Recent Advances in Fluorescent Theranostics for Alzheimer’s Disease: A Comprehensive Survey on Design, Synthesis, and Properties

NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

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Lecanemab in early Alzheimer's disease

van Dyck, C. H., Swanson, C. J., Aisen, P., Bateman, R. J., Chen, C., Gee, M., Kanekiyo, M., Li, D., Reyderman, L., Cohen, S., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2212948 · Cited by 5,678 · see citing works

Alzheimer's disease

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Applications of Fluorine in Medicinal Chemistry

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Alzheimer’s Disease

Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works

2018 Alzheimer's disease facts and figures

Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912 · see citing works

Inorganic Nanoparticles for MRI Contrast Agents

Na, H. B., Song, I. C., & Hyeon, T. (2009) · Advanced Materials · doi:10.1002/adma.200802366 · Cited by 1,776 · see citing works

Donanemab in Early Alzheimer’s Disease

Mintun, M. A., Lo, A. C., Duggan Evans, C., Wessels, A. M., Ardayfio, P. A., Andersen, S. W., Shcherbinin, S., Sparks, J., Sims, J. R., Brys, M., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2100708 · Cited by 1,728 · see citing works

Theranostics: Combining Imaging and Therapy

Kelkar, S. S., & Reineke, T. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200151q · Cited by 1,394 · see citing works

The global burden of neurological disorders: translating evidence into policy

Feigin, V. L., Vos, T., Nichols, E., Owolabi, M. O., Carroll, W. M., Dichgans, M., Deuschl, G., Parmar, P., Brainin, M., & Murray, C. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30411-9 · Cited by 1,303 · see citing works

Harrison's Principles of Internal Medicine

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Through-skull fluorescence imaging of the brain in a new near-infrared window

Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052 · see citing works

Global estimates on the number of persons across the Alzheimer's disease continuum

Gustavsson, A., Norton, N., Fast, T., Frölich, L., Georges, J., Holzapfel, D., Kirabali, T., Krolak‐Salmon, P., Rossini, P. M., Ferretti, M. T., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12694 · Cited by 895 · see citing works

Mechanism of thioflavin T binding to amyloid fibrils

Khurana, R., Coleman, C., Ionescu‐Zanetti, C., Carter, S. A., Krishna, V., Grover, R. K., Roy, R., & Singh, S. S. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.06.006 · Cited by 833 · see citing works

Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms

Rogosnitzky, M., & Branch, S. (2016) · BioMetals · doi:10.1007/s10534-016-9931-7 · Cited by 769 · see citing works

Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status

Groenning, M. (2009) · Journal of Chemical Biology · doi:10.1007/s12154-009-0027-5 · Cited by 643 · see citing works

Alzheimer’s disease drug development pipeline: 2020

Cummings, J., Lee, G., Ritter, A., Sabbagh, M., & Zhong, K. (2020) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12050 · Cited by 557 · see citing works

Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins

Taniguchi, S., Suzuki, N., Masuda, M., Hisanaga, S., Iwatsubo, T., Goedert, M., & Hasegawa, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408714200 · Cited by 540 · see citing works

Rational Design of Near-Infrared Aggregation-Induced-Emission-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultrasensitivity and High-Fidelity

Fu, W., Yan, C., Guo, Z., Zhang, J., Zhang, H., Tian, H., & Zhu, W. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12820 · Cited by 448 · see citing works

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

Viña, J., & Lloret, A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100501 · Cited by 447 · see citing works

ADAMS AND VICTOR'S PRINCIPLES OF NEUROLOGY

Zunt, J. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181dad651 · Cited by 420 · see citing works

Molecular Rotors: What Lies Behind the High Sensitivity of the Thioflavin-T Fluorescent Marker

Amdursky, N., Erez, Y., & Huppert, D. (2012) · Accounts of Chemical Research · doi:10.1021/ar300053p · Cited by 415 · see citing works

Congo red and protein aggregation in neurodegenerative diseases

Frid, P., Anisimov, S. V., & Popović, N. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.08.001 · Cited by 398 · see citing works

Handbook of clinical neuropsychology

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In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

Nesterov, E. E., Skoch, J. M., Hyman, B. T., Klunk, W. E., Bacskai, B. J., & Swager, T. M. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200500845 · Cited by 337 · see citing works

Synthesis and application of coumarin fluorescence probes

Sun, X., Liu, T., Sun, J., & Wang, X. (2020) · RSC Advances · doi:10.1039/c9ra10290f · Cited by 314 · see citing works

Interrogating Amyloid Aggregates using Fluorescent Probes

Aliyan, A., Cook, N. P., & Martı́, A. A. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00404 · Cited by 295 · see citing works

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

Mendgen, T., Steuer, C., & Klein, C. D. P. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm201243p · Cited by 292 · see citing works

Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

Zhou, H., Zeng, X., Li, A., Zhou, W., Tang, L., Hu, W., Fan, Q., Meng, X., Deng, H., Duan, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19945-w · Cited by 289 · see citing works

Phenothiazine: the seven lives of pharmacology's first lead structure

Ohlow, M. J., & Moosmann, B. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.01.001 · Cited by 283 · see citing works

Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

Morris, E., Chalkidou, A., Hammers, A., Peacock, J. L., Summers, J. A., & Keevil, S. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3228-x · Cited by 249 · see citing works

Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression

Tolar, M., Hey, J., Power, A., & Abushakra, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126355 · Cited by 246 · see citing works

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering

Cummings, J., Aisen, P., Lemere, C., Atri, A., Sabbagh, M., & Salloway, S. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00838-z · Cited by 224 · see citing works

Rational Design of Near-Infrared-II Organic Molecular Dyes for Bioimaging and Biosensing

Li, B., Zhao, M., & Zhang, F. (2020) · ACS Materials Letters · doi:10.1021/acsmaterialslett.0c00157 · Cited by 205 · see citing works

Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

Staderini, M., Martín, M. A., Bolognesi, M. L., & Menéndez, J. C. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00337c · Cited by 188 · see citing works

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.044 · Cited by 179 · see citing works

SPECT and PET imaging in Alzheimer’s disease

Valotassiou, V., Malamitsi, J., Papatriantafyllou, J., Dardiotis, E., Tsougos, I., Psimadas, D., Alexiou, S., Hadjigeorgiou, G., & Georgoulias, P. (2018) · Annals of Nuclear Medicine · doi:10.1007/s12149-018-1292-6 · Cited by 169 · see citing works

Rhodanine‐Based Tau Aggregation Inhibitors in Cell Models of Tauopathy

Bulic, B., Pickhardt, M., Khlistunova, I., Biernat, J., Mandelkow, E., Mandelkow�, E., & Waldmann, H. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200704051 · Cited by 158 · see citing works

Dementia in low-income and middle-income countries: Different realities mandate tailored solutions

Ferri, C. P., & Jacob, K. S. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002271 · Cited by 154 · see citing works

Inhibition of beta-amyloid peptide aggregation by multifunctional carbazole-based fluorophores.

Yang, W.-G., Wong, Y., Ng, O. T. W., Bai, L.-P., Kwong, D., Ke, Y., Jiang, Z.-H., Li, H.-W., Yung, K. K. L., & Wong, M. (2012) · Angewandte Chemie · doi:10.1002/anie.201104150 · Cited by 120 · see citing works

Cyanines as New Fluorescent Probes for DNA Detection and Two-Photon Excited Bioimaging

Feng, X. J., Wu, P. L., Bolze, F., Leung, H. W. C., Li, K., Mak, N. K., Kwong, D. W. J., Nicoud, J., Cheah, K., & Wong, M. S. (2010) · Organic Letters · doi:10.1021/ol100474b · Cited by 119 · see citing works

An Activatable NIR‐II Fluorescent Reporter for In Vivo Imaging of Amyloid‐β Plaques

Miao, J., Miao, M., Jiang, Y., Zhao, M., Li, Q., Zhang, Y., An, Y., Pu, K., & Miao, Q. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202216351 · Cited by 118 · see citing works

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands

Blaikie, L., Kay, G., & Lin, P. K. T. (2019) · MedChemComm · doi:10.1039/c9md00337a · Cited by 113 · see citing works

A short review on NIR-II organic small molecule dyes

Li, L., Dong, X., Li, J., & Wei, J. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108756 · Cited by 113 · see citing works

Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3β and Tau-Aggregation Inhibitors

Gandini, A., Bartolini, M., Tedesco, D., Martínez‐González, L., Roca, C., Campillo, N. E., Zaldívar-Díez, J., Pérez, C., Zuccheri, G., Miti, A., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00610 · Cited by 112 · see citing works

Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer’s Disease

Jie, C. V. M. L., Treyer, V., Schibli, R., & Mu, L. (2021) · Pharmaceuticals · doi:10.3390/ph14020110 · Cited by 111 · see citing works

Review of the advances in treatment for Alzheimer disease: strategies for combating β-amyloid protein

Folch, J., Ettcheto, M., Petrov, D., Abad, S., Pedrós, I., Marin, M., Olloquequi, J., & Camins, A. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.03.019 · Cited by 104 · see citing works

PET Neuroimaging of Alzheimer's Disease: Radiotracers and Their Utility in Clinical Research

Bao, W., Xie, F., Zuo, C., Guan, Y., & Huang, Y. H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.624330 · Cited by 102 · see citing works

A Theranostic Agent for in Vivo Near-Infrared Imaging of β-Amyloid Species and Inhibition of β-Amyloid Aggregation

Li, Y., Xu, D., Ho, S.-L., Li, H.-W., Yang, R., & Wong, M. S. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.047 · Cited by 102 · see citing works

Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease

Zhang, T., Chen, X., Yuan, C., Pang, X., Shangguan, P., Liu, Y., Han, L., Sun, J., Lam, J. W. Y., Liu, Y., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202211550 · Cited by 102 · see citing works

Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for Soluble and Insoluble Amyloid β Aggregates in Alzheimer’s Disease

Sun, L., Cho, H.-J., Sen, S., Arango, A. S., Huynh, T. T., Huang, Y., Bandara, N., Rogers, B. E., Tajkhorshid, E., & Mirica, L. M. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c05470 · Cited by 100 · see citing works

Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide

Folch, J., Ettcheto, M., Petrov, D., Abad, S., Pedrós, I., Marin, M., Olloquequi, J., & Camins, A. (2015) · Neurología · doi:10.1016/j.nrl.2015.03.012 · Cited by 98 · see citing works

A cruciform phthalocyanine pentad-based NIR-II photothermal agent for highly efficient tumor ablation

Pan, H., Li, S., Kan, J., Gong, L., Lin, C., Liu, W., Qi, D., Wang, K., Yan, X., & Jiang, J. (2019) · Chemical Science · doi:10.1039/c9sc02674f · Cited by 97 · see citing works

Frontiers in Probing Alzheimer’s Disease Biomarkers with Fluorescent Small Molecules

Jun, Y. W., Cho, S. W., Jung, J., Huh, Y., Kim, Y. S., Kim, D., & Ahn, K. H. (2019) · ACS Central Science · doi:10.1021/acscentsci.8b00951 · Cited by 96 · see citing works

Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer’s disease

Zhang, Y., Wang, Y., Shi, C., Shen, M., & Lü, F. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00230-9 · Cited by 93 · see citing works

Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level

Rodríguez‐Rodríguez, C., Rimola, A., Rodrı́guez-Santiago, L., Ugliengo, P., Álvarez‐Larena, Á., Gutiérrez‐de‐Terán, H., Sodupe, M., & Gonzalez-Duarte, P. (2010) · Chemical Communications · doi:10.1039/b912396b · Cited by 91 · see citing works

Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast <i>In Vivo</i> NIR-II Imaging

Godard, A., Kalot, G., Pliquett, J., Busser, B., Le Guével, X., Wegner, K. D., Resch-Genger, U., Rousselin, Y., Coll, J.-L., Denat, F., et al. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00175 · Cited by 90 · see citing works

Development of Near-Infrared Fluorescent Probes for Use in Alzheimer’s Disease Diagnosis

Yang, J., Zeng, F., Ge, Y., Peng, K., Li, X., Li, Y., & Xu, Y. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00695 · Cited by 87 · see citing works

Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer’s Disease

Rai, H., Gupta, S., Kumar, S., Yang, J., Singh, S. K., Ran, C., & Modi, G. P. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01619 · Cited by 86 · see citing works

Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains

Ono, M., Hayashi, S., Matsumura, K., Kimura, H., Okamoto, Y., Ihara, M., Takahashi, R., Mori, H., & Saji, H. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn200002t · Cited by 83 · see citing works

Development of Phenothiazine-Based Theranostic Compounds That Act Both as Inhibitors of β-Amyloid Aggregation and as Imaging Probes for Amyloid Plaques in Alzheimer’s Disease

Dao, P., Ye, F., Liu, Y., Du, Z. Y., Zhang, K., Dong, C. Z., Meunier, B., & Chen, H. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00380 · Cited by 80 · see citing works

Fluoro-substituted cyanine for reliable in vivo labelling of amyloid-β oligomers and neuroprotection against amyloid-β induced toxicity

Li, Y., Xu, D., Sun, A., Ho, S., Poon, C., Chan, H., Ng, O. T.-W., Yung, K. K. L., Yan, H., Li, H., et al. (2017) · Chemical Science · doi:10.1039/c7sc03974c · Cited by 77 · see citing works

The approval of Aduhelm risks eroding public trust in Alzheimer research and the FDA

Karlawish, J. H., & Grill, J. D. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00540-6 · Cited by 73 · see citing works

Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer’s disease

Gyasi, Y. I., Pang, Y., Li, X., Gu, J.-X., Cheng, X., Liu, J., Xu, T., & Liu, Y. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111982 · Cited by 72 · see citing works

Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models

Iyaswamy, A., Wang, X., Krishnamoorthi, S., Kaliyamoorthy, V., Sreenivasmurthy, S. G., Durairajan, S. S. K., Song, J., Tong, B. C., Zhu, Z., Su, C.-F., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102280 · Cited by 72 · see citing works

Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation

Wang, X., Wang, C., Chan, H., Iyaswamy, A., Krishnamoorthi, S. K., Li, M., Li, H., & Wong, M. S. (2020) · Talanta · doi:10.1016/j.talanta.2020.121830 · Cited by 65 · see citing works

Strategic Design of Amyloid-β Species Fluorescent Probes for Alzheimer’s Disease

Su, D., Diao, W., Li, J., Pan, L., Zhang, X., Wu, X., & Mao, W. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00810 · Cited by 63 · see citing works

Sources of widefield fluorescence from the brain

Waters, J. (2020) · eLife · doi:10.7554/elife.59841 · Cited by 57 · see citing works

From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?

Bolognesi, M. L., Gandini, A., Prati, F., & Uliassi, E. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00151 · Cited by 54 · see citing works

Fluorescence Chemicals To Detect Insoluble and Soluble Amyloid-β Aggregates

Lee, D.-H., Kim, S., Kim, H. Y., & Kim, Y. S. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00199 · Cited by 54 · see citing works

Tricyclic phenothiazine and phenoselenazine derivatives as potential multi-targeting agents to treat Alzheimer's disease

Tin, G., Mohamed, T., Gondora, N., Beazely, M. A., & Rao, P. P. N. (2015) · MedChemComm · doi:10.1039/c5md00274e · Cited by 51 · see citing works

Versatile fluorescent probes for near-infrared imaging of amyloid-β species in Alzheimer's disease mouse model

Peng, C., Wang, X., Li, Y., Li, H., & Wong, M. S. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00161a · Cited by 51 · see citing works

Introducing Theranostics Journal - From the Editor-in-Chief

Chen, X. S. (2011) · Theranostics · doi:10.7150/thno/v01p0001 · Cited by 50 · see citing works

Longitudinal amyloid and tau PET imaging in Alzheimer's disease: A systematic review of methodologies and factors affecting quantification

Bollack, A., Pemberton, H., Collij, L. E., Markiewicz, P. J., Cash, D. M., Farrar, G., & Barkhof, F. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13158 · Cited by 49 · see citing works

Multimodal Theranostic Cyanine-Conjugated Gadolinium(III) Complex for In Vivo Imaging of Amyloid-β in an Alzheimer’s Disease Mouse Model

Wang, X., Chan, H., Desbois, N., Gros, C. P., Bolze, F., Li, Y., Li, H., & Wong, M. S. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01585 · Cited by 48 · see citing works

Theranostics could be big business in precision oncology

Arnold, C. (2022) · Nature Medicine · doi:10.1038/s41591-022-01759-6 · Cited by 47 · see citing works

NIR-Absorbing Dye Based on BF2-Bridged Azafulvene Dimer as a Strong Electron-Accepting Unit

Shimogawa, H., Murata, Y., & Wakamiya, A. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b02056 · Cited by 47 · see citing works

Small-molecule theranostics in Alzheimer's disease

Sarabia‐Vallejo, Á., López‐Alvarado, P., & Menéndez, J. C. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115382 · Cited by 45 · see citing works

An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells

Yang, Y., Li, S., Zhang, Q., Kuang, Y., Qin, A., Gao, M., Li, F., & Tang, B. Z. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00121b · Cited by 44 · see citing works

Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model

Li, Y., Chen, C., Xu, D., Poon, C., Ho, S., Zheng, R., Liu, Q., Song, G.-L., Li, H., & Wong, M. S. (2018) · ACS Omega · doi:10.1021/acsomega.8b00475 · Cited by 43 · see citing works

Detection of Aβ oligomers in early Alzheimer’s disease diagnose by in vivo NIR-II fluorescence imaging

Li, H., Wang, J., Li, Y., Chen, X., Zhang, W., Zhao, Y., Liu, G., & Pan, J. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131481 · Cited by 40 · see citing works

Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer’s Disease

Yang, J., Yang, J., Li, Y., Xu, Y., & Ran, C. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-018-1213-z · Cited by 38 · see citing works

Design and synthesis of tacrine-phenothiazine hybrids as multitarget drugs for Alzheimer’s disease

Hui, A., Chen, Y., Zhu, S.-J., Gan, C., Pan, J., & Zhou, A. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-0931-2 · Cited by 36 · see citing works

Near-Infrared Photooxygenation Theranostics Used for the Specific Mapping and Modulating of Amyloid-β Aggregation

Yang, J., Wang, X., Liu, J., Chi, W., Zhang, L., Xiao, L., & Yan, J. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04042 · Cited by 35 · see citing works

Nanoscale View of Amyloid Photodynamic Damage

Bondia, P., Torra, J., Tone, C. M., Sawazaki, T., del Valle, A., Sot, B., Nonell, S., Kanai, M., Sohma, Y., & Flors, C. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10632 · Cited by 33 · see citing works

The long road to a cure for Alzheimer’s disease is paved with failures

Moutinho, S. (2022) · Nature Medicine · doi:10.1038/s41591-022-02062-0 · Cited by 31 · see citing works

Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease

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Small Molecular Fluorescent Probes for Alzheimer's Disease Associated Active Species

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Fluorescent Light‐up Probe for the Detection of Protein Aggregates

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Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins

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Nanotechnology Driven Innovations in Modern Pharmaceutics: Therapeutics, Imaging, and Regeneration

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Mitochondria-targeting probes with large Stokes shift for detecting Amyloid-β and cellular viscosity changes

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Development of Donor–Acceptor Architecture-Based Potential Theranostic Fluorescent Probes for Alzheimer’s Disease

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Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

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Navigating the Biological Landscape: Barriers to Effective Theranostic Development and Delivery

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A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target Anti-AD Theranostic Agents

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