Redox-Activated Contrast-Enhanced T 1‑Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver
Abstract
Abstract GSH-mediated liver biotransformation is a crucial physiological process demanding efficient research tools. Here, we report a type of amorphous FexMnyO nanoparticles (AFMO-ZDS NPs) as redox-activated probes for in vivo visualization of the dynamics of GSH-mediated biotransformation in liver with T1-weighted magnetic resonance imaging (MRI). This imaging technique reveals the periodic variations in GSH concentration during the degradation of AFMO-ZDS NPs due to the limited transportation capacity of GSH carriers in the course of GSH efflux from hepatocytes to perisinusoidal space, providing direct imaging evidence for this important carrier-mediated process during GSH-mediated biotransformation. Therefore, this technique offers an effective method for in-depth investigations of GSH-related biological processes in liver under various conditions as well as a feasible means for the real-time assessment of liver functions, which is highly desirable for early diagnosis of liver diseases and prompt a toxicity evaluation of pharmaceuticals.
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GSH and its related enzymes form an antioxidant defense system that protects hepatocytes from oxidative stress and other potential injuries.
“GSH and its related enzymes form an antioxidant defense system that plays a key role in protecting hepatocytes from oxidative stress and other potential injuries (Liu et al., 2021).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Liu et al., 2021
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Self-citation
- Authors
- Liu, K., Kang, B., Luo, X., Yang, Z., Sun, C., Li, A., Fan, Y., Chen, X., Gao, J., & Lin, H.
- Affiliations
- Xiamen University (CN)
- National University of Singapore (SG)
- Corresponding author
- Gao, Jinhao
- Lin, Hongyu
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-11-09
- Volume
- 15
- Issue
- 11
- Pages
- 17831-17841
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3211824867
- Cited by
- 24
- References
- 51
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 2
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Fujian Province (2020J02001)
- Central University Basic Research Fund of China (20720200005)
- National Natural Science Foundation of China (21521004, 21771148, 22077107, 22125702, 92059109)
- Xiamen City (3502Z20206051)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- glutathione, liver biotransformation, T1-weighted imaging, hepatocytes, perisinusoidal space, liver function assessment, liver disease diagnosis
- MeSH terms
- Biotransformation, Glutathione, Liver, Oxidation-Reduction, Nanoparticles
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