Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging
Abstract
A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo . In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
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Substitution of fluorine atoms in the boron center with N,N-dimethylpropargylamine followed by quaternization of amino groups allowed development of a highly water-soluble aza-BODIPY whose fluorescence emission reaches 1200 nm in biocompatible solutions (e.g., SWIR-WAZABY-01).
“A substitution of fluorine atoms in the boron center with N,N-dimethylpropargylamine followed by a quaternization of amino groups allowed the development of a highly water-soluble aza-BODIPY whose fluorescence emission reaches 1200 nm in biocompatible solutions (e.g., SWIR-WAZABY-01).65”
Cites
Novel aza-BODIPY based small molecular NIR-II fluorophores for <i>in vivo</i> imaging
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Characterizing short-wave infrared fluorescence of conventional near-infrared fluorophores
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J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging
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- Authors
- Godard, A., Kalot, G., Pliquett, J., Busser, B., Le Guével, X., Wegner, K. D., Resch-Genger, U., Rousselin, Y., Coll, J.-L., Denat, F., Bodio, E., Goze, C., & Sancey, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38000 Grenoble, France
- Federal Institute For Materials Research and Testing (DE)
- BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Str. 11, 12489 Berlin, Germany
- Corresponding author
- Bodio, Ewen
- Goze, Christine
- Sancey, Lucie
- ORCID
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-31
- Volume
- 31
- Issue
- 4
- Pages
- 1088-1092
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W3013421612
- Cited by
- 90
- References
- 2
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 14 · 2023: 7 · 2022: 25 · 2021: 14 · 2020: 13
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Bioconjugate Chemistry (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-16-CE07-0020, ANR-18-CE18-0012)
- Deutsche Forschungsgemeinschaft (1203/12-3)
- Minist?re de l'Enseignement Sup?rieur et de la Recherche Scientifique
- Fondation pour la Recherche M?dicale (FRM ECO201806006861)
- Centre National de la Recherche Scientifique
- Conseil r?gional de Bourgogne-Franche-Comt? (2015-9205AAO033S04139 / BG0003203)
- GEFLUC Grenoble
- France Life Imaging
- Plan Cancer (C18038CS)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- aza-BODIPY, NIR-II imaging, tumor imaging, in vivo imaging, fluorescent probes
- MeSH terms
- Aza Compounds, Boron Compounds, Coloring Agents, Humans, Infrared Rays, Water, Cell Line, Tumor, Optical Imaging
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