The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations
Open accessAbstract
Transferrin (Tf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells, was chosen as the ligand to develop Tf-conjugated PEGylated nanoscaled graphene oxide (GO) for loading and glioma targeting delivery of anticancer drug doxorubicin (Dox) (Tf-PEG-GO-Dox). Tf-GO with lateral dimensions of 100-400 nm exhibited a Dox loading ratio up to 115.4%. Compared with Dox-loaded PEGylated GO (PEG-GO-Dox) and free Dox, Tf-PEG-GO-Dox displayed greater intracellular delivery efficiency and stronger cytotoxicity against C6 glioma cells. A competition test showed that Tf was essential to glioma targeting in vitro. The HPLC assay for Dox concentration in tumor tissue and contrapart tissue of the brain demonstrated that Tf-PEG-GO-Dox could deliver more Dox into tumor in vivo. The life span of tumor bearing rats after the administration of Tf-PEG-GO-Dox was extended significantly compared to the rats treated with saline, Dox, and PEG-GO-Dox. In conclusion, we developed Tf-PEG-GO-Dox which exhibited significantly improved therapeutic efficacy for glioma both in vitro and in vivo.
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Transferrin receptor on endothelium of brain capillaries
Jefferies, W. A., Brandon, M. R., Hunt, S. V., Williams, A. F., Gatter, K. C., & Mason, D. Y. (1984) · Nature · doi:10.1038/312162a0 · Cited by 1,061
Long-circulating pegylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery.
Calvo, P., Gouritin, B., Chacun, H., Desmaële, D., D'Angelo, J., Noel, J.-P., Georgin, D., Fattal, E., Andreux, J. P., & Couvreur, P. (2001) · Pharmaceutical Research · doi:10.1023/a:1010931127745 · Cited by 443
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Luo, Y., Shen, H., Fang, Y., Cao, Y., Huang, J., Zhang, M., Dai, J., Shi, X., & Zhang, Z. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b00862 · Cited by 323
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Zhao, B., Dong, K., Lin, M., Dong, G., Shan, S., Lawson, T., Yan, L., Zhang, W., Shi, B., Chou, S., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800377 · Cited by 18
Metadata
- Authors
- Liu, G., Shen, H., Mao, J., Zhang, L., Jiang, Z., Sun, T., Lan, Q., & Zhang, Z.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-07-24
- Volume
- 5
- Issue
- 15
- Pages
- 6909-6914
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2079140662
- Cited by
- 184
- References
- 2
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- green
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