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Cited by 192

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes

Yu, Xinhe, Gao, Duo, Gao, Liquan, Lai, Jianhao, Zhang, Chenran, Zhao, Yang, Zhong, Lijun, Jia, Bing, Wang, Fan, Chen, Xiaoyuan, Liu, Zhaofei·2017·ACS Nano
DOI 10.1021/acsnano.7b04736
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Abstract

Effective cancer therapy depends not only on destroying the primary tumor but also on conditioning the host immune system to recognize and eliminate residual tumor cells and prevent metastasis. In this study, a tumor integrin αvβ6-targeting peptide (the HK peptide)-functionalized graphene oxide (GO) was coated with a photosensitizer (HPPH). The resulting GO conjugate, GO(HPPH)-PEG-HK, was investigated whether it could destroy primary tumors and boost host antitumor immunity. We found that GO(HPPH)-PEG-HK exhibited significantly higher tumor uptake than GO(HPPH)-PEG and HPPH. Photodynamic therapy (PDT) using GO(HPPH)-PEG suppressed tumor growth in both subcutaneous and lung metastatic mouse models. Necrotic tumor cells caused by GO(HPPH)-PEG-HK PDT activated dendritic cells and significantly prevented tumor growth and lung metastasis by increasing the infiltration of cytotoxic CD8 + T lymphocytes within tumors as evidenced by in vivo optical and single-photon emission computed tomography (SPECT)/CT imaging. These results demonstrate that tumor-targeted PDT using GO(HPPH)-PEG-HK could effectively ablate primary tumors and destroy residual tumor cells, thereby preventing distant metastasis by activating host antitumor immunity and suppressing tumor relapse by stimulation of immunological memory.

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Metadata

Authors
Yu, X., Gao, D., Gao, L., Lai, J., Zhang, C., Zhao, Y., Zhong, L., Jia, B., Wang, F., Chen, X., & Liu, Z.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2017-09-18
Volume
11
Issue
10
Pages
10147-10158
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/acsnano.7b04736
OpenAlex
W2754457053
Cited by
192
References
11
FWCI
10.13
Type
journal article
Language
en
Open access
closed

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