The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Simultaneous Detection of Dual Prostate Specific Antigens Using Surface-Enhanced Raman Scattering-Based Immunoassay for Accurate Diagnosis of Prostate Cancer
Abstract
Accurate analysis of specific biomarkers in clinical serum is essential for early diagnosis and treatment of cancer. Here, a surface-enhanced Raman scattering (SERS)-based immunoassay, using magnetic beads and SERS nano tags, was developed for the determination of free to total (f/t) prostate specific antigen (PSA) ratio to improve the diagnostic performance of prostate cancer. To assess the clinical applicability of the proposed method, SERS-based assays for the simultaneous detection of dual PSA markers, free PSA (f-PSA) and complexed PSA (c-PSA), were performed for clinical samples in the gray zone between 4.0 and 10.0 ng/mL. Our assay results for f/t PSA ratio showed a good linear correlation with those measured using the electrochemiluminescence (ECL) system installed in the clinical laboratory of the University Hospital. In addition, the simultaneous assay provided better precision than parallel assays for the detection of f-PSA and c-PSA in 13 clinical serum samples. Therefore, our SERS-based assay for simultaneous detection of dual PSA markers in clinical fluids has strong potential for application in the accurate diagnosis of prostate cancer.
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Cited by
In Vitro and In Vivo SERS Biosensing for Disease Diagnosis
Moore, T. J., Moody, A. S., Payne, T. D., Sarabia, G. M., Daniel, A. R., & Sharma, B. (2018) · Biosensors · doi:10.3390/bios8020046 · Cited by 161
Kim, H., Park, S., Jeong, I. G., Song, S. H., Jeong, Y., Kim, C.-S., & Lee, K. H. (2021) · ACS Nano · doi:10.1021/acsnano.0c06946 · Cited by 130
Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time
Swiner, D. J., Jackson, S., Burris, B. J., & Badu-Tawiah, A. K. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04901 · Cited by 73
Metadata
- Authors
- Cheng, Z., Choi, N., Wang, R., Lee, S., Moon, K. C., Yoon, S.-Y., Chen, L., & Choo, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-04-27
- Volume
- 11
- Issue
- 5
- Pages
- 4926-4933
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2608064079
- Cited by
- 373
- References
- 17
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, Z., Choi, N., Wang, R., Lee, S., Moon, K. C., Yoon, S.-Y., Chen, L., & Choo, J. (2017). Simultaneous Detection of Dual Prostate Specific Antigens Using Surface-Enhanced Raman Scattering-Based Immunoassay for Accurate Diagnosis of Prostate Cancer. ACS Nano. https://doi.org/10.1021/acsnano.7b01536
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