Cited by 24Characterization and Applications of Magnetic NanoparticlesLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and Applications

Redox-Activated Contrast-Enhanced T 1‑Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver

Liu, Kun, Kang, Bilun, Luo, Xiangjie, Yang, Zhaoxuan, Sun, Chengjie, Li, Ao, Fan, Yifan, Chen, Xiaoyuan +2 more·2021·ACS Nano

Abstract

Abstract GSH-mediated liver biotransformation is a crucial physiological process demanding efficient research tools. Here, we report a type of amorphous FexMnyO nanoparticles (AFMO-ZDS NPs) as redox-activated probes for in vivo visualization of the dynamics of GSH-mediated biotransformation in liver with T1-weighted magnetic resonance imaging (MRI). This imaging technique reveals the periodic variations in GSH concentration during the degradation of AFMO-ZDS NPs due to the limited transportation capacity of GSH carriers in the course of GSH efflux from hepatocytes to perisinusoidal space, providing direct imaging evidence for this important carrier-mediated process during GSH-mediated biotransformation. Therefore, this technique offers an effective method for in-depth investigations of GSH-related biological processes in liver under various conditions as well as a feasible means for the real-time assessment of liver functions, which is highly desirable for early diagnosis of liver diseases and prompt a toxicity evaluation of pharmaceuticals.

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Crossref · 10.1021/acsnano.1c06026

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Authors
Liu, K., Kang, B., Luo, X., Yang, Z., Sun, C., Li, A., Fan, Y., Chen, X., Gao, J., & Lin, H.
Affiliations
  • Xiamen University (CN)
  • National University of Singapore (SG)
Corresponding author
  • Gao, Jinhao
  • Lin, Hongyu
Venue
ACS Nano
Published
2021-11-09
Volume
15
Issue
11
Pages
17831-17841
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W3211824867
Cited by
24
References
51
Citations by year
2026: 4 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 2
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Foundation of Fujian Province (2020J02001)
  • Central University Basic Research Fund of China (20720200005)
  • National Natural Science Foundation of China (21521004, 21771148, 22077107, 22125702, 92059109)
  • Xiamen City (3502Z20206051)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
glutathione, liver biotransformation, T1-weighted imaging, hepatocytes, perisinusoidal space, liver function assessment, liver disease diagnosis
MeSH terms
Biotransformation, Glutathione, Liver, Oxidation-Reduction, Nanoparticles

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