The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Antimicrobial Gold Nanoclusters
Abstract
Bulk gold (Au) is known to be chemically inactive. However, when the size of Au nanoparticles (Au NPs) decreases to close to 1 nm or sub-nanometer dimensions, these ultrasmall Au nanoclusters (Au NCs) begin to possess interesting physical and chemical properties and likewise spawn different applications when working with bulk Au or even Au NPs. In this study, we found that it is possible to confer antimicrobial activity to Au NPs through precise control of their size down to NC dimension (typically less than 2 nm). Au NCs could kill both Gram-positive and Gram-negative bacteria. This wide-spectrum antimicrobial activity is attributed to the ultrasmall size of Au NCs, which would allow them to better interact with bacteria. The interaction between ultrasmall Au NCs and bacteria could induce a metabolic imbalance in bacterial cells after the internalization of Au NCs, leading to an increase of intracellular reactive oxygen species production that kills bacteria consequently.
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Cited by
Antimicrobial Activity of Metal and Metal‐Oxide Based Nanoparticles
Gold, K., Slay, B., Knackstedt, M., & Gaharwar, A. K. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201700033 · Cited by 758
Gong, F., Cheng, L., Yang, N., Betzer, O., Feng, L., Zhou, Q., Li, Y., Chen, R., Popovtzer, R., & Liu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201900730 · Cited by 533
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Synergistic antibacterial strategy based on photodynamic therapy: Progress and perspectives
Hu, X., Zhang, H., Wang, Y., Shiu, B.-C., Lin, J.-H., Zhang, S., Lou, C.-W., & Li, T.-T. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138129 · Cited by 365
Bimetallic Nanoparticles for Antimicrobial Applications
Arora, N., Thangavelu, K., & Karanikolos, G. N. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00412 · Cited by 268
Metadata
- Authors
- Zheng, K., Setyawati, M. I., Leong, D. T., & Xie, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-06-13
- Volume
- 11
- Issue
- 7
- Pages
- 6904-6910
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2622764259
- Cited by
- 615
- References
- 41
- FWCI
- 25.29
- Type
- journal article
- Language
- en
- Open access
- closed
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