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Biomimetic Magnetosomes as Versatile Artificial Antigen-Presenting Cells to Potentiate T-Cell-Based Anticancer Therapy
Open accessAbstract
Adoptive T-cell transfer for cancer therapy relies on both effective ex vivo T-cell expansion and in vivo targeting performance. One promising but challenging method for accomplishing this purpose is to construct multifunctional artificial antigen-presenting cells (aAPCs). We herein developed biomimetic magnetosomes as versatile aAPCs, wherein magnetic nanoclusters were coated with azide-engineered leucocyte membranes and then decorated with T-cell stimuli through copper-free click chemistry. These nano aAPCs not only exhibited high performance for antigen-specific cytotoxic T-cell (CTL) expansion and stimulation but also visually and effectively guided reinfused CTLs to tumor tissues through magnetic resonance imaging and magnetic control. The persisting T cells were able to delay tumor growth in a murine lymphoma model, while the systemic toxicity was not notable. These results together demonstrated the excellent potential of this "one-but-all" aAPC platform for T-cell-based anticancer immunotherapy.
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Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002
Cancer immunotherapy comes of age
Mellman, I., Coukos, G., & Dranoff, G. (2011) · Nature · doi:10.1038/nature10673 · Cited by 3,893
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Fang, R. H., Gao, W., & Zhang, L. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00699-x · Cited by 980
Jiang, Y., Krishnan, N., Zhou, J., Chekuri, S., Wei, X., Kroll, A. V., Yu, C. L., Duan, Y., Gao, W., Fang, R. H., et al. (2020) · Advanced Materials · doi:10.1002/adma.202001808 · Cited by 371
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Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine
Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., & Chen, C. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02277 · Cited by 284
Chiang, M.-R., Hsu, C.-W., Pan, W.-C., Tran, N.-T., Lee, Y.-S., Chiang, W.-H., Liu, Y.-C., Chen, Y.-W., Chiou, S.-H., & Hu, S.-H. (2025) · ACS Nano · doi:10.1021/acsnano.4c09525 · Cited by 174
Engineering Nano‐Therapeutics to Boost Adoptive Cell Therapy for Cancer Treatment
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Metadata
- Authors
- Zhang, Q., Wei, W., Wang, P., Zuo, L., Li, F., Xu, J., Xi, X., Gao, X., Ma, G., & Xie, H.-Y.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-20
- Volume
- 11
- Issue
- 11
- Pages
- 10724-10732
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2754964600
- Cited by
- 210
- References
- 2
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
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