Tumor‐Specific Photothermal‐Therapy‐Assisted Immunomodulation via Multiresponsive Adjuvant Nanoparticles
Abstract
Multiresponsive adjuvant nanoparticles (RMmAGL) are fabricated to perform tumor‐specific photothermal therapy while regulating the behavior of tumor‐associated immune cells for primary tumor eradication and metastasis inhibition. Core–satellite‐like RMmAGL have a core of mannose‐functionalized mesoporous silica nanoparticles loaded with the TLR7 agonist imiquimod (R837@MSN‐mannose) connected via hydrazone bonds to satellites of glutamine (Glu)‐ and lysine (Lys)‐comodified gold nanoparticles (AuNPs‐Glu/Lys). During therapy, the acidic environment in tumor tissue cleaves the hydrazone bonds to release AuNPs‐Glu/Lys, which further accumulate in tumor cells. After internalization, photothermal agents (aggregated AuNPs‐Glu/Lys) are generated in situ through the intratumoral enzyme‐catalyzed reaction between Glu and Lys, resulting in tumor‐specific photothermal therapy. The detachment of AuNPs‐Glu/Lys also triggers the release of R837, which matured dendritic cells (DCs) via a vaccine‐like mechanism along with the tumor‐associated antigens generated by photothermal therapy. These matured DCs further activates surrounding T cells for immunotherapy. Moreover, the resulting free MSN‐mannose serves as an artificial glycocalyx to continuously induce the polarization of tumor‐associated macrophages from an immunosuppressive phenotype to an inflammatory phenotype, thus further enhancing immunotherapy. Both in vivo and in vitro experiments demonstrate significant inhibition of malignant tumors after therapy.
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Gold nanoparticles co-modified with glutamine and lysine can generate tumor-specific photothermal therapy by in situ generation of photothermal agents through an intra-tumor enzyme-catalyzed reaction.
“For example, gold nanoparticles co-modified with glutamine and lysine can generate tumor-specific photothermal therapy by in situ generation of photothermal agents through an intra-tumor enzyme-catalyzed reaction.89”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [89]
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Liu, T., Zhu, M., Chang, X., Tang, X., Yuan, P., Tian, R., Zhu, Z., Zhang, Y., & Chen, X.
- Affiliations
- Xi'an Jiaotong University (CN)
- Corresponding author
- Zhang, Yanmin
- Chen, Xin
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2023-04-02
- Volume
- 35
- Issue
- 18
- Pages
- e2300086-e2300086
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W4320709511
- Cited by
- 98
- References
- 52
- Citations by year
- 2026: 12 · 2025: 39 · 2024: 38 · 2023: 9
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82272141)
- Natural Science Foundation of Shaanxi Province (2022JZ‐48, 2023‐CX‐TD‐65)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- photothermal therapy, TLR7 agonist, imiquimod, mesoporous silica nanoparticles, gold nanoparticles, enzyme-responsive drug release, dendritic cell maturation, tumor-associated macrophage polarization, tumor-associated antigens, metastasis suppression, cancer immunotherapy
- MeSH terms
- Photothermal Therapy, Adjuvants, Immunologic, Gold, Humans, Immunotherapy, Mannose, Neoplasms, Cell Line, Tumor, Toll-Like Receptor 7, Metal Nanoparticles
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