c01662 · Cited by 13 · see citing works
Emerging diagnostic and therapeutic technologies based on ultrasound-triggered biomaterials
Huang, D., Wang, J., Wen, B., & Zhao, Y. (2023) · Materials Futures · doi:10.1088/2752-5724/acdf05 · Cited by 12 · see citing works
Dong, T., Jiang, J., Zhang, H., Liu, H., Zou, X., Niu, J., Mao, Y., Zhu, M., Chen, X., Li, Z., et al. (2021) · Nano Convergence · doi:10.1186/s40580-021-00279-2 · Cited by 12 · see citing works
Unlocking the potential of transdermal drug delivery
Li, S., Wu, J., Peng, X., & Feng, X. (2024) · International Journal of Smart and Nano Materials · doi:10.1080/19475411.2024.2366210 · Cited by 11 · see citing works
Wei, Z., Yu, X., Huang, M., Wen, L., & Lu, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051456 · Cited by 10 · see citing works
Nanotherapeutic strategies exploiting biological traits of cancer stem cells
Wang, H., Zhang, W., Sun, Y., Xu, X., Chen, X., Zhao, K., Yang, Z., & Liu, H. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.03.016 · Cited by 10 · see citing works
Role of nanomedicines in lung cancer treatment and diagnosis: opportunities and challenges
Shah, K. A., Razzaq, A., Ali, T., Ullah, S., You, B., Iqbal, H., & Cui, J.-H. (2025) · Medical Oncology · doi:10.1007/s12032-025-02862-7 · Cited by 9 · see citing works
Xie, Y., Jiang, T., Wang, J., Qian, Y., Xu, W., Zhao, G., Gao, H., & Li, C. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202506126 · Cited by 9 · see citing works
Oxygen-Abundant and pH/NIR Dual-Responsive Nanocarriers for Tumor Hypoxia Reduction Therapy
Zhuang, J., Zhang, W., Xuan, Q., Ma, T., Zhang, Q., Chen, C., & Wang, P. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c01588 · Cited by 9 · see citing works
Dual mode imaging guided multi-functional bio-targeted oxygen production probes for tumor therapy
Wang, Y., Zhang, Z., Ren, L. M., Luo, Y., Wang, Q., & Zou, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01901-7 · Cited by 9 · see citing works
Controllable formation of bulk perfluorohexane nanodroplets by solvent exchange
Ji, Y., Zheng, J., Geng, Z., Tan, T., Hu, J., Zhang, L., & Zhang, Y. (2021) · Soft Matter · doi:10.1039/d1sm01457a · Cited by 8 · see citing works
Qiao, B., Song, X., Zhang, W., Xu, M. T., Zhuang, B., Li, W., Guo, H., Wu, W., Huang, G., Zhang, M., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01707-z · Cited by 8 · see citing works
Liang, Y., Wang, P., Li, Y., Liu, Z.-Y., Wang, R., Sun, G., Sun, H., & Xie, S.-Y. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122488 · Cited by 8 · see citing works
Meng, D., Guo, L., Shi, D., Sun, X. Y., Shang, M., Xiao, S., Zhou, X., Zhao, Y., Wang, X., & Li, J. (2023) · Cancer Nanotechnology · doi:10.1186/s12645-023-00172-z · Cited by 8 · see citing works
Sun, S., Wu, R., Ma, S. S., Cao, Z., Luo, L., Sun, S., Cui, L., & Liang, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161398 · Cited by 7 · see citing works
Self-citationZhang, M., Xu, P., Xu, H., Ren, K., Tang, H., Wang, S., Luo, J., Xie, J., & Li, J. (2025) · Materials Today · doi:10.1016/j.mattod.2025.11.025 · Cited by 7 · see citing works
Nanomaterials for the Diagnosis and Treatment of Triple‐Negative Breast Cancer
Sun, X., Li, D., Lv, Y., Zhang, M., Qiao, D., Zhang, Z., Ren, H., Zhang, Y., Yang, Z., & Gao, J. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.2019 · Cited by 7 · see citing works
Wang, T., Wu, Q., Zhu, C., Zhang, Z., Gu, Y., Chang, Z., Xiao, L., Jia, R., Yin, B., Sun, L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c08379 · Cited by 6 · see citing works
Liquid-gas phase-change nanoplatforms for ultrasound-mediated cancer theranostics
Lei, J., Lin, J., & Huang, P. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107719 · Cited by 5 · see citing works
Chen, T., Xu, S., Huang, W., & Yan, D. (2022) · Biomaterials Science · doi:10.1039/d2bm00739h · Cited by 5 · see citing works
Mitochondria-targeted nanocarriers for smart response delivery of natural products: a review
Cao, J., Lu, W., Lv, Y. L., Li, M., Tang, Y. H., & Feng, Y. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2025.2611940 · Cited by 4 · see citing works
Zhao, K., Wu, H., Yang, W., Cheng, Y., Wang, S., Jiang, A.-N., Yan, K., & Goldberg, S. N. (2022) · Nanoscale · doi:10.1039/d1nr08125j · Cited by 4 · see citing works
Advancing disease theranostics with ultrasound: Sono-physics, sono -chemistry, and sono-biology
Zhang, J., Li, X., Ma, Y., Yu, X., Yuan, L., Jia, S., Teng, Y., Liu, X., & Shi, Z. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100313 · Cited by 3 · see citing works
Self-citationYang, D., Sun, C., He, Y., Wu, R., Li, C., Gong, X., Zhuang, H., Wang, Y., Qin, H., Wang, Y., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c21141 · Cited by 3 · see citing works
Self-citationOxygen/siRNA-carrying fluoro-nanosensitizers for radio-immunotherapy sensitization
Wu, F., Qian, Y., Ge, C., Zhou, Y., Yan, J., Li, X., Liu, X., Lei, Y., Zhao, Z., Wei, Y., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.011 · Cited by 3 · see citing works
Self-citationTherapeutic Applications of Nanodroplets in Ultrasound: In Vitro and in Vivo Perspectives
Wang, L., Liu, Z., Lai, Y., Tao, W., Zhou, X., & Yuan, L. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c07130 · Cited by 2 · see citing works
Shi, Z., Si, X., Wan, R.-M., Zhu, Z.-Y., Song, W., & Chen, X. (2025) · Chinese Journal of Polymer Science · doi:10.1007/s10118-025-3397-4 · Cited by 2 · see citing works
Wang, W., Qiu, T., Ding, X., He, D.-L., Yuan, Y.-B., Jiang, M.-K., Long, X., Gao, J., Yin, M.-M., Wang, T., et al. (2025) · Applied Materials Today · doi:10.1016/j.apmt.2025.102623 · Cited by 2 · see citing works
Jiang, A., Wang, T., Lü, X., Tian, Y., Jiang, Z., Xu, B., Zhang, H., & Fang, W. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad1dfe · Cited by 2 · see citing works
Gong, T., Zhao, W. X., Chen, Y., He, Y., Xiong, J., Xiong, Y., Yin, L., Luo, Y., & Tang, Y. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03833-8 · Cited by 1 · see citing works
Xie, Y., Jiang, T., Wang, J., Qian, Y., Xu, W., Zhao, G., Gao, H., & Li, C. (2025) · Angewandte Chemie · doi:10.1002/ange.202506126 · Cited by 1 · see citing works
Qi, Y., Ren, S., Meng, L., Che, Y., & Wang, X. (2026) · Science China Materials · doi:10.1007/s40843-025-3813-y · Cited by 1 · see citing works
Preparation of Novel Bi-Modal Nano Contrast Agent and Its Application in Diagnosis of Breast Cancer
Zhang, S., Fan, M., Wang, Y., Zhan, Z., Hu, Y. C., & Yu, A. (2021) · Science of Advanced Materials · doi:10.1166/sam.2021.4061
Wang, W., Qiu, T., Ding, X., He, D., Yuan, Y., Jiang, M., Long, X., Gao, J., Yin, M.-M., Wang, T., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5055796
Wang, W., Qiu, T., Ding, X., He, D., Yuan, Y., Jiang, M., Long, X., Gao, J., Yin, M.-M., Wang, T., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5052818
Li, J., Zhang, W., Ma, H., Bukhari, S. Z., & Wang, B. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107840
Meng, D., Guo, L., Shi, D., Sun, X., Shang, M., Xiao, S., Zhou, X., Zhao, Y., Wang, X., & Li, J. (2023) · Figshare · doi:10.6084/m9.figshare.22624301
Wang, Y., Zhang, Z., Ren, L. M., Luo, Y., Wang, Q., & 邹建中 (2023) · Figshare · doi:10.6084/m9.figshare.22723006
- Authors
- Ma, X., Yao, M., Shi, J., Li, X., Gao, Y., Luo, Q., Hou, R., Liang, X., & Wang, F.
- Affiliations
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
- Corresponding author
- Liang, Xiaolong
- Wang, Fan
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-11-11
- Volume
- 14
- Issue
- 11
- Pages
- 15904-15918
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3104458648
- Cited by
- 110
- References
- 25
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 15 · 2023: 28 · 2022: 22 · 2021: 14
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2016YFA0201400, 2017YFA0205600)
- Peking University Third Hospital (BYSY2015023, BYSYZD2019018, jyzc2018-02)
- National Natural Science Foundation of China (81571810, 81630045, 81771846, 81822022, 81927802)
- Beijing Talents Foundation (2018000021223ZK48)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- high-intensity focused ultrasound, cerasomes, perfluorocarbon nanodroplets, tumor hypoxia, multidrug resistance, epithelial-mesenchymal transition, doxorubicin, oxygen delivery, ultrasound-triggered drug release, imaging-guided drug delivery, TGF-β1, metastasis, triple-negative breast cancer, neoadjuvant chemotherapy, heat shock proteins
- MeSH terms
- Doxorubicin, Fluorocarbons, Humans, Neoplasms, Drug Delivery Systems, Drug Resistance, Multiple, Cell Line, Tumor, Epithelial-Mesenchymal Transition
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