The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release
Abstract
Diabetic wound healing and angiogenesis remain a worldwide challenge for both clinic and research. The use of adipose stromal cell derived exosomes delivered by bioactive dressing provides a potential strategy for repairing diabetic wounds with less scar formation and fast healing. In this study, we fabricated an injectable adhesive thermosensitive multifunctional polysaccharide-based dressing (FEP) with sustained pH-responsive exosome release for promoting angiogenesis and diabetic wound healing. The FEP dressing possessed multifunctional properties including efficient antibacterial activity/multidrug-resistant bacteria, fast hemostatic ability, self-healing behavior, and tissue-adhesive and good UV-shielding performance. FEP@exosomes (FEP@exo) can significantly enhance the proliferation, migration, and tube formation of endothelial cells in vitro . In vivo results from a diabetic full-thickness cutaneous wound model showed that FEP@exo dressing accelerated the wound healing by stimulating the angiogenesis process of the wound tissue. The enhanced cell proliferation, granulation tissue formation, collagen deposition, remodeling, and re-epithelialization probably lead to the fast healing with less scar tissue formation and skin appendage regeneration. This study showed that combining bioactive molecules into multifunctional dressing should have great potential in achieving satisfactory healing in diabetic and other vascular-impaired related wounds.
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Factors affecting wound healing
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Hu, Y., Rao, S.-S., Wang, Z.-X., Cao, J., Tan, Y.-J., Luo, J., Li, H.-M., Zhang, W.-S., Chen, C.-Y., & Xie, H. (2018) · Theranostics · doi:10.7150/thno.21234 · Cited by 574
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Self-citationEfficient production and enhanced tumor delivery of engineered extracellular vesicles
Watson, D. C., Bayik, D., Srivatsan, A., Bergamaschi, C., Valentin, A., Niu, G., Bear, J., Monninger, M., Sun, M., Morales-Kastresana, A., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.003 · Cited by 385
Cited by
Selection of Appropriate Wound Dressing for Various Wounds
Shi, C., Wang, C., Liu, H., Li, Q., Li, R., Zhang, Y., Liu, Y., Shao, Y., & Wang, J. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00182 · Cited by 522
Self-citationHu, H., Dong, L., Bu, Z., Shen, Y., Luo, J., Zhang, H., Zhao, S., Lv, F., & Liu, Z. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1778883 · Cited by 310
Wang, Y., Cao, Z., Wei, Q., Ma, K., Hu, W., Huang, Q., Su, J., Li, H., Zhang, C., & Fu, X. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.018 · Cited by 225
Chitosan and hyaluronic-based hydrogels could promote the infected wound healing
Bai, Q., Gao, Q., Hu, F., Zheng, C., Chen, W., Sun, N., Liu, J., Zhang, Y., Wu, X., & Lu, T. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123271 · Cited by 125
Fu, M., Zhao, Y., Wang, Y., Li, Y., Wu, M., Liu, Q., Hou, Z., Lu, Z., Wu, K., & Guo, J. (2023) · Small · doi:10.1002/smll.202205489 · Cited by 107
Metadata
- Authors
- Wang, M., Wang, C., Chen, M., Xi, Y., Cheng, W., Mao, C., Xu, T., Zhang, X., Lin, C., Gao, W., Guo, Y., & Lei, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-09-04
- Volume
- 13
- Issue
- 9
- Pages
- 10279-10293
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2971886371
- Cited by
- 550
- References
- 6
- FWCI
- 34.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, M., Wang, C., Chen, M., Xi, Y., Cheng, W., Mao, C., Xu, T., Zhang, X., Lin, C., Gao, W., Guo, Y., & Lei, B. (2019). Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release. ACS Nano. https://doi.org/10.1021/acsnano.9b03656
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