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Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT
Abstract
Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy of acceptor planarization and donor rotation is proposed to design type I photosensitizers (PSs) and photothermal reagents. Acceptor planarization can not only enforce intramolecular charge transfer to redshift NIR absorption but also transfer the type of PSs from type II to type I photochemical pathways. Donor rotation optimizes photothermal conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, and 2TPEVDPP, with different number of rotors were prepared. Experimental results showed that three compounds were excellent type I PSs, and the corresponding 2TPEVDPP nanoparticles (NPs) with the most rotors possessed the highest PCE. The photophysical properties of 2TPEVDPP NPs are particularly suitable for in vivo NIR fluorescence imaging-guided synergistic PDT/PTT therapy. The proposed strategy is helpful for exploiting type I phototherapeutic reagents with high efficacy for synergistic PDT and PTT.
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Metadata
- Authors
- Feng, L., Li, C., Liu, L., Wang, Z., Chen, Z., Yu, J., Ji, W., Jiang, G., Zhang, P., Wang, J., & Tang, B. Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-03-01
- Volume
- 16
- Issue
- 3
- Pages
- 4162-4174
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4214510983
- Cited by
- 268
- References
- 63
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- closed
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