The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Thermoresponsive in Situ Forming Hydrogel with Sol–Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing
Abstract
An in situ forming hydrogel has emerged as a promising wound dressing recently. As physically cross-linked hydrogels are normally unstable, most in situ forming hydrogels are chemically cross-linked. However, big concerns have remained regarding the slow gelation and the potential toxicity of residual functional groups from cross-linkers or the polymer matrix. Herein, we report a sprayable in situ forming hydrogel composed of poly( N -isopropylacrylamide 166 - co - n -butyl acrylate 9 )-poly(ethylene glycol)-poly( N -isopropylacrylamide 166 - co - n -butyl acrylate 9 ) copolymer (P(NIPAM 166 - co -nBA 9 )-PEG-P(NIPAM 166 - co -nBA 9 ), denoted as PEP) and silver-nanoparticles-decorated reduced graphene oxide nanosheets (Ag@rGO, denoted as AG) in response to skin temperature. This thermoresponsive hydrogel exhibits intriguing sol–gel irreversibility at low temperatures for the stable dressing of a wound, which is attributed to the inorganic/polymeric dual network and abundant coordination interactions between Ag@rGO nanosheets and PNIPAM. The biocompatibility and antibacterial ability against methicillin-resistant Staphylococcus aureus (MRSA) of this PEP-AG hydrogel wound dressing are confirmed in vitro and in vivo, which could transparently promote the healing of a MRSA-infected skin defect.
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Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
You, C., Han, C., Wang, X., Zheng, Y., Li, Q., Hu, X., & Sun, H. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1792-8 · Cited by 447
Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Cheng, S., Wang, H., Pan, X., Zhang, C., Zhang, K., Chen, Z., Dong, W., Xie, A., & Qi, X. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c25014 · Cited by 386
Multifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels
Asadi, N., Pazoki-Toroudi, H., Del Bakhshayesh, A. R., Akbarzadeh, A., Davaran, S., & Annabi, N. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.202 · Cited by 312
Status and future scope of hydrogels in wound healing: Synthesis, materials and evaluation
Xiang, J., Shen, L., & Hong, Y. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.109609 · Cited by 282
Metadata
- Authors
- Yan, X., Fang, W.-W., Xue, J., Sun, T.-C., Dong, L., Zha, Z., Qian, H., Song, Y.-H., Zhang, M., Gong, X., Lu, Y., & He, T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-08-20
- Volume
- 13
- Issue
- 9
- Pages
- 10074-10084
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2969932557
- Cited by
- 228
- References
- 3
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yan, X., Fang, W.-W., Xue, J., Sun, T.-C., Dong, L., Zha, Z., Qian, H., Song, Y.-H., Zhang, M., Gong, X., Lu, Y., & He, T. (2019). Thermoresponsive in Situ Forming Hydrogel with Sol–Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing. ACS Nano. https://doi.org/10.1021/acsnano.9b02845
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