Cited by 261Micro and Nano RoboticsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research Studies

Photoacoustic Imaging-Trackable Magnetic Microswimmers for Pathogenic Bacterial Infection Treatment

Xie, Lisi, Pang, Xin, Yan, Xiaohui, Dai, Qixuan, Lin, Huirong, Ye, Jing, Cheng, Yi, Zhao, Qingliang +4 more·2020·ACS Nano

Abstract

Micro/nanorobots have been extensively explored as a tetherless small-scale robotic biodevice to perform minimally invasive interventions in hard-to-reach regions. Despite the emergence of versatile micro/nanorobots in recent years, matched in vivo development remains challenging, limited by unsatisfactory integration of core functions. Herein, we report a polydopamine (PDA)-coated magnetic microswimmer consisting of a magnetized Spirulina (MSP) matrix and PDA surface. Apart from the properties of the existing MSP ( e.g., robust propulsion, natural fluorescence, tailored biodegradation, and selective cytotoxicity), the introduced PDA coating enhances the photoacoustic (PA) signal and photothermal effect of the MSP, thus making PA image tracking and photothermal therapy possible. Meanwhile, the PDA’s innate fluorescence quenching and diverse surface reactivity allows an off–on fluorescence diagnosis with fluorescence probes ( e.g., coumarin 7). As a proof of concept, real-time image tracking (by PA imaging) and desired theranostic capabilities of PDA-MSP microswimmer swarms are demonstrated for the treatment of pathogenic bacterial infection. Our study suggests a feasible antibacterial microrobot for in vivo development and a facile yet versatile functionalization strategy of micro/nanorobots.

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Crossref · 10.1021/acsnano.9b06731

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  • A magnetized Spirulina sp. matrix coated with polydopamine (MSp-PDA) microswimmer enabled noninvasive real-time photoacoustic imaging and photothermal therapy for theranostics of multidrug-resistant Klebsiella pneumoniae infection.

    “Noninvasive and real-time image tracking (by photoacoustic imaging) of the MSp-PDA microswimmer was accomplished and its photothermal therapy for the theranostics of pathogenic multi-drug-resistant Klebsiella pneumoniae infection was also demonstrated.”

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Authors
Xie, L., Pang, X., Yan, X., Dai, Q., Lin, H., Ye, J., Cheng, Y., Zhao, Q., Ma, X., Zhang, X., Liu, G., & Chen, X.
Affiliations
  • Xiamen University (CN)
  • Harbin Institute of Technology (CN)
  • National Institutes of Health (US)
Corresponding author
  • Yan, Xiaohui
  • Liu, Gang
  • Chen, Xiaoyuan
Venue
ACS Nano
Published
2020-03-03
Volume
14
Issue
3
Pages
2880-2893
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W3009854819
Cited by
261
References
86
Citations by year
2026: 22 · 2025: 42 · 2024: 58 · 2023: 35 · 2022: 51 · 2021: 33 · 2020: 20
FWCI
34.09
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Program for New Century Excellent Talents in University (NCE-13-0502)
  • Ministry of Science and Technology of the People's Republic of China (2017YFA0205201, 2018YFA0107301)
  • U.S. Department of Health and Human Services (ZIA EB000073)
  • National Natural Science Foundation of China (81422023, 81603015, 81871404, 81925019, U1705281)
  • the Fundamental Research Funds for the Central Universities of China (20720190076, 20720190088, 20720200019)
Topics
  • Physical Sciences › Physics and Astronomy › Condensed Matter Physics › Micro and Nano Robotics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Keywords
magnetic microswimmers, micro/nanorobots, photoacoustic imaging, polydopamine coating, photothermal therapy, bacterial infection treatment, theranostics, fluorescence quenching, off-on fluorescence
MeSH terms
Animals, Anti-Bacterial Agents, Bacterial Infections, Fluorescent Dyes, Indoles, Klebsiella pneumoniae, Microbial Sensitivity Tests, Phototherapy, Polymers, Clarithromycin, Drug Resistance, Multiple, Bacterial, Mice, Spirulina, Magnetic Phenomena, Photoacoustic Techniques, Optical Imaging

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