The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Effect of Surface Charge on the Cellular Uptake and Cytotoxicity of Fluorescent Labeled Cellulose Nanocrystals
Open accessAbstract
Probing of cellular uptake and cytotoxicity was conducted for two fluorescent cellulose nanocrystals (CNCs): CNC-fluorescein isothiocyanate (FITC) and newly synthesized CNC-rhodamine B isothiocyanate (RBITC). The positively charged CNC-RBITC was uptaken by human embryonic kidney 293 (HEK 293) and Spodoptera frugiperda (Sf9) cells without affecting the cell membrane integrity. The cell viability assay and cell-based impedance spectroscopy revealed no noticeably cytotoxic effect of the CNC-RBITC conjugate. However, no significant internalization of negatively charged CNC-FITC was observed at physiological pH. Indeed, the effector cells were surrounded by CNC-FITC, leading to eventual cell rupture. As the surface charge of CNC played an important role in cellular uptake and cytotoxicity, facile surface functionalization together with observed noncytotoxicity rendered modified CNC as a promising candidate for bioimaging and drug delivery systems.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., & Walter, P. (2017) · W.W. Norton eBooks · doi:10.1201/9781315735368 · Cited by 6,365
Cellulose nanocrystals: chemistry, self-assembly, and applications
Habibi, Y., Lucia, L. A., & Rojas, O. J. (2010) · Chemical Reviews · doi:10.1021/cr900339w · Cited by 5,980
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
OWENSIII, D., & PEPPAS, N. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.010 · Cited by 3,637
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
Dubertret, B., Skourides, P., Norris, D. J., Noireaux, V., Brivanlou, A. H., & Libchaber, A. (2002) · Science · doi:10.1126/science.1077194 · Cited by 3,019
Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805135105 · Cited by 2,823
Mesoporous Materials for Drug Delivery
Vallet‐Regí, M., Balas, F., & Arcos, D. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604488 · Cited by 2,507
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
Panyam, J., Zhou, W., Prabha, S., Sahoo, S. K., & Labhasetwar, V. (2002) · The FASEB Journal · doi:10.1096/fj.02-0088com · Cited by 1,044
Study on antimicrobial activity of chitosan with different molecular weights
Zheng, L.-Y., & Zhu, J.-F. (2003) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2003.07.009 · Cited by 1,030
Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers
Hong, R., Han, G., Fernández, J. M., Kim, B.-J., Forbes, N. S., & Rotello, V. M. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056726i · Cited by 817
Cited by
Production of nanocrystalline cellulose from lignocellulosic biomass: Technology and applications
Brinchi, L., Cotana, F., Fortunati, E., & Kenny, J. M. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.01.033 · Cited by 1,121
Current characterization methods for cellulose nanomaterials
Foster, E. J., Moon, R. J., Agarwal, U. P., Bortner, M. J., Bras, J., Camarero-Espinosa, S., Chan, K. J., Clift, M. J. D., Cranston, E. D., Eichhorn, S. J., et al. (2018) · Chemical Society Reviews · doi:10.1039/c6cs00895j · Cited by 1,021
Klemm, D., Cranston, E. D., Fischer, D., Gama, M., Kedzior, S. A., Kralisch, D., Kramer, F., Kondo, T., Lindström, T., Nietzsche, S., et al. (2018) · Materials Today · doi:10.1016/j.mattod.2018.02.001 · Cited by 936
Nanocrystals: a perspective on translational research and clinical studies
Jarvis, M., Krishnan, V., & Mitragotri, S. (2019) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10122 · Cited by 162
Metadata
- Authors
- Mahmoud, K. A., Mena, J. A., Male, K. B., Hrapovic, S., Kamen, A., & Luong, J. H. T.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-10-04
- Volume
- 2
- Issue
- 10
- Pages
- 2924-2932
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2318683722
- Cited by
- 316
- References
- 34
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of Surface Charge on the Cellular Uptake and Cytotoxicity of Fluorescent Labeled Cellulose Nanocrystals. https://app.cochat.ai/papers/10.1021/am1006222
- The paper
- Mahmoud, K. A., Mena, J. A., Male, K. B., Hrapovic, S., Kamen, A., & Luong, J. H. T. (2010). Effect of Surface Charge on the Cellular Uptake and Cytotoxicity of Fluorescent Labeled Cellulose Nanocrystals. ACS Applied Materials & Interfaces. https://doi.org/10.1021/am1006222
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
