The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fabrication of SERS-fluorescence dual modal nanoprobes and application to multiplex cancer cell imaging
Abstract
We report a highly sensitive optical imaging technology using surface-enhanced Raman scattering (SERS)-fluorescence dual modal nanoprobes (DMNPs). Fluorescence microscopy is a well-known imaging technique that shows specific protein distributions within cells. However, most currently available fluorescent organic dyes have relatively weak emission intensities and are rapidly photo-bleached. Thus more sensitive and stable probes are needed. In this work we develop DMNPs, which can be used for both SERS and fluorescence detection. SERS detection is a powerful technique that allows ultrasensitive chemical or biochemical analysis through unlimited multiplexing and single molecule sensitivity. Combining advantages of fluorescence and SERS allows these dual modal nanostructures to be used as powerful probes for novel biomedical imaging. In this work, the fabrication and characterization of the SERS-fluorescence DMNPs and application to biological imaging were investigated using markers CD24 and CD44, which are co-expressed in MDA-MB-231 breast cancer cells, as a model system. SERS imaging with DMNPs was found to be a powerful tool to determine the co-localization of CD24 and CD44 in the cell.
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Cites
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cited by
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Cheng, Z., Choi, N., Wang, R., Lee, S., Moon, K. C., Yoon, S.-Y., Chen, L., & Choo, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b01536 · Cited by 373
Self-citationNgo, H. T., Gandra, N., Fales, A. M., Taylor, S. M., & Vo-Dinh, T. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.01.073 · Cited by 135
Wang, Y. W., Kang, S., Khan, A., Bao, P. Q., & Liu, J. T. C. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.003714 · Cited by 110
Rapid ratiometric biomarker detection with topically applied SERS nanoparticles
Wang, Y. "., Khan, A., Som, M., Wang, D., Chen, Y., Leigh, S. Y., Meza, D., McVeigh, P. Z., Wilson, B. C., & Liu, J. T. C. (2014) · TECHNOLOGY · doi:10.1142/s2339547814500125 · Cited by 74
Metadata
- Authors
- Lee, S., Chon, H., Yoon, S.-Y., Lee, E. K., Chang, S.-I., Lim, D. W., & Choo, J.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 4
- Issue
- 1
- Pages
- 124-129
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2166985514
- Cited by
- 167
- References
- 1
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, S., Chon, H., Yoon, S.-Y., Lee, E. K., Chang, S.-I., Lim, D. W., & Choo, J. (2012). Fabrication of SERS-fluorescence dual modal nanoprobes and application to multiplex cancer cell imaging. Nanoscale. https://doi.org/10.1039/c1nr11243k
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