CoChat
Sign Up
Cited by 31

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Multilayered Nanoarchitectonics of Poly(ethylene glycol) Nanoparticles with Tunable Stiffness Modulate Bio–Nano Interactions and Targeted Drug Delivery

Li, Mengqi, Gao, Zhiliang, Lv, Huiyuan, Sekhar, Kanaparedu P. C., Song, Aixin, Jiang, Xinyi, Hao, Jingcheng, Cui, Jiwei·2025·ACS Nano
DOI 10.1021/acsnano.5c03978
Open this paper in CoChat — free account

Abstract

Stiffness, as a crucial physicochemical property of nanoparticles (NPs), has demonstrated a significant impact on bio-nano interactions, including blood circulation, biodistribution, tumor accumulation, and cellular uptake. However, the potential role of NP stiffness in modulating bio-nano interactions to potentiate drug delivery efficacy remains largely unexplored. In this study, poly(ethylene glycol) (PEG) NPs are engineered by the sophisticated layer-by-layer (LbL) assembly approach, and the Young's moduli of NPs in the range of 2-31 kPa are tuned by control over the bilayer numbers. Notably, softer PEG NPs resulted in less adsorption of the protein corona and cell association. The half-life of blood circulation time of PEG NPs decreases along with the increase in stiffness/bilayer number of NPs, while the accumulation of PEG NPs in the liver is contrary to the case. In addition, stiffness influences the targeted drug delivery efficacy, where softer PEG NPs modified with hyaluronic acid exhibited higher cell targeting and tumor accumulation as well as better inhibition of tumor growth. This work highlights the bilayer number-mediated stiffness of NPs and the vital role of stiffness in bio-nano interactions, which provides a promising approach to design nanocarriers for improved drug delivery efficacy.

Overview

Integrity signals

Registry

Crossref · 10.1021/acsnano.5c03978

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 2 references

Research works printed but not linked: 56

  1. 10.1016/j.addr.2020.06.030 · DOI
  2. 10.1038/s44222-023-00138-1 · DOI · Paper page
  3. 10.1016/j.actbio.2023.05.043 · DOI
  4. 10.1021/jacs.4c12264 · DOI
  5. 10.1002/adma.202309355 · DOI
  6. 10.1038/s41565-020-0759-5 · DOI
  7. 10.1016/j.addr.2019.01.002 · DOI
  8. 10.1016/j.ajps.2020.07.005 · DOI
  9. 10.1021/acsnano.3c05853 · DOI
  10. 10.1021/acsnano.9b01181 · DOI
  11. 10.1002/anie.202116653 · DOI
  12. 10.1073/pnas.2104826118 · DOI
  13. 10.1016/j.jcis.2021.08.148 · DOI
  14. 10.1021/jacs.7b10694 · DOI
  15. 10.1016/j.biomaterials.2020.120323 · DOI
  16. 10.1021/acsnano.4c09838 · DOI
  17. 10.1002/adma.202110267 · DOI
  18. 10.1002/adma.201300981 · DOI
  19. 10.1002/adma.201402753 · DOI
  20. 10.1021/acsmacrolett.4c00330 · DOI
  21. 10.1002/adhm.202402954 · DOI
  22. 10.1021/jacs.2c06877 · DOI
  23. 10.1021/acsnano.2c00893 · DOI
  24. 10.1039/D3CC06098E · DOI
  25. 10.1021/acs.accounts.3c00172 · DOI
  26. 10.1021/acsnano.2c04543 · DOI
  27. 10.1021/acsnano.4c11652 · DOI
  28. 10.1038/s41577-022-00825-x · DOI · Paper page
  29. 10.1021/acsnano.1c01642 · DOI
  30. 10.1021/acsnano.4c13214 · DOI
  31. 10.1021/acsnano.0c06679 · DOI
  32. 10.1039/D2TB00672C · DOI
  33. 10.1021/acsbiomaterials.3c00481 · DOI
  34. 10.1021/acsnano.3c09273 · DOI
  35. 10.1021/acsnano.9b08714 · DOI
  36. 10.1021/nn301159a · DOI
  37. 10.1002/(SICI)1097-0320(19990701)36:3<254::AID-CYTO16>3.0.CO;2-4 · DOI
  38. 10.1016/j.ijengsci.2017.02.002 · DOI
  39. 10.1152/ajpcell.00502.2001 · DOI
  40. 10.1007/s10237-009-0156-3 · DOI
  41. 10.1038/s41592-018-0015-1 · DOI
  42. 10.1016/j.jbbm.2005.11.003 · DOI
  43. 10.1039/D3LC00363A · DOI
  44. 10.1016/j.addr.2022.114356 · DOI
  45. 10.1002/adma.201805740 · DOI
  46. 10.1002/adma.202303266 · DOI
  47. 10.1021/jacs.2c02277 · DOI
  48. 10.1021/acsnano.4c09919 · DOI
  49. 10.1021/acsnano.6b00053 · DOI
  50. 10.1038/s41467-020-16772-x · DOI
  51. 10.1002/smll.202106529 · DOI
  52. 10.1016/j.jconrel.2023.06.014 · DOI
  53. 10.1021/jacs.3c07577 · DOI
  54. 10.1038/s41565-023-01455-7 · DOI
  55. 10.1038/s41565-021-00858-8 · DOI
  56. 10.1039/C5SC00416K · DOI

Cited by

Sorted by citations

Metadata

Authors
Li, M., Gao, Z., Lv, H., Sekhar, K. P. C., Song, A., Jiang, X., Hao, J., & Cui, J.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2025-06-09
Volume
19
Issue
24
Pages
22240-22252
ISSN
  • 1936-0851
  • 1936-086X
DOI
10.1021/acsnano.5c03978
Cited by
31
References
2
Language
en
Licence
Funders
  • National Natural Science Foundation of China (22372091)
  • International Cooperation Project of Shandong Province (WST2021019)
  • Center for International Cooperation and Disciplinary Innovation (B20033)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review