The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Electrospun Bio-Nanocomposite Scaffolds for Bone Tissue Engineering by Cellulose Nanocrystals Reinforcing Maleic Anhydride Grafted PLA
Abstract
Electrospun fibrous bio-nanocomposite scaffolds reinforced with cellulose nanocrystals (CNCs) were fabricated by using maleic anhydride (MAH) grafted poly(lactic acid) (PLA) as matrix with improved interfacial adhesion between the two components. Morphological, thermal, mechanical, and in vitro degradation properties as well as basic cytocompatibility using human adult adipose derived mesenchymal stem cells (hASCs) of MAH grafted PLA/CNC (i.e., MPLA/CNC) scaffolds were characterized. Morphological investigation indicated that the diameter and polydispersity of electrospun MPLA/CNC nanofibers were reduced with the increased CNC content. The addition of CNCs improved both the thermal stability and mechanical properties of MPLA/CNC composites. The MPLA/CNC scaffolds at the 5 wt % CNC loading level showed not only superior tensile strength (more than 10 MPa), but also improved stability during in vitro degradation compared with the MPLA and PLA/CNC counterparts. Moreover, the fibrous MPLA/CNC composite scaffolds were non-toxic to hASCs and capable of supporting cell proliferation. This study demonstrates that fibrous MPLA/CNC bio-nanocomposite scaffolds are biodegradable, cytocompatible, and possess useful mechanical properties for bone tissue engineering.
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Cites
Cellulose nanomaterials review: structure, properties and nanocomposites
Moon, R. J., Martini, A., Nairn, J., Simonsen, J., & Youngblood, J. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00108b · Cited by 6,756
Cellulose nanocrystals: chemistry, self-assembly, and applications
Habibi, Y., Lucia, L. A., & Rojas, O. J. (2010) · Chemical Reviews · doi:10.1021/cr900339w · Cited by 5,980
Poly(lactic acid) modifications
Rasal, R. M., Janorkar, A. V., & Hirt, D. E. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.12.003 · Cited by 2,204
Poly(lactic acid) fiber: An overview
Gupta, B., Revagade, N., & Hilborn, J. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.01.005 · Cited by 1,360
Cited by
Bone biomaterials and interactions with stem cells
Gao, C., Peng, S., Feng, P., & Shuai, C. (2017) · Bone Research · doi:10.1038/boneres.2017.59 · Cited by 720
Cellulose Nanoparticles as Modifiers for Rheology and Fluid Loss in Bentonite Water-based Fluids
Li, M.-C., Wu, Q., Song, K., Qing, Y., & Wu, Y. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b00498 · Cited by 373
Self-citationNatural and Synthetic Polymers for Bone Scaffolds Optimization
Donnaloja, F., Jacchetti, E., Soncini, M., & Raimondi, M. T. (2020) · Polymers · doi:10.3390/polym12040905 · Cited by 324
Poly(glycerol sebacate urethane)–cellulose nanocomposites with water-active shape-memory effects
Wu, T., Frydrych, M., O’Kelly, K., & Chen, B. (2014) · Biomacromolecules · doi:10.1021/bm500507z · Cited by 126
Hivechi, A., Bahrami, S. H., Siegel, R. A., Siehr, A., Sahoo, A., Milan, P. B., Joghataei, M. T., Amoupour, M., & Simorgh, S. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111855 · Cited by 38
Metadata
- Authors
- Zhou, C., Shi, Q., Guo, W., Terrell, L., Qureshi, A. T., Hayes, D. J., & Wu, Q.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-16
- Volume
- 5
- Issue
- 9
- Pages
- 3847-3854
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2013213171
- Cited by
- 327
- References
- 4
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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