Global estimates on the number of persons across the Alzheimer's disease continuum
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Introduction: Global estimates on numbers of persons in early stages of Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet are needed to inform policy decisions on preventive measures and planning for future therapies targeting AD pathology. Methods: We synthesized the literature on prevalence across the AD continuum and derived a model estimating the number of persons, stratified by 5‐year age groups, sex, and disease stage (AD dementia, prodromal AD, and preclinical AD). Results: The global number of persons with AD dementia, prodromal AD, and preclinical AD were estimated at 32, 69, and 315 million, respectively. Together they constituted 416 million across the AD continuum, or 22% of all persons aged 50 and above. Discussion: Considering predementia stages, the number of persons with AD is much larger than conveyed in available literature. Our estimates are uncertain, especially for predementia stages in low‐ and middle‐income regions where biomarker studies are missing.
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Estimates are emerging of the prevalence of preclinical Alzheimer's disease in the population.
“While this is still the subject of ongoing research, estimates are emerging of the prevalence of preclinical Alzheimer's disease in the population.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [250]
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1 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430 · see citing works
RetractedMcKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30925-9 · Cited by 19,358 · see citing works
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., et al. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00249-8 · Cited by 5,575 · see citing works
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946 · see citing works
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411 · see citing works
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689 · see citing works
Cognitive reserve in ageing and Alzheimer's disease
Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557 · see citing works
Forecasting the global burden of Alzheimer's disease
Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370 · see citing works
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
Nichols, E., Szoeke, C. E. I., Vollset, S. E., Abbasi, N., Abd-Allah, F., Abdela, J., Aichour, M. T. E., Akinyemi, R. O., Alahdab, F., Asgedom, S. W., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30403-4 · Cited by 2,412 · see citing works
2021 Alzheimer's disease facts and figures
Anonymous (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12328 · Cited by 2,235 · see citing works
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
The Mini-Cog: a cognitive ?vital signs? measure for dementia screening in multi-lingual elderly
Soo Borson, B., Scanlan, J. M., Brush, M. B., VITALIANO, P. P., & Dokmak, A. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/1099-1166(200011)15:11 · Cited by 1,792 · see citing works
Alzheimer’s disease drug-development pipeline: Few candidates, frequent failures
Cummings, J. L., Morstorf, T., & Zhong, K. (2014) · Alzheimer's Research & Therapy · doi:10.1186/alzrt269 · Cited by 1,744 · see citing works
Family caregivers of people with dementia
Brodaty, H., & Donkin, M. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.2/hbrodaty · Cited by 1,644 · see citing works
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610 · see citing works
The worldwide costs of dementia 2015 and comparisons with 2010
Wimo, A., Guerchet, M., Ali, G., Wu, Y., Prina, A. M., Winblad, B., Jönsson, L., Liu, Z., & Prince, M. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.07.150 · Cited by 1,066 · see citing works
Sex differences in Alzheimer disease — the gateway to precision medicine
for the Women’s Brain Project and the Alzheimer Precision Medicine Initiative, Ferretti, M. T., Iulita, M. F., Cavedo, E., Chiesa, P. A., Schumacher Dimech, A., Santuccione Chadha, A., Baracchi, F., Girouard, H., Misoch, S., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0032-9 · Cited by 1,009 · see citing works
Self-citationUnderstanding the impact of sex and gender in Alzheimer’s disease: A call to action
Nebel, R. A., Aggarwal, N. T., Barnes, L. L., Gallagher, A., Goldstein, J. M., Kantarci, K., Mallampalli, M. P., Mormino, E. C., Scott, L., Yu, W. H., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.04.008 · Cited by 839 · see citing works
Hansson, O., Seibyl, J., Stomrud, E., Zetterberg, H., Trojanowski, J. Q., Bittner, T., Lifke, V., Corradini, V., Eichenlaub, U., Batrla, R., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.01.010 · Cited by 808 · see citing works
Ott, A., Breteler, M. M. B., van Harskamp, F., Claus, J. J., van der Cammen, T. J. M., Grobbee, D. E., & Hofman, A. (1995) · BMJ · doi:10.1136/bmj.310.6985.970 · Cited by 792 · see citing works
Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis
Ossenkoppele, R., Jansen, W. J., Rabinovici, G. D., Knol, D. L., van der Flier, W. M., van Berckel, B. N. M., Scheltens, P., Visser, P. J., Verfaillie, S. C. J., Zwan, M. D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4669 · Cited by 677 · see citing works
A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward
Belloy, M. E., Napolioni, V., & Greicius, M. D. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.056 · Cited by 570 · see citing works
Vermunt, L., Sikkes, S. A. M., van den Hout, A., Handels, R., Bos, I., van der Flier, W. M., Kern, S., Ousset, P., Maruff, P., Skoog, I., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.04.001 · Cited by 570 · see citing works
Alzheimer's disease drug development pipeline: 2017
Cummings, J., Lee, G., Mortsdorf, T., Ritter, A., & Zhong, K. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.05.002 · Cited by 549 · see citing works
Alzheimer’s disease drug development pipeline: 2021
Cummings, J., Lee, G., Zhong, K., Fonseca, J., & Taghva, K. (2021) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12179 · Cited by 539 · see citing works
Gender and incidence of dementia in the Framingham Heart Study from mid‐adult life
Chêne, G., Beiser, A., Au, R., Preis, S. R., Wolf, P. A., Dufouil, C., & Seshadri, S. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.10.005 · Cited by 499 · see citing works
The Prevalence of Dementia: A Systematic Review and Meta-Analysis
Cao, Q., Tan, C.-C., Xu, W., Hu, H., Cao, X.-P., Dong, Q., Tan, L., & Yu, J.-T. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-191092 · Cited by 446 · see citing works
Systematic review of dementia prevalence and incidence in United States race/ethnic populations
Mehta, K. M., & Yeo, G. W. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.06.2360 · Cited by 439 · see citing works
Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis
Hendriks, S., Peetoom, K., Bakker, C., van der Flier, W. M., Papma, J. M., Koopmans, R., Verhey, F. R. J., de Vugt, M., Köhler, S., Young-Onset Dementia Epidemiology Study Group, et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.2161 · Cited by 409 · see citing works
Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States
Brookmeyer, R., Abdalla, N., Kawas, C. H., & Corrada, M. M. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.10.009 · Cited by 406 · see citing works
National estimates of the prevalence of Alzheimer's disease in the United States
Brookmeyer, R., Evans, D. A., Hebert, L. E., Langa, K. M., Heeringa, S. G., Plassman, B. L., & Kukull, W. A. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.11.007 · Cited by 402 · see citing works
Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage
Vos, S. J. B., Verhey, F., Frölich, L., Kornhuber, J., Wiltfang, J., Maier, W., Peters, O., Rüther, E., Nobili, F., Morbelli, S., et al. (2015) · Brain · doi:10.1093/brain/awv029 · Cited by 383 · see citing works
Self-citationAPOE distribution in world populations with new data from India and the UK
Singh, P. P., Singh, M., & Mastana, S. S. (2006) · Annals of Human Biology · doi:10.1080/03014460600594513 · Cited by 351 · see citing works
Sex differences in the association between AD biomarkers and cognitive decline
Initiative, F. T. A. N., Koran, M. E. I., Wagener, M., & Hohman, T. J. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9523-8 · Cited by 339 · see citing works
Jack, C. R., Therneau, T. M., Weigand, S. D., Wiste, H. J., Knopman, D. S., Vemuri, P., Lowe, V. J., Mielke, M. M., Roberts, R. O., Machulda, M. M., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1971 · Cited by 300 · see citing works
Fiest, K. M., Roberts, J. I., Maxwell, C. J., Hogan, D. B., Smith, E. E., Frolkis, A. D., Cohen, A., Kirk, A., Pearson, D. M., Pringsheim, T. M., et al. (2016) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2016.36 · Cited by 270 · see citing works
Racial and ethnic differences in trends in dementia prevalence and risk factors in the United States
Chen, C., & Zissimopoulos, J. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.08.009 · Cited by 265 · see citing works
Parnetti, L., Chipi, E., Salvadori, N., D’Andrea, K., & Eusebi, P. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0459-7 · Cited by 194 · see citing works
Brookmeyer, R., & Abdalla, N. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.03.005 · Cited by 176 · see citing works
Ferretti, M. T., Martínková, J., Biskup, E. M., Benke, T., Gialdini, G., Nedelská, Z., Rauen, K., Mantua, V., Religa, D., Hort, J., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14174 · Cited by 150 · see citing works
Self-citationEducation and the Risk of Alzheimer's Disease: Findings From the Study of Dementia in Swedish Twins
Gatz, M., Svedberg, P., Pedersen, N. L., Mortimer, J. A., Berg, S., & Johansson, B. E. A. (2001) · The Journals of Gerontology Series B · doi:10.1093/geronb/56.5.p292 · Cited by 142 · see citing works
Bacigalupo, I., Mayer, F., Lacorte, E., Pucchio, A. D., Marzolini, F., Canevelli, M., Fiandra, T. D., & Vanacore, N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180416 · Cited by 141 · see citing works
Hlávka, J. P., Mattke, S., & Liu, J. (2018) · RAND Corporation eBooks · doi:10.7249/rr2503 · Cited by 134 · see citing works
Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline
Buckley, R. F., Scott, M. R., Jacobs, H. I. L., Schultz, A. P., Properzi, M. J., Amariglio, R. E., Hohman, T. J., Mayblyum, D. V., Rubinstein, Z. B., Manning, L. K., et al. (2020) · Annals of Neurology · doi:10.1002/ana.25878 · Cited by 132 · see citing works
The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects
Smith, R. A., Strandberg, O. T., Mattsson, N., Leuzy, A., Palmqvist, S., Pontecorvo, M. J., Devous, M. D., Ossenkoppele, R., & Hansson, O. (2020) · Brain · doi:10.1093/brain/awaa327 · Cited by 132 · see citing works
Prevalence of preclinical Alzheimer disease
Kern, S., Zetterberg, H., Kern, J., Zettergren, A., Wærn, M., Höglund, K., Andréasson, U., Wetterberg, H., Börjesson‐Hanson, A., Blennow, K., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005476 · Cited by 120 · see citing works
Liu, J., Hlavka, J., Hillestad, R., & Mattke, S. (2017) · doi:10.7249/rr2272 · Cited by 98 · see citing works
Prevalence of cerebral amyloid pathology in persons without dementia: A meta-analysis
Jansen, W., Ossenkoppele, R., Knol, D., Tijms, B., Scheltens, P., Fr, V., Visser, P. J., Amyloid Biomarker Study Group, Aalten, P., Aarsland, D., et al. (2015) · Archive ouverte UNIGE (University of Geneva) · Cited by 94 · see citing works
Adelman, S., Blanchard, M., Rait, G., Leavey, G., & Livingston, G. (2011) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086405 · Cited by 87 · see citing works
Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease
Aisen, P. S. S., Vellas, B. J., & Hampel, H. J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3842-c1 · Cited by 76 · see citing works
Anderson, T. S., Ayanian, J. Z., Souza, J., & Landon, B. E. (2021) · JAMA · doi:10.1001/jama.2021.15286 · Cited by 66 · see citing works
Lim, U., Wang, S., Park, S., Bogumil, D. D., Wu, A. H., Cheng, I. C., Haiman, C. A., Marchand, L. L., Wilkens, L. R., White, L. R., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12528 · Cited by 63 · see citing works
Yuan, J., Maserejian, N. N., Liu, Y., Devine, S., Gillis, C., Massaro, J. M., & Au, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200786 · Cited by 46 · see citing works
Emergence and progress of white matter lesion in brain check-up
Masana, Y., & Motozaki, T. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.02021.x · Cited by 40 · see citing works
Rossini, P. M., Cappa, S. F., Lattanzio, F., Perani, D., Spadin, P., Tagliavini, F., & Vanacore, N. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190670 · Cited by 36 · see citing works
Self-citation
Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- American Psychiatric Association, Diagnostic and statistical manual of mental disorders. 2000(4th edition).
- Jonker C, Geerlings MI, Schmand B. Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry. 2000;15(11):983-991.
Cited by
Sorted by citations
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(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212 · see citing works
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(2025) · Alzheimer s & Dementia · doi:10.1002/alz.70235 · Cited by 569 · see citing works
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Cummings, J., Zhou, Y., Lee, G., Zhong, K., Fonseca, J., & Cheng, F. (2023) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12385 · Cited by 477 · see citing works
The NLRP3 inflammasome: contributions to inflammation-related diseases
Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., Jing, T., Yao, Y., Qiu, Z., Wang, Z., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00462-9 · Cited by 492 · see citing works
Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation
Dubois, B., Villain, N., Schneider, L., Fox, N., Campbell, N., Galasko, D., Kivipelto, M., Jessen, F., Hanseeuw, B., Boada, M., et al. (2024) · JAMA Neurology · doi:10.1001/jamaneurol.2024.3770 · Cited by 426 · see citing works
Self-citationTowards a future where Alzheimer’s disease pathology is stopped before the onset of dementia
van der Flier, W. M., de Vugt, M. E., Smets, E. M. A., Blom, M., & Teunissen, C. E. (2023) · Nature Aging · doi:10.1038/s43587-023-00404-2 · Cited by 220 · see citing works
Vucic, S., Chen, K.-H. S., Kiernan, M. C., Hallett, M., Benninger, D. H., Lazzaro, V. D., Rossini, P. M., Benussi, A., Berardelli, A., Currà, A., et al. (2023) · Clinical Neurophysiology · doi:10.1016/j.clinph.2023.03.010 · Cited by 226 · see citing works
Self-citationNimgampalle, M., Chakravarthy, H., Sharma, S., Shree, S., Bhat, A. R., Pradeepkiran, J. A., & Devanathan, V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101994 · Cited by 207 · see citing works
Cell type‐specific roles of APOE4 in Alzheimer disease
Blumenfeld, J., Yip, O., Kim, M. J., & Huang, Y. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00776-9 · Cited by 202 · see citing works
Frisoni, G. B., Altomare, D., Ribaldi, F., Villain, N., Brayne, C., Mukadam, N., Abramowicz, M. J., Barkhof, F., Berthier, M. L., Bieler-Aeschlimann, M., et al. (2023) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2022.100576 · Cited by 187 · see citing works
Self-citationLanctôt, K. L., Hahn‐Pedersen, J. H., Eichinger, C. S., Freeman, C. S., Clark, A., Tarazona, L. R. S., & Cummings, J. L. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.61 · Cited by 159 · see citing works
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Moguilner, S., Baez, S., Hernandez, H., Migeot, J., Legaz, A., Gonzalez-Gomez, R., Farina, F. R., Prado, P., Cuadros, J., Tagliazucchi, E., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03209-x · Cited by 128 · see citing works
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Hossain, M. S., & Hussain, M. H. (2025) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70131 · Cited by 94 · see citing works
Hu, Z., Chen, P.-H., Li, W., Douglas, T., Hines, J., Liu, Y., & Crews, C. M. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c11706 · Cited by 98 · see citing works
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Sex and gender considerations in Alzheimer’s disease: The Women’s Brain Project contribution
Castro‐Aldrete, L., Moser, M. V., Putignano, G., Ferretti, M. T., Dimech, A. S., & Chadha, A. S. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1105620 · Cited by 82 · see citing works
Self-citationGliwińska, A., Czubilińska-Łada, J., Więckiewicz, G., Świętochowska, E., Badeński, A., Dworak, M., & Szczepańska, M. (2023) · Brain Sciences · doi:10.3390/brainsci13020163 · Cited by 78 · see citing works
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Pradeepkiran, J. A., Baig, J., Islam, M. A., Kshirsagar, S., & Reddy, P. H. (2024) · Aging and Disease · doi:10.14336/ad.2024.0286 · Cited by 81 · see citing works
Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding
Grant, W. B., & Blake, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230418 · Cited by 73 · see citing works
Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction
Wang, H., Nery, E. S. M., Ardayfio, P. A., Khanna, R., Svaldi, D. O., Gueorguieva, I., Shcherbinin, S., Andersen, S. W., Hauck, P. M., Engle, S. E., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70062 · Cited by 75 · see citing works
Pei, J., Kumarasamy, R. V., Jayaraman, S., Kanniappan, G. V., Long, Q., & Palanisamy, C. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102665 · Cited by 66 · see citing works
Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology
Paoletti, I., & Coccurello, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413480 · Cited by 70 · see citing works
Butler, P. M., Yang, J. F., Brown, R. Z., Hobbs, M., Becker, A., Penalver-Andres, J. A., Syz, P., Muller, S., Cosne, G., Juraver, A., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03475-9 · Cited by 66 · see citing works
Nanomedicine in the Management of Alzheimer’s Disease: State-of-the-Art
Ullah, S. N. M. N., Afzal, O., Altamimi, A. S. A., Ather, H., Sultana, S., Almalki, W. H., Bharti, P., Sahoo, A., Dwivedi, K., Khan, G., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061752 · Cited by 61 · see citing works
Zou, D., Liu, R., Lv, Y., Guo, J., Zhang, C., & Xie, Y. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2270781 · Cited by 60 · see citing works
Hydrogen sulfide signalling in neurodegenerative diseases
Tripathi, S. J., Chakraborty, S., Miller, E., Pieper, A. A., & Paul, B. D. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16170 · Cited by 59 · see citing works
Effect of renal function on the diagnostic performance of plasma biomarkers for Alzheimer’s disease
Zhang, B., Zhang, C., Wang, Y., Chen, L., Qiao, Y., Wang, Y., Peng, D., & Initiative, A. D. N. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1150510 · Cited by 58 · see citing works
AI-powered integration of multimodal imaging in precision medicine for neuropsychiatric disorders
Huang, W., & Shu, N. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102132 · Cited by 58 · see citing works
Zhao, Y., Jia, M., Ding, C., Bao, B., Li, H., Ma, J., Dong, W., Gao, R., Chen, X., Chen, J., et al. (2025) · iMeta · doi:10.1002/imt2.70006 · Cited by 57 · see citing works
Ossenkoppele, R., Coomans, E. M., Apostolova, L. G., Baker, S. L., Barthel, H., Beach, T. G., Benzinger, T. L. S., Betthauser, T. J., Bischof, G. N., Bottlaender, M., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02000-6 · Cited by 56 · see citing works
Incidence and prevalence of Alzheimer’s disease in China: a systematic review and meta-analysis
Ji, Q., Chen, J., Li, Y., Tao, E., & Zhan, Y. (2024) · European Journal of Epidemiology · doi:10.1007/s10654-024-01144-2 · Cited by 53 · see citing works
Music Engagement as a Source of Cognitive Reserve
Wolff, L., Quan, Y., Perry, G., & Thompson, W. F. (2023) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175231214833 · Cited by 53 · see citing works
Prevalence of Alzheimer’s disease pathology in the community
Aarsland, D., Sunde, A. L., Tovar, D., Leuzy, A., Fladby, T., Zetterberg, H., Blennow, K., Tan, K., Santis, G. D., Yakoub, Y., et al. (2025) · Nature · doi:10.1038/s41586-025-09841-y · Cited by 51 · see citing works
van Gils, V., Rizzo, M., Côté, J., Viechtbauer, W., Fanelli, G., Salas‐Salvadó, J., Wimberley, T., Bulló, M., Fernández‐Aranda, F., Dalsgaard, S., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105604 · Cited by 50 · see citing works
The ATN Framework—Moving Preclinical Alzheimer Disease to Clinical Relevance
van der Flier, W. M., & Scheltens, P. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.2967 · Cited by 49 · see citing works
Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches
Gholami, A. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137532 · Cited by 51 · see citing works
Zhao, Z., Liu, Y., Ruan, S., & Hu, Y. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s444115 · Cited by 49 · see citing works
The Role of IL-6 in Neurodegenerative Disorders
Shan, C., Zhang, C., & Zhang, C. (2024) · Neurochemical Research · doi:10.1007/s11064-023-04085-6 · Cited by 49 · see citing works
The evolving landscape of Alzheimer’s disease therapy: From Aβ to tau
Courade, J., Zetterberg, H., Höglinger, G. U., & Dewachter, I. (2025) · Cell · doi:10.1016/j.cell.2025.11.033 · Cited by 52 · see citing works
The role of the CD8+ T cell compartment in ageing and neurodegenerative disorders
Terrabuio, E., Zenaro, E., & Constantin, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1233870 · Cited by 48 · see citing works
A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
Lu, C., Meng, C., Li, Y., Yuan, J., Ren, X., Gao, L., Su, D., Cao, K., Cui, M., Yuan, Q., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49409-4 · Cited by 47 · see citing works
Manser, P., Herold, F., & de Bruin, E. D. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102385 · Cited by 52 · see citing works
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease
Bano, N., Khan, S., Ahamad, S., Kanshana, J. S., Dar, N. J., Khan, S. J., Nazir, A., & Bhat, S. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102515 · Cited by 49 · see citing works
Engineered Exosomes as Smart Drug Carriers: Overcoming Biological Barriers in CNS and Cancer Therapy
Premchandani, T., Tatode, A., Taksande, J., Umekar, M. J., Qutub, M., Hussain, U., & Singanwad, P. (2025) · Drugs and Drug Candidates · doi:10.3390/ddc4020019 · Cited by 48 · see citing works
Zhang, Y., Liu, S., Cao, D., Zhao, M., Lu, H., & Wang, P. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119285 · Cited by 46 · see citing works
Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease
Gong, Y., Haeri, M., Zhang, X., Li, Y., Liu, A., Wu, D., Zhang, Q., Jazwinski, S. M., Zhou, X., Wang, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54715-y · Cited by 51 · see citing works
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored
Kapoor, B., Biswas, P., Gulati, M., Rani, P., & Gupta, R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102570 · Cited by 46 · see citing works
Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis
Coradduzza, D., Sedda, S., Cruciani, S., Miglio, M. R. D., Ventura, C., Nivoli, A., & Maioli, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813680 · Cited by 44 · see citing works
Jung, Y. H., Chae, C. W., & Han, H. J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01282-3 · Cited by 42 · see citing works
Advancements in the Application of Nanomedicine in Alzheimer’s Disease: A Therapeutic Perspective
Puranik, N., Yadav, D., & Song, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814044 · Cited by 44 · see citing works
Newer Therapeutic Approaches in Treating Alzheimer’s Disease: A Comprehensive Review
Sree, R. R., Kalyan, M., Anand, N., Mani, S., Gorantla, V. R., Sakharkar, M. K., Song, B., & Chidambaram, S. B. (2025) · ACS Omega · doi:10.1021/acsomega.4c05527 · Cited by 45 · see citing works
Olfactory deficit: a potential functional marker across the Alzheimer’s disease continuum
Liu, D., Lu, J., Wei, L., Yao, M., Yang, H., Lv, P., Wang, H., Zhu, Y., Zhu, Z., Zhang, X., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1309482 · Cited by 40 · see citing works
Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease
Lin, M., Yu, J., Zhang, W., Lao, F., & Huang, H. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.164 · Cited by 41 · see citing works
Abbas, K., Mustafa, M., Alam, M., Habib, S., Ahmad, W., Adnan, M., Hassan, M. I., & Usmani, N. (2025) · Neurogenetics · doi:10.1007/s10048-025-00821-y · Cited by 43 · see citing works
2026 Alzheimer's disease facts and figures
(2026) · Alzheimer s & Dementia · doi:10.1002/alz.71345 · Cited by 61 · see citing works
Villain, N., & Michalon, R. (2024) · European Journal of Neurology · doi:10.1111/ene.16302 · Cited by 39 · see citing works
The vascular contribution of apolipoprotein E to Alzheimer’s disease
Chen, F., Zhao, J., Meng, F., He, F., Ni, J., & Fu, Y. (2024) · Brain · doi:10.1093/brain/awae156 · Cited by 38 · see citing works
Alzheimer disease seen through the lens of sex and gender
Castro‐Aldrete, L., Einsiedler, M., Martínková, J., Depypere, H. T., Ang, T. F. A., Mielke, M. M., Sindi, S., Eyre, H. A., Au, R., Dimech, A. S., et al. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01071-0 · Cited by 39 · see citing works
Self-citationCostanzo, M., Cutrona, C., Leodori, G., Malimpensa, L., D’Antonio, F., Conte, A., & Belvisi, D. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01607-4 · Cited by 39 · see citing works
Yekeler, H. B., Güler, E., Beato, P. S., Priya, S., Abobakr, F. K. M., Doğan, M., Üner, B., Kalaskar, D. M., & Çam, M. E. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131841 · Cited by 35 · see citing works
Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases
Yang, H., Tan, H., Wen, H., Xin, P., Liu, Y., Deng, Z., Xu, Y., Gao, F., Zhang, L., Ye, Z., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c11966 · Cited by 37 · see citing works
Association between migraine and Alzheimer’s disease: a nationwide cohort study
Kim, J., Ha, W., Park, S. H., Han, K., & Baek, M. S. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1196185 · Cited by 34 · see citing works
Jarek, D. J., Mizerka, H., Nuszkiewicz, J., & Szewczyk‐Golec, K. (2024) · Biomedicines · doi:10.3390/biomedicines12040786 · Cited by 34 · see citing works
Sullivan, A. C., Zuniga, G., Ramirez, P., Fernandez, R. A., Wang, C., Li, J., Davila, L., Pelton, K., Gomez, S., Sohn, C., et al. (2025) · npj Dementia · doi:10.1038/s44400-024-00001-z · Cited by 33 · see citing works
Yang, C., Sun, J., Li, L., Zheng, J. H., Wang, C., Zhao, Y., Yun, D., Jia, M., Wu, Z., Liang, H., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70406 · Cited by 38 · see citing works
Liu, A., Fernandes, B. S., Citu, C., & Zhao, Z. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01372-w · Cited by 34 · see citing works
Agnello, L., Gambino, C. M., Ciaccio, A. M., Masucci, A., Vassallo, R., Tamburello, M., Scazzone, C., Sasso, B. L., & Ciaccio, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084323 · Cited by 37 · see citing works
Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer’s Disease
Jeong, S. P., Sharma, N., & An, S. S. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094806 · Cited by 33 · see citing works
Zülke, A. E., Pabst, A., Luppa, M., Oey, A., Weise, S., Fankhänel, T., Kosilek, R. P., Schillok, H., Brettschneider, C., Czock, D., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14097 · Cited by 32 · see citing works
Alzheimer’s Disease and Porphyromonas gingivalis: Exploring the Links
Shawkatová, I., Ďurmanová, V., & Javor, J. (2025) · Life · doi:10.3390/life15010096 · Cited by 34 · see citing works
Dumas, A., Destrebecq, F., Esposito, G., Suchoňová, D., & Frederiksen, K. S. (2023) · Aging Brain · doi:10.1016/j.nbas.2023.100093 · Cited by 31 · see citing works
Nanotechnology in the diagnostic and therapy for Alzheimer's disease
Panghal, A., & Flora, S. J. S. (2024) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2024.130559 · Cited by 31 · see citing works
Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders
Barrantes, F. J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1476909 · Cited by 31 · see citing works
Zheng, J., Jiang, X., Bai, S., Lai, M., Yu, J., Chen, M., Zhou, R., Jia, Y., Yan, H., Liang, Z., et al. (2025) · Advanced Materials · doi:10.1002/adma.202505262 · Cited by 31 · see citing works
Nemergut, M., Marques, S. M., Uhrik, L., Vanova, T., Nezvedova, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00620-9 · Cited by 30 · see citing works
Mattke, S., Gustavsson, A., Jacobs, L., Kern, S., Palmqvist, S., Eriksdotter, M., Skoog, I. G., Winblad, B. G., Wimo, A. B., & Jönsson, L. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.94 · Cited by 29 · see citing works
Self-citationElucidating the Role of Lipids in the Aggregation of Amyloidogenic Proteins
Kurouski, D. (2023) · Accounts of Chemical Research · doi:10.1021/acs.accounts.3c00386 · Cited by 30 · see citing works
Snellman, A., Ekblad, L. L., Tuisku, J., Koivumäki, M., Ashton, N. J., Lantero‐Rodriguez, J., Karikari, T. K., Helin, S., Bucci, M., Löyttyniemi, E., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01209-6 · Cited by 30 · see citing works
Calderón‐Garcidueñas, L., Hernández-Luna, J., Aiello-Mora, M., Brito-Aguilar, R., Evelson, P., Villarreal-Ríos, R., Torres‐Jardón, R., Ayala, A., & Mukherjee, P. S. (2023) · Biomolecules · doi:10.3390/biom13060927 · Cited by 28 · see citing works
Weaver, D. F. (2023) · Brain Sciences · doi:10.3390/brainsci14010041 · Cited by 31 · see citing works
van der Veere, P. J., Hoogland, J., Visser, L. N. C., van Harten, A. C., Rhodius‐Meester, H. F. M., Sikkes, S. A. M., Venkatraghavan, V., Barkhof, F., Teunissen, C. E., van de Giessen, E., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000209605 · Cited by 29 · see citing works
Terrabuio, E., Pietronigro, E. C., Bani, A., Bianca, V. D., Laudanna, C., Rossi, B., Finotti, G., Santos-Lima, B., Zenaro, E., Turano, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62405-6 · Cited by 29 · see citing works
Vielee, S. T., & Wise, J. P. (2023) · Brain Sciences · doi:10.3390/brainsci13030500 · Cited by 29 · see citing works
Yao, Q., Jiang, K., Lin, F., Zhu, T., Khan, N. H., & Jiang, E. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s400527 · Cited by 29 · see citing works
Crowell, V., Reyes, A., Zhou, S. Q., Vassilaki, M. E., Gsteiger, S., & Gustavsson, A. (2023) · BMC Neurology · doi:10.1186/s12883-023-03353-w · Cited by 28 · see citing works
Self-citationMicroglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease
Hou, Y., Caldwell, J., Lathia, J. D., Leverenz, J. B., Pieper, A. A., Cummings, J. L., & Cheng, F. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13546 · Cited by 27 · see citing works
Sun, J., Li, L., Li, X., Chen, F., She, L., Tang, H., Zeng, Y., Duan, Y., Li, L., Wang, W., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115909 · Cited by 28 · see citing works
RetractedZhu, Y., Li, L., Jin, X., Li, Z., Wang, C., Teng, L., Li, Y., Zhang, Y., & Wang, D. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128819 · Cited by 28 · see citing works
Nassar, A., Satarker, S., Gurram, P. C., Upadhya, D., Fayaz, S., & Nampoothiri, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03437-1 · Cited by 27 · see citing works
A Literature Review on the Burden of Alzheimer’s Disease on Care Partners
Frederiksen, K. S., Lanctôt, K. L., Weidner, W. S., Hahn‐Pedersen, J. H., & Mattke, S. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230487 · Cited by 29 · see citing works
Contador, I., Buch-Vicente, B., del Ser, T., Velasco, S. L., Villarejo‐Galende, A., Benito‐León, J., & Bermejo‐Pareja, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144100 · Cited by 30 · see citing works
Sattarov, R., Havers, M., Orbjörn, C., Stomrud, E., Janelidze, S., Laurell, T., & Mattsson, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-75406-0 · Cited by 27 · see citing works
Altered T-cell reactivity in the early stages of Alzheimer's disease
Rickenbach, C., Mallone, A., Häusle, L., Frei, L., Seiter, S., Sparano, C., Kirabali, T., Blennow, K., Zetterberg, H., Ferretti, M. T., et al. (2025) · Brain · doi:10.1093/brain/awaf167 · Cited by 27 · see citing works
Self-citationRavichandran, S., Snyder, P. J., Alber, J., Murchison, C., Chaby, L. E., Jeromin, A., & Arthur, E. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01668-5 · Cited by 26 · see citing works
- Authors
- Gustavsson, A., Norton, N., Fast, T., Frölich, L., Georges, J., Holzapfel, D., Kirabali, T., Krolak‐Salmon, P., Rossini, P. M., Ferretti, M. T., Lanman, L., Chadha, A. S., & van der Flier, W. M.
- Affiliations
- Karolinska Institutet (SE)
- Quantify Research (Sweden) (SE)
- Heidelberg University (DE)
- Alzheimer Europe (LU)
- CEO Initiative on Alzheimer's Disease Philadelphia USA
- Biogen (Switzerland) (CH)
- Hospices Civils de Lyon (FR)
- Università Cattolica del Sacro Cuore (IT)
- Women's Brain Project (CH)
- F. Hoffmann-La Roche AG (CH)
- Alzheimer Center Amsterdam Department of Neurology Department of Epidemiology and Data Science Amsterdam Neuroscience Amsterdam UMC, Vrije Universiteit Amsterdam Amsterdam the Netherlands
- Corresponding author
- Gustavsson, Anders
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2022-06-02
- Volume
- 19
- Issue
- 2
- Pages
- 658-670
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W4281674975
- Cited by
- 895
- References
- 62
- Citations by year
- 2026: 207 · 2025: 323 · 2024: 236 · 2023: 114 · 2022: 15
- FWCI
- 112.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- F. Hoffmann-La Roche
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, Alzheimer's disease continuum
- MeSH terms
- Alzheimer Disease, Humans, Biomarkers, Prevalence, Prodromal Symptoms
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