Cited by 127Polymer composites and self-healingAdvanced Materials and MechanicsHydrogels: synthesis, properties, applications

Poly(glycerol sebacate urethane)–cellulose nanocomposites with water-active shape-memory effects

Wu, Tongfei, Frydrych, Martin, O’Kelly, Kevin, Chen, Biqiong·2014·Biomacromolecules

Abstract

Biodegradable and biocompatible materials with shape-memory effects (SMEs) are attractive for use as minimally invasive medical devices. Nanocomposites with SMEs were prepared from biodegradable poly(glycerol sebacate urethane) (PGSU) and renewable cellulose nanocrystals (CNCs). The effects of CNC content on the structure, water absorption, and mechanical properties of the PGSU were studied. The water-responsive mechanically adaptive properties and shape-memory performance of PGSU-CNC nanocomposites were observed, which are dependent on the content of CNCs. The PGSU-CNC nanocomposite containing 23.2 vol % CNCs exhibited the best SMEs among the nanocomposites investigated, with the stable shape fixing and shape recovery ratios being 98 and 99%, respectively, attributable to the formation of a hydrophilic, yet strong, CNC network in the elastomeric matrix. In vitro degradation profiles of the nanocomposites were assessed with and without the presence of an enzyme.

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Crossref · 10.1021/bm500507z

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  • The presence of CNCs up to 23 vol% improved PGSU tensile strength and Young's modulus up to 1040% and 4400%, respectively.

    “The presence of CNCs (up to 23 vol%) led to an improvement of the PGSU materials tensile strength and the Young's modulus up to 1040% and 4400%, respectively.”
  • In the PGSU-CNC study, hydrophilic nanocrystals were grafted along the polymer macromolecule via reaction of CNCs with isocyanate groups of hexamethylene diisocyanate to form urethane linkages.

    “In this study the hydrophilic nanocrystals were grafted along the polymer macromolecule: CNCs got competed with the -OH groups from PGS prepolymer (product of glycerol and sebacic acid polycondensation) to react with the isocyanate groups of hexamethylene diisocyanate in order to form urethane linkages.”
  • Water-active shape-memory materials using hydrophilic CNCs as an active agent were prepared using biodegradable poly(glycerol sebacate urethane) (PGSU).

    “hydrophilic CNCs as an active agent, were also prepared using biodegradable poly(glycerol sebacate urethane) (PGSU) [185].”
  • The improvement was explained by formation of strong interfacial hydrogen-bond interactions between CNCs and PGSU in the blend.

    “The phenomena was explained with the formation of strong interfacial interactions based on hydrogen bonds between CNCs and PGSU in the blend.”
  • PGSU-CNC materials were lipase enzymatically degradable, with weight loss of 17% in 28 days.

    “The materials were lipase enzymatically degradable (weight loss of 17% in 28 days)”

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Authors
Wu, T., Frydrych, M., O’Kelly, K., & Chen, B.
Affiliations
  • University of Sheffield (GB)
  • Trinity College Dublin (IE)
Corresponding author
Chen, Biqiong
Venue
Biomacromolecules
Published
2014-06-10
Volume
15
Issue
7
Pages
2663-2671
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2328964456
Cited by
126
References
79
Citations by year
2026: 3 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 14 · 2020: 11 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 8
FWCI
7.45
Type
journal article
Language
en
Open access
closed
Locations
  • Biomacromolecules (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
Funders
  • Royal Society
  • Irish Research Council for Science, Engineering and Technology
Topics
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer composites and self-healing
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
cellulose nanocrystals, shape memory effect, water-responsive materials, biodegradable polymers, nanocomposites, water absorption, mechanical properties, shape recovery ratio, enzymatic degradation, minimally invasive medical devices
MeSH terms
Biocompatible Materials, Cellulose, Decanoic Acids, Elasticity, Glycerol, Lipase, Polymers, Polyurethanes, Surface Properties, Tensile Strength, Absorbable Implants, Nanoparticles, Nanocomposites, Hydrophobic and Hydrophilic Interactions

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