On the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA

Kulkarni, Jayesh A., Darjuan, Maria M., Mercer, Joanne E., Chen, Sam, van der Meel, Roy, Thewalt, Jenifer L., Tam, Yuen Yi C., Cullis, Pieter R.·2018·ACS Nano

Cited by (662)

Items 201–300 of 662

  1. Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin
    Juliana Bolsoni, Danny X. Liu, Fatemeh Mohabatpour, Ronja Ebner, Gaurav Sadhnani, Belal Tafech, Jerry Leung, Selina Rahman Shanta, Kevin An, Tessa Morin et al. · 2023 · ACS Nano
  2. Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use
    Kent T. J. Chen, Malathi Anantha, Ada W.Y. Leung, Jayesh A. Kulkarni, Gardênia Carmen Gadelha Militão, Mohamed Wehbe, Brent W. Sutherland, Pieter R. Cullis, Marcel B. Bally · 2019 · Drug Delivery and Translational Research
  3. A robust post-insertion method for the preparation of targeted siRNA LNPs
    Laura E. Swart, Arnold C. Koekman, Cor W. Seinen, Hasan Issa, Milad Rasouli, Raymond Michel Schiffelers, Olaf T Heidenreich · 2022 · International Journal of Pharmaceutics
  4. Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids
    Juncheng Lu, Elena N. Atochina‐Vasserman, Devendra S. Maurya, Muhammad Irhash Shalihin, Dapeng Zhang, Srijay S. Chenna, Jasper Adamson, Matthew Liu, Habib Ur Rehman Shah, Honey Shah et al. · 2023 · Pharmaceutics
  5. A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles
    Valentina Francia, Yao Zhang, Miffy H. Y. Cheng, Raymond Michel Schiffelers, Dominik Witzigmann, Pieter R. Cullis · 2024 · Proceedings of the National Academy of Sciences
  6. High-throughput platforms for machine learning-guided lipid nanoparticle design
    Andrew R. Hanna, David Issadore, Michael J. Mitchell · 2025 · Nature Reviews Materials
  7. Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery
    Yusuke Hirai, Saeki Ryoko, Furan Song, Hiroyuki Koide, Fukata Naofumi, Koji Tomita, Noriyuki Maeda, Naoto Oku, Tomohiro Asai · 2020 · International Journal of Pharmaceutics
  8. Ionizable Lipid Nanoparticles for mRNA Delivery: Internal Self-Assembled Inverse Mesophase Structure and Endosomal Escape
    Haitao Yu, Brendan Dyett, Calum John Drummond, Jiali Zhai · 2025 · Accounts of Chemical Research
  9. Towards design of drugs and delivery systems with the Martini coarse-grained model
    Lisbeth R. Kjølbye, Gilberto P. Pereira, Alessio Bartocci, Martina Pannuzzo, Simone Albani, Alessandro Marchetto, Brian Jiménez‐García, Juliette Martin, Giulia Rossetti, Marco Cecchini et al. · 2022 · QRB Discovery
  10. pH‐Dependent Behavior of Ionizable Cationic Lipids in mRNA‐Carrying Lipoplexes Investigated by Molecular Dynamics Simulations
    Giovanni Settanni, Wolfgang Brill, Heinrich Haas, Friederike Schmid · 2021 · Macromolecular Rapid Communications
  11. Characterization of mRNA-LNP structural features and mechanisms for enhanced mRNA vaccine immunogenicity
    Kangzeng Wu, Fengwei Xu, Yongchao Dai, Shanshan Jin, Anjie Zheng, Ning Zhang, Yuhong Xu · 2024 · Journal of Controlled Release
  12. Rational design of lipid nanoparticles for enabling gene therapies
    Cedric A. Brimacombe, Jayesh A. Kulkarni, Miffy H. Y. Cheng, Kevin An, Dominik Witzigmann, Pieter R. Cullis · 2025 · Molecular Therapy — Methods & Clinical Development
  13. Acidic pH-induced changes in lipid nanoparticle membrane packing
    Kyoka Koitabashi, Hiroki Nagumo, Mizuka Nakao, Tomoko Machida, Kohki Yoshida, Kumiko Sakai‐Kato · 2021 · Biochimica et Biophysica Acta (BBA) - Biomembranes
  14. Lipid nanovehicles overcome barriers to systemic RNA delivery: Lipid components, fabrication methods, and rational design
    Jing Yan, Hao Zhang, Guangfeng Li, Jiacan Su, Yan Wei, Can Xu · 2023 · Acta Pharmaceutica Sinica B
  15. Lung-Specific mRNA Delivery Enabled by Sulfonium Lipid Nanoparticles
    David O. Popoola, Zhi Long Cao, Yuqin Men, Xinyuan Li, Mariano Sebastian Viapiano, Stephan Wilkens, Juntao Luo, Yong Teng, Qinghe Meng, Yamin Li · 2024 · Nano Letters
  16. Tetrahydropyrimidine Ionizable Lipids for Efficient mRNA Delivery
    Ivan Isaac, Altab Shaikh, Mayurakkhi Bhatia, Qian Liu, Seungman Park, Chandrabali Bhattacharya · 2024 · ACS Nano
  17. In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA
    Ayoub Medjmedj, Albert Ngalle Loth, Rudy Clémençon, Josef Hamáček, Chantal Pichon, Federico Perche · 2022 · Nanomaterials
  18. Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out
    Anindita De, Young Tag Ko · 2023 · Expert Opinion on Drug Delivery
  19. Development of Polymer–Lipid Hybrid Nanoparticles for Large-Sized Plasmid DNA Transfection
    Masatoshi Maeki, Shuya Uno, Kaisei Sugiura, Yusuke Sato, Yoichiro Fujioka, Akihiko Ishida, Yusuke Ohba, Hideyoshi Harashima, Manabu Tokeshi · 2023 · ACS Applied Materials & Interfaces
  20. Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations
    Anna Pratsinis, Yuchen Fan, Michaela Portmann, Michal Hammel, Ponien Kou, Apoorva Sarode, Philippe Ringler, Ľubomír Kováčik, Matthias E. Lauer, Jens Lamerz et al. · 2023 · International Journal of Pharmaceutics
  21. Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles
    Mae M. Lewis, Melissa R. Soto, Esther Y. Maier, Steven Wulfe, Sandy Bakheet, Hannah Obregon, Debadyuti Ghosh · 2023 · Bioengineering & Translational Medicine
  22. Single-Particle Spectroscopic Chromatography Reveals Heterogeneous RNA Loading and Size Correlations in Lipid Nanoparticles
    Sixuan Li, Yizong Hu, Jinghan Lin, Zachary Schneiderman, Fangchi Shao, Lai Wei, Andrew I. Li, Kuangwen Hsieh, Efrosini Kokkoli, Tine Curk et al. · 2024 · ACS Nano
  23. Effect of lipid composition on RNA-Lipid nanoparticle properties and their sensitivity to thin-film freezing and drying
    Khaled AboulFotouh, Benjamin Southard, Huy Minh Dao, Haiyue Xu, Chaeho Moon, Robert O. Williams, Zhengrong Cui · 2023 · International Journal of Pharmaceutics
  24. Quantitative Visualization of Lipid Nanoparticle Fusion as a Function of Formulation and Process Parameters
    Albert Kamanzi, Yao Zhang, Yifei Gu, Faith Liu, Romain Berti, Benjamin L. Wang, Fariba Saadati, Marco A. Ciufolini, Jayesh A. Kulkarni, Pieter R. Cullis et al. · 2024 · ACS Nano
  25. Engineering Lipid Nanoparticles for mRNA Immunotherapy
    Robby C. Zwolsman, Youssef Bahaaeldin Darwish, Ewelina Kluza, Roy van der Meel · 2025 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  26. Targeting and tracking mRNA lipid nanoparticles at the particle, transcript and protein level
    Diana D. Kang, Adam R. Marks, Judit Morlà‐Folch, Yizhou Dong, Brian D. Brown, Abraham J. P. Teunissen · 2025 · Nature Biomedical Engineering
  27. Elucidating lipid nanoparticle properties and structure through biophysical analyses
    Marshall Scott Padilla, Sarah J. Shepherd, Andrew R. Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes, Ryann A. Joseph, Hannah M. Yamagata, Adele S. Ricciardi et al. · 2025 · Nature Biotechnology
  28. Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium
    Joke Deprez, Rein Verbeke, Sofie Meulewaeter, Ilke Aernout, Heleen Dewitte, Tine Decruy, Julie Coudenys, Julie Van Duyse, Gert Van Isterdael, Dan Peer et al. · 2023 · Nature Nanotechnology
  29. DoE-derived continuous and robust process for manufacturing of pharmaceutical-grade wide-range LNPs for RNA-vaccine/drug delivery
    Kakon Nag, Md. Enamul Haq Sarker, Samir Kumar, Habiba Khan, Sourav Chakraborty, Md. Jikrul Islam, Juwel Chandra Baray, Md. Maksudur Rahman Khan, Asif Mahmud, Uttam Barman et al. · 2022 · Scientific Reports
  30. Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by 1H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties
    Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Taiki Fujimoto, Misaki Nakamura, Fumie Sakuma, Shun Kaneko, Taisei Tokumoto, Koki Nishimura, Junpei Takeda et al. · 2023 · Molecular Pharmaceutics
  31. Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments
    Adiran Garaizar, Christian David Díaz‐Oviedo, Nina Zablowsky, Sami Rissanen, Johannes Köbberling, Jiawei Sun, Christoph Steiger, Patrick Steigemann, Florian A. Mann, Katharina Meier · 2024 · Proceedings of the National Academy of Sciences
  32. Computational Methods for Modeling Lipid-Mediated Active Pharmaceutical Ingredient Delivery
    Markéta Paloncýová, Mariana Valério, Ricardo Nascimento dos Santos, Petra Kührová, Martin Šrejber, Petra Čechová, Dimitar A. Dobchev, Akshay Balsubramani, Pavel Banáš, Vikram Agarwal et al. · 2025 · Molecular Pharmaceutics
  33. Environment‐Responsive Lipid/siRNA Nanoparticles for Cancer Therapy
    Zheng‐Rong Lu, Victoria E. A. Laney, Ryan C.W. Hall, Nadia R. Ayat · 2020 · Advanced Healthcare Materials
  34. Optimizing pDNA Lipo-polyplexes: A Balancing Act between Stability and Cargo Release
    Simone Berger, Ana Krhač Levačić, Elisa Hörterer, Ulrich Wilk, Teoman Benli‐Hoppe, Yanfang Wang, Özgür Öztürk, Jie Luo, Ernst Wagner · 2021 · Biomacromolecules
  35. Formulation of Nucleic Acids by Encapsulation in Lipid Nanoparticles for Continuous Production of mRNA
    Alina Hengelbrock, A. Schmidt, Jochen Strube · 2023 · Processes
  36. mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles
    Rebecca E. McKenzie, Jordan James Minnell, Mitch Ganley, Gavin F. Painter, Sarah L. Draper · 2023 · Current Protocols
  37. ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma
    Lin Xiong, Shuang Chen, Sihui Li, Dan He, Yashi Wang, Qiang Zhang, Zhidi He, Man Li, Qin He · 2025 · Journal of Controlled Release
  38. Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide
    Dominik Witzigmann, Philipp Uhl, Sandro Sieber, Christina Kaufman, Tomaž Einfalt, Katrin Schöneweis, Philip Grossen, Jonas Buck, Yi Ni, Susanne Schenk et al. · 2019 · eLife
  39. Cyclo-RGD Truncated Polymeric Nanoconstruct with Dendrimeric Templates for Targeted HDAC4 Gene Silencing in a Diabetic Nephropathy Mouse Model
    Nidhi Raval, Hardi Jogi, Piyush Gondaliya, Kiran Kalia, Rakesh Kumar Tekade · 2020 · Molecular Pharmaceutics
  40. Innovative lipoplexes formulations with enhanced siRNA efficacy for cancer treatment: Where are we now?
    Manon Berger, Anna Lechanteur, Brigitte Évrard, Géraldine Piel · 2021 · International Journal of Pharmaceutics
  41. Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA
    Jenna L. McCann, Carmen Daniela Sosa‐Miranda, Hui‐Shan Guo, Ryan Reshke, Alexandre Savard, Adriana Zardini Buzatto, James A. Taylor, Liang Li, Derrick Gibbings · 2022 · Journal of Extracellular Vesicles
  42. One-Step Production Using a Microfluidic Device of Highly Biocompatible Size-Controlled Noncationic Exosome-like Nanoparticles for RNA Delivery
    Niko Kimura, Masatoshi Maeki, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi · 2021 · ACS Applied Bio Materials
  43. Lipid Vesicles and Other Polymolecular Aggregates—From Basic Studies of Polar Lipids to Innovative Applications
    Peter Walde, Sosaku Ichikawa · 2021 · Applied Sciences
  44. Nanoparticle Delivery Platforms for RNAi Therapeutics Targeting COVID-19 Disease in the Respiratory Tract
    Yuan Zhang, Juhura G. Almazi, Hui Xin Ong, Matt D. Johansen, Scott Ledger, Daniela Traini, Philip M. Hansbro, Anthony Dominic Kelleher, Chantelle Ahlenstiel · 2022 · International Journal of Molecular Sciences
  45. Use of a lipid nanoparticle system as a Trojan horse in delivery of gold nanoparticles to human breast cancer cells for improved outcomes in radiation therapy
    Kyle Bromma, Kristy Rieck, Jayesh A. Kulkarni, Connor O’Sullivan, Wonmo Sung, Pieter R. Cullis, Jan Schuemann, Devika Basnagge Chithrani · 2019 · Cancer Nanotechnology
  46. Zwitterionic Polymer-Decorated Lipid Nanoparticles for mRNA Delivery in Mammalian Cells
    Phim-on Khunsuk, Chitsuda Pongma, Tanapat Palaga, Voravee P. Hoven · 2023 · Biomacromolecules
  47. Lipid nanoparticles: a promising tool for nucleic acid delivery in cancer immunotherapy
    Tasneem Abaza, Eman Mohamed, Mohamed Y. Zaky · 2025 · Medical Oncology
  48. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency
    Amy W. Strilchuk, Scott C. Meixner, Jerry Leung, Nooshin Safikhan, Jayesh A. Kulkarni, Hannah Russell, Roy van der Meel, Michael R. Sutherland, Albert Phillip Owens, Joseph S. Palumbo et al. · 2020 · Blood
  49. Strategies to load therapeutics into polysaccharide-based nanogels with a focus on microfluidics: A review
    Nicole Zoratto, Elita Montanari, Marco Viola, Jia Wang, Tommasina Coviello, Chiara Di Meo, Pietro Matricardi · 2021 · Carbohydrate Polymers
  50. Impact of Lipid Tail Length on the Organ Selectivity of mRNA-Lipid Nanoparticles
    Kazuki Hashiba, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Yuichi Suzuki, Hirofumi Ebe, Okazaki Arimichi, Hideyoshi Harashima, Yusuke Sato · 2024 · Nano Letters
  51. Dynamically covalent lipid nanoparticles mediate CRISPR-Cas9 genome editing against choroidal neovascularization in mice
    Desheng Cao, Junliang Zhu, Yang Guo, Yang Zhou, Jia Zeng, Yuanyuan Tu, Ziyin Zhao, Laiqing Xie, E. Song, Manhui Zhu et al. · 2025 · Science Advances
  52. Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown
    Sandra Noske, Michael Karimov, Achim Michael Aigner, Alexander Ewe · 2020 · Nanomaterials
  53. Elucidating the nanostructure of small interfering RNA-loaded lipidoid-polymer hybrid nanoparticles
    Anas Aljabbari, Abhijeet Girish Lokras, Jacob J. K. Kirkensgaard, Thomas Rades, Henrik Franzyk, Aneesh Thakur, Yibang Zhang, Camilla Foged · 2022 · Journal of Colloid and Interface Science
  54. The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles
    Timothy H. Cheung, Molly Sandra Shoichet · 2025 · Langmuir
  55. Engineering the biophysical properties of lipid nanostructures for drug delivery
    Julian Menge, Chenjing Yang, David A. Weitz, Kevin Jahnke · 2026 · Communications Materials
  56. Microfluidics for the Production of Nanomedicines: Considerations for Polymer and Lipid-based Systems
    Sarah Streck, Linda Hong, Ben J. Boyd, Arlene McDowell · 2019 · Pharmaceutical Nanotechnology
  57. Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles
    Yusuke Hirai, H. Hirose, Miki Imanishi, Tomohiro Asai, Shiroh Futaki · 2021 · Scientific Reports
  58. Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug
    Igor V. Zhigaltsev, Yuen Yi C. Tam, Jayesh A. Kulkarni, Pieter R. Cullis · 2022 · Langmuir
  59. Controlled preparation of lipid nanoparticles in microreactors: Mixing time, morphology and mRNA delivery
    Daixin Chen, Zhikai Liu, Letao Guo, Lixia Yang, Yuchao Zhao, Mei Yang · 2025 · Chemical Engineering Journal
  60. Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme
    Haiyang Tong, Zesen Ma, Jin Yu, Dongsheng Li, Qingjun Zhu, Huajian Shi, Yun Wu, Hongyi Yang, Yanmin Zheng, Demeng Sun et al. · 2025 · ACS Chemical Biology
  61. Peeling back the layers of immunogenicity in Cas9-based genomic medicine
    Virpi Stigzelius, Anna Lina Cavallo, Rakesh Kantilal Chandode, Roberto Nitsch · 2025 · Molecular Therapy
  62. Martini 3 Building Blocks for Lipid Nanoparticle Design
    Lisbeth R. Kjølbye, Mariana Valério, Markéta Paloncýová, Luís Borges-Araújo, Roberto Pestana-Nobles, Fabian Grünewald, Bart M. H. Bruininks, Rocío Araya‐Osorio, Martin Šrejber, Raúl Mera‐Adasme et al. · 2025 · Journal of Chemical Theory and Computation
  63. Design principles of lipid nanoparticles for RNA delivery
    Mariah Lynn Arral, Kathryn A. Whitehead · 2026 · Nature Reviews Bioengineering
  64. Ionizable drug delivery systems for efficient and selective gene therapy
    Yuqi Zhang, Ranran Guo, Yonghu Chen, Tian‐Cheng Li, Wen-Zhen Du, Rongwu Xiang, Jibin Guan, Yupeng Li, Yuanyu Huang, Zhiqiang Yu et al. · 2023 · Military Medical Research
  65. M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy
    Ha Eun Shin, Jun‐Hyeok Han, Seungyong Shin, Ga‐Hyun Bae, Boram Son, Taehyung Kim, Hee Ho Park, Chun Gwon Park, Wooram Park · 2024 · Acta Pharmaceutica Sinica B
  66. Formulation strategies, preparation methods, and devices for pulmonary delivery of biologics
    Kai Berkenfeld, Simone Pinto Carneiro, Carolina Corzo, Flavia Laffleur, Sharareh Salar-Behzadi, Benjamin Winkeljann, Golbarg Esfahani · 2024 · European Journal of Pharmaceutics and Biopharmaceutics
  67. Loading of Extracellular Vesicles with Nucleic Acids via Hybridization with Non‐Lamellar Liquid Crystalline Lipid Nanoparticles
    Johannes Bader, Pascal Rüedi, Valeria Mantella, Silvana Geisshüsler, Finn Brigger, Bilal Muhammad Qureshi, Jaime Ortega Arroyo, Elita Montanari, Jean‐Christophe Leroux · 2024 · Advanced Science
  68. Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury
    Hongqian Zhang, Feng Ding, Zongwei Zhu, Qian Sun, Chuanxu Yang · 2022 · International Journal of Pharmaceutics
  69. The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review
    Matthew T. J. Halma, Jessica Rose, Alan Jenks, Theresa Anne Lawrie · 2023 · J — Multidisciplinary Scientific Journal
  70. The cutting-edge technologies of siRNA delivery and their application in clinical trials
    Kyuri Lee, Bora Jang, You-ri Lee, Eun-young Suh, Ji-seon Yoo, Mi-jin Lee, Joo-Young Lee, Hyukjin Lee · 2018 · Archives of Pharmacal Research
  71. Phospholipid‐Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver
    Wunan Zhang, Roland Böttger, Zhu Qin, Jayesh A. Kulkarni, Julian Vogler, Pieter R. Cullis, Shyh‐Dar Li · 2019 · Small
  72. Advancing mRNA technologies for therapies and vaccines: An African context
    Kairuz, Dylan, Samudh, Nazia, Ely, Abdullah, Arbuthnot, Patrick, Bloom, Kristie · 2022 · Frontiers in Immunology
  73. Advancing cancer treatments: The role of oligonucleotide-based therapies in driving progress
    Bogdan Razvan Dume, Emilia Licărete, Manuela Banciu · 2024 · Molecular Therapy — Nucleic Acids
  74. Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages
    Joshua Iscaro, Haitao Yu, Natalia P. Martínez, Santhni Subramaniam, Paul Joyce, Hao Wang, Brendan Dyett, John White, Clive A. Prestidge, Calum John Drummond et al. · 2024 · Advanced Functional Materials
  75. Recent Advancements in mRNA Vaccines: From Target Selection to Delivery Systems
    Zhongyan Wu, Weilu Sun, Hailong Qi · 2024 · Vaccines
  76. Intelligent Design of Lipid Nanoparticles for Enhanced Gene Therapeutics
    Yichen Yuan, Ying Li, Guo Li, Liqun Lei, Xingxu Huang, Ming Li, Yuan Yao · 2025 · Molecular Pharmaceutics
  77. Hybrid lipid nanoparticles derived from human mesenchymal stem cell extracellular vesicles by microfluidic sonication for collagen I mRNA delivery to human tendon progenitor stem cells
    Rubén Pareja Tello, Erwin Pavel Lamparelli, Maria Camilla Ciardulli, Jouni J. Hirvonen, Gonçalo Barreto, Nicola Maffulli, Giovanna Della Porta, Hélder A. Santos · 2025 · Biomaterials Science
  78. Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy
    Steffen Honrath, Michael Burger, Jean‐Christophe Leroux · 2025 · International Journal of Pharmaceutics
  79. Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X-ray Scattering and Cryotransmission Electron Microscopic Studies
    Kenichi Aburai, Kentaro Hatanaka, Shin Takano, Shota Fujii, Kazuo Sakurai · 2020 · Langmuir
  80. Synthesis and bioactivity of readily hydrolysable novel cationic lipids for potential lung delivery application of mRNAs
    Yihua Pei, Yanjie Bao, Cristiano Sacchetti, Juthamart Brady, Kyra Gillard, Hailong Yu, Scott Roberts, Kumar Rajappan, Steven P. Tanis, Carlos G. Pérez‐García et al. · 2022 · Chemistry and Physics of Lipids
  81. Light and pH responsive catanionic vesicles based on a chalcone/flavylium photoswitch for smart drug delivery: From molecular design to the controlled release of doxorubicin
    Dmitriy Moreira, Oren Regev, Nuno Basílio, Eduardo Figueira Marques · 2023 · Journal of Colloid and Interface Science
  82. PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
    Chang Liu, Xiaojun Zhang, Huiying Yang, Meijun Zhao, Yanhong Liu, Risheng Zhao, Ziqing Li, Meng Juan Sun · 2023 · International Journal of Pharmaceutics
  83. Advancement in lipid-based nanocomposites for theranostic applications in lung carcinoma treatment
    Viola Colaco, Amrita Arup Roy, Gaurisha Alias Resha Ramnath Naik, Arijit Mondal, Srinivas Mutalik, Namdev L. Dhas · 2023 · OpenNano
  84. Highly Branched Poly(β‐amino ester)s for Efficient mRNA Delivery and Nebulization Treatment of Silicosis
    Haiyang Yong, Yunze Tian, Zhili Li, Chenfei Wang, Dezhong Zhou, Jiangzheng Liu, Xiaobei Huang, Jianzhong Li · 2025 · Advanced Materials
  85. Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries
    Andrew R. Hanna, Sarah J. Shepherd, Gregory Datto, Rakan D. El-Mayta, Taigh Anderson, Isabel B. Navarro, Adele S. Ricciardi, Marshall Scott Padilla, Neha Srikumar, Shuran Zhang et al. · 2025 · ACS Nano
  86. FAM13A as potential therapeutic target in modulating TGF-β-induced airway tissue remodeling in COPD
    Anthony Tam, Pascal Leclair, Ling Vicky Li, Chen Xi Yang, Xuan Li, Dominik Witzigmann, Jayesh A. Kulkarni, Tillie‐Louise Hackett, Delbert R. Dorscheid, Gurpreet Kaur Singhera et al. · 2021 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  87. Development of a Combined Lipid-Based Nanoparticle Formulation for Enhanced siRNA Delivery to Vascular Endothelial Cells
    Yutong He, Dongdong Bi, Josée A. Plantinga, Grietje Molema, Jeroen Bussmann, Jan A. A. M. Kamps · 2022 · Pharmaceutics
  88. A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement
    Anindita De, Young Tag Ko · 2022 · Expert Opinion on Drug Delivery
  89. A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs
    Hiroki Tanaka, Yuka Sato, Tomoya Nakabayashi, Akira Tanaka, Kazuma Nishio, Chika Matsumoto, Atsuya Matsumaru, Takuma Yamakawa, Kota Ishizaki, Keisuke Ueda et al. · 2025 · Nano Letters
  90. Fluorinated Ionizable Lipids for Efficient Spleen-Targeted mRNA Delivery in Cancer Immunotherapy
    Yanhao Zhang, Bing Shao, Kai Jiang, Jie Cen, Yang Liu, Jiajia Tan, Lin Zhang, Keyu Li, Chengying You, Zhihua He et al. · 2025 · Journal of the American Chemical Society
  91. Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study
    Erica Quagliarini, Junbiao Wang, Serena Renzi, Lishan Cui, Luca Digiacomo, Gianmarco Ferri, Luca Pesce, Valentina De Lorenzi, Giulia Matteoli, Heinz Wilfried Amenitsch et al. · 2022 · ACS Applied Materials & Interfaces
  92. Cholesterol‐Derived Mannosylated Polypeptide‐Formed Lipid Nanoparticles for Efficient in Vivo mRNA Delivery
    Jin‐Yue Zeng, Shonya Lingesh, Nithiyaa Bala Krishnan, Brandon Yi Loong Seow, Min Liu, Qingfeng Chen, Yi Yan Yang · 2025 · Small Methods
  93. Recent Advances in Lipid Nanoparticles: Nucleic Acid Therapeutics and Targeting Strategies
    Sharat Sarmah, Sourav Baidya, Mrinmoy De · 2025 · Small
  94. Inhaled siRNA Formulations for Respiratory Diseases: From Basic Research to Clinical Application
    Yulin Fan, Zhijun Yang · 2022 · Pharmaceutics
  95. Lipid‐based nucleic acid therapeutics with in vivo efficacy
    Md Abu Sufian, Marc Antoniu Ilies · 2022 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  96. Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection
    Edo Kon, Inbal Hazan‐Halevy, Daniel Rosenblum, Niv Cohen, Sushmita Chatterjee, Nuphar Veiga, Pia Raanani, Osnat Bairey, Ohad Benjamini, Arnon Nagler et al. · 2020 · Pharmaceutics
  97. Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models – a comprehensive review
    Yusuf M. Idres, Adi Idris, Wenqing Gao · 2025 · Drug Delivery and Translational Research
  98. Harnessing the Electron-Withdrawing Inductive Effect of One-Component Ionizable Amphiphilic Janus Dendrimers Unveils Cation−π Interactions and Their Important Roles to Targeted mRNA Delivery
    Mahwish Arshad, Elena N. Atochina‐Vasserman, Devendra S. Maurya, Juncheng Lu, Nathan A. Ona, Jessica A. Vasserman, Brieyanna C. McWilliams, Houping Ni, Sydni Berkihiser, W. Park et al. · 2025 · Journal of the American Chemical Society
  99. Endogenous Corticosteroid Derived Lipid Nanoparticles (Cortico LNPs) Enable Selective mRNA Delivery to the Spleen
    Ivan Isaac, Luv Patel, Dong Soo Yun, Seungman Park, Chandrabali Bhattacharya · 2025 · Small
  100. The Potential of Nanomedicine to Unlock the Limitless Applications of mRNA
    Laura Taina-González, María de la Fuente · 2022 · Pharmaceutics