Assessing the in Vivo Efficacy of Doxorubicin Loaded Hyaluronan Nanoparticles
Open accessAbstract
Magnetic nanoparticles are attractive platforms for biomedical applications including diagnosis and treatment of diseases. We have shown previously that hyaluronan-coated superparamagnetic iron oxide nanoparticles (HA-SPIONs) enhanced the efficacy of the conjugated anticancer drug doxorubicin (DOX) in vitro against drug-sensitive and drug-resistant human ovarian cancer cells. In this manuscript, we report our findings on the efficacy of DOX loaded HA-SPIONs in vivo using subcutaneous and intraperitoneal SKOV-3 ovarian tumor models in nude mice. The accumulation of the nanoparticles in subcutaneous tumors following an intravenous nanoparticle administration was confirmed by magnetic resonance imaging, and its distribution in the tumors was evaluated by confocal microscopy and Prussian blue staining. DOX delivered by nanoparticles accumulated at much higher levels and distributed wider in the tumor tissue than intravenously injected free DOX, leading to significant reduction of tumor growth. The IVIS Spectrum for in vivo bioluminescence imaging was used to aid in therapy assessment of the DOX-loaded nanoparticles on intraperitoneal ovarian tumors formed by firefly luciferase expressing human ovarian SKOV-3 cells. DOX-loaded HA-SPIONs significantly reduced tumor growth, delayed tumor development, and extended the survival of mice. Thus, utilizing HA-SPIONs as drug delivery vehicles constitutes a promising approach to tackle CD44 expressing ovarian cancer.
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SPION have been loaded with many therapeutics, especially anticancer agents ranging from doxorubicin to siRNA.
“SPION have been loaded with many different therapeutics drugs. Especially anticancer agents have been employed, ranging from standard low molecular weight chemotherapeutics, such as doxorubicin, to more advanced therapeutic compounds, such as siRNA [237, 238].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [237]
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Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works
Drug penetration in solid tumours
Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805 · see citing works
Ozols, R. F., Bundy, B. N., Greer, B. E., Fowler, J. M., Clarke‐Pearson, D. L., Burger, R. A., Mannel, R. S., DeGeest, K., Hartenbach, E. M., & Baergen, R. N. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.153 · Cited by 2,034 · see citing works
Inorganic Nanoparticles for MRI Contrast Agents
Na, H. B., Song, I. C., & Hyeon, T. (2009) · Advanced Materials · doi:10.1002/adma.200802366 · Cited by 1,776 · see citing works
The biology of ovarian cancer: new opportunities for translation
Bast, R. C., Hennessy, B. T., & Mills, G. B. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2644 · Cited by 1,362 · see citing works
Ovarian cancer: strategies for overcoming resistance to chemotherapy
Agarwal, R., & Kaye, S. B. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1123 · Cited by 1,155 · see citing works
Lee, N., & Hyeon, T. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15248c · Cited by 995 · see citing works
Lee, C., Gillies, E. R., Fox, M. E., Guillaudeu, S. J., Fréchet, J. M. J., Dy, E. E., & Szoka, F. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607705103 · Cited by 648 · see citing works
Goff, B. A., Mandel, L. S., Muntz, H. G., & Melancon, C. H. (2000) · Cancer · doi:10.1002/1097-0142(20001115)89:10 · Cited by 505 · see citing works
The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors
Primeau, A. J., Rendon, A., Hedley, D., Lilge, L., & Tannock, I. F. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1664 · Cited by 499 · see citing works
Beyond chemotherapy: targeted therapies in ovarian cancer
Yap, T. A., Carden, C. P., & Kaye, S. B. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2583 · Cited by 495 · see citing works
Zhao, Z., Zhou, Z., Bao, J., Wang, Z., Hu, J., Chi, X., Ni, K., Wang, R., Chen, X. S., Chen, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3266 · Cited by 481 · see citing works
El‐Boubbou, K., Gruden, C. L., & Huang, X. (2007) · Journal of the American Chemical Society · doi:10.1021/ja076086e · Cited by 421 · see citing works
Gore, M. E., Fryatt, I., Wiltshaw, E., & Dawson, T. (1990) · Gynecologic Oncology · doi:10.1016/0090-8258(90)90174-j · Cited by 380 · see citing works
El‐Boubbou, K., Zhu, D. C., Vasileiou, C., Borhan, B., Prosperi, D., Li, W., & Huang, X. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100455c · Cited by 249 · see citing works
Biomedical nanomaterials for imaging-guided cancer therapy
Huang, Y., He, S., Cao, W., Cai, K., & Liang, X. (2012) · Nanoscale · doi:10.1039/c2nr31715j · Cited by 234 · see citing works
Lammers, T., Rizzo, L. Y., Storm, G., & Kiessling, F. M. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1414 · Cited by 195 · see citing works
Intraperitoneal therapy for peritoneal tumors: biophysics and clinical evidence
Ceelen, W. P., & Flessner, M. F. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.217 · Cited by 191 · see citing works
Magnetic Nanoparticles for Cancer Diagnosis and Therapy
Yigit, M. V., Moore, A. V., & Medarova, Z. O. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0679-7 · Cited by 190 · see citing works
Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting and Imaging of Macrophages
Kamat, M. N., El‐Boubbou, K., Zhu, D. C., Lansdell, T. A., Lu, X., Li, W., & Huang, X. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100354m · Cited by 169 · see citing works
Poveda, A. M., Vergote, I. B., Tjulandin, S., Kong, B., Roy, M., Chan, S. Y. T., Filipczyk−Cisarż, E., Hagberg, H., Kaye, S. B., Colombo, N., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq352 · Cited by 162 · see citing works
Placido, S. D., Scambia, G., Vagno, G. D., Naglieri, E., Lombardi, A. V., Biamonte, R., Marinaccio, M., Cartenì, G., Manzione, L., Febbraro, A., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.088 · Cited by 161 · see citing works
Anthracycline nano-delivery systems to overcome multiple drug resistance: A comprehensive review
Ma, P., & Mumper, R. J. (2013) · Nano Today · doi:10.1016/j.nantod.2013.04.006 · Cited by 138 · see citing works
Kanwar, J. R., Sun, X., Punj, V., Sriramoju, B., Mohan, R. R., Zhou, S., Chauhan, A., & Kanwar, R. K. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.08.006 · Cited by 135 · see citing works
Nanotechnology imaging probes: smaller and more stable
Baker, M. (2010) · Nature Methods · doi:10.1038/nmeth1210-957 · Cited by 128 · see citing works
El‐Dakdouki, M. H., Zhu, D. C., El‐Boubbou, K., Kamat, M. N., Chen, J., Li, W., & Huang, X. (2012) · Biomacromolecules · doi:10.1021/bm300046h · Cited by 123 · see citing works
The pharmacokinetics of polymer-bound adriamycin
Seymour, L. W., Ulbrich, K., Strohalm, J., Kopec̆ek, J., & Duncan, R. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90293-t · Cited by 122 · see citing works
WAGNER, U., duBois, A., Pfisterer, J., Huober, J., Loibl, S., Lück, H., Sehouli, J., Gropp, M., Stähle, A., & Schmalfeldt, B. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2006.10.053 · Cited by 89 · see citing works
Intraperitoneal Chemotherapy in Ovarian Cancer Remains Experimental
Gore, M. E., du Bois, A., & Vergote, I. B. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.0376 · Cited by 82 · see citing works
New therapies for ovarian cancer: Cytotoxics and molecularly targeted agents
Dinh, P., Harnett, P. R., Piccart, M. J., & Awada, A. H. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2008.01.012 · Cited by 78 · see citing works
Sorafenib in Combination With Gemcitabine in Recurrent Epithelial Ovarian Cancer
Welch, S. A., Hirte, H. W., Elit, L. M., Schilder, R. J., Wang, L. E., MacAlpine, K., Wright, J. J., & Oza, A. M. (2010) · International Journal of Gynecological Cancer · doi:10.1111/igc.0b013e3181e273a8 · Cited by 61 · see citing works
Kouyoumdjian, H., Zhu, D. C., El-Dakdouki, M. H., Lorenz, K., Chen, J.-J., Li, W., & Huang, X. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn3002015 · Cited by 59 · see citing works
Li, H., El‐Dakdouki, M. H., Zhu, D. C., Abela, G. S., & Huang, X. (2012) · Chemical Communications · doi:10.1039/c2cc17852d · Cited by 59 · see citing works
Sun (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s2714 · Cited by 56 · see citing works
El‐Dakdouki, M. H., Puré, E., & Huang, X. (2013) · Nanoscale · doi:10.1039/c3nr90022c · Cited by 55 · see citing works
CD44 Targeting Magnetic Glyconanoparticles for Atherosclerotic Plaque Imaging
El‐Dakdouki, M. H., El‐Boubbou, K., Kamat, M. N., Huang, R., Abela, G. S., Kiupel, M., Zhu, D. C., & Huang, X. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1021-8 · Cited by 53 · see citing works
The Future of Targeted Therapies in Ovarian Cancer
Banerjee, S. N., & Gore, M. E. (2009) · The Oncologist · doi:10.1634/theoncologist.2009-0013 · Cited by 50 · see citing works
Chen, B., Li, K., Guohua, X., Cheng, J., Wang, J., FenGao, Xu, L., Feng, J., & Wang, X. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s43752 · Cited by 43 · see citing works
El‐Dakdouki, M. H., El‐Boubbou, K., Zhu, D. C., & Huang, X. (2011) · RSC Advances · doi:10.1039/c1ra00737h · Cited by 42 · see citing works
El‐Dakdouki, M. H., Puré, E., & Huang, X. (2013) · Nanoscale · doi:10.1039/c3nr33777d · Cited by 35 · see citing works
Chen, B. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s5093 · Cited by 33 · see citing works
Chen, B. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s5393 · Cited by 30 · see citing works
Overcoming multidrug resistance (MDR) in cancer by nanotechnology
Bu, H., Gao, Y., & Li, Y. (2010) · Science China Chemistry · doi:10.1007/s11426-010-4142-5 · Cited by 29 · see citing works
Intraperitoneal Chemotherapy in Patients with Advanced Ovarian Cancer: The Con View
Vergote, I. B., Amant, F. C., Leunen, K., Cadron, I., Gorp, T. V., Neven, P., & Berteloot, P. (2008) · The Oncologist · doi:10.1634/theoncologist.2007-0224 · Cited by 25 · see citing works
Doxorubicin compared with related compounds in a nude mouse model for human ovarian cancer
Boven, E., Schlüper, H. M. M., Erkelens, C. A. M., & Pinedo, H. M. (1990) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(90)90626-5 · Cited by 19 · see citing works
Molecular Targeted Therapy in Ovarian Cancer
Kalachand, R. D., Hennessy, B. T., & Markman, M. M. (2011) · Drugs · doi:10.2165/11591740-000000000-00000 · Cited by 19 · see citing works
Bionanotechnologies for treatment and diagnosis of Alzheimer's disease
Moghimi, S. M. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.05.001 · Cited by 18 · see citing works
Strategies to examine new compounds for intraperitoneal use in ovarian cancer
Markman, M. (2008) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.01102.x · Cited by 11 · see citing works
Turning promise into progress for antiangiogenic agents in epithelial ovarian cancer
van der Bilt, A. R. M., de Vries, E. G. E., de Jong, S., Timmer‐Bosscha, H., van der Zee, A. G. J., & Reyners, A. K. L. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.03.006 · Cited by 8 · see citing works
Prayer, L., Stiglbauer, R., Kramer, J., Wimberger, D., Poelzleitner, D., Schima, W., Kainz, C., Koelbl, H., Haugen, I. K., & Imhof, H. (1993) · British Journal of Radiology · doi:10.1259/0007-1285-66-785-415 · Cited by 7 · see citing works
Faster, sharper electron microscopy
Baker, M. (2010) · Nature Methods · doi:10.1038/nmeth0710-494 · Cited by 7 · see citing works
Epithelial Ovarian Cancer: Focus on Targeted Therapy
Markman, M. M., Sehouli, J., Levenback, C. F., & Dennis, S. (2010) · Journal of Oncology · doi:10.1155/2010/171425 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [37]Chen B Sun Q Wang X Gao F Dai Y Yin Y Ding J Gao C Cheng J Li J Sun X Chen N Xu W Shen H Liu D Int J Nanomed 2008 3 277 286 PMC2527663 18686787
- [38]Li K Chen B Xu L Feng J Xia G Cheng J Wang J Gao F Wang X Int J Nanomed 2013 8 1867 1877 PMC3656817 23690684
- [40]Jiang Z Chen BA Xia GH Wu Q Zhang Y Hong TY Zhang W Cheng J Gao F Liu LJ Li XM Wang XM Int J Nanomed 2009 4 107 114 PMC2720746 19516889
Cited by
Sorted by citations
The biology and role of CD44 in cancer progression: therapeutic implications
Chen, C., Zhao, S., Karnad, A. B., & Freeman, J. W. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0605-5 · Cited by 1,404 · see citing works
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges
Tripodo, G., Trapani, A., Torre, M. L., Giammona, G., Trapani, G., & Mandracchia, D. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.032 · Cited by 286 · see citing works
Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy
Zhi, D., Yang, T., Yang, J. Y., Fu, S., & Zhang, S. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.11.027 · Cited by 287 · see citing works
The Role of CD44 in Disease Pathophysiology and Targeted Treatment
Jordan, A. R., Racine, R. R., Hennig, M. J. P., & Lokeshwar, V. B. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00182 · Cited by 272 · see citing works
Hyaluronan as a therapeutic target in human diseases
Liang, J., Jiang, D., & Noble, P. W. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.017 · Cited by 239 · see citing works
Wang, H., Agarwal, P., Zhao, S., Xu, R. X., Yu, J., Lu, X., & He, X. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.048 · Cited by 217 · see citing works
Arabi, L., Badiee, A., Mosaffa, F., & Jaafari, M. R. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.044 · Cited by 183 · see citing works
Shen, S., Wu, L. H., Liu, J., Xie, M., Shen, H., Qi, X., Yan, Y., Ge, Y., & Jin, Y. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.03.070 · Cited by 165 · see citing works
Targeting Hyaluronic Acid Family for Cancer Chemoprevention and Therapy
Lokeshwar, V. B., Mirza, S., & Jordan, A. R. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800092-2.00002-2 · Cited by 159 · see citing works
Polysaccharides based nanomaterials for targeted anti-cancer drug delivery
Dheer, D., Arora, D., Jaglan, S., Rawal, R. K., & Shankar, R. (2016) · Journal of drug targeting · doi:10.3109/1061186x.2016.1172589 · Cited by 132 · see citing works
Wang, H., Agarwal, P., Zhao, S., Yu, J., Lu, X., & He, X. (2015) · Nature Communications · doi:10.1038/ncomms10081 · Cited by 112 · see citing works
RetractedNasr, S. H., Rashidijahanabad, Z., Ramadan, S., Kauffman, N., Parameswaran, N., Zinn, K. R., Qian, C., Arora, R., Agnew, D., & Huang, X. (2020) · Nanoscale · doi:10.1039/d0nr00308e · Cited by 90 · see citing works
Hyaluronan-Coated Extracellular Vesicles—A Novel Link Between Hyaluronan and Cancer
Rilla, K. J., Siiskonen, H., Tammi, M., & Tammi, R. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800092-2.00005-8 · Cited by 90 · see citing works
Hyaluronan-Inorganic Nanohybrid Materials for Biomedical Applications
Cai, Z., Zhang, H., Wei, Y. Z., & Cong, F. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00424 · Cited by 87 · see citing works
Agrawal, S., Dwivedi, M., Ahmad, H., Chadchan, S. B., Arya, A. K., Sikandar, R., Kaushik, S., Mitra, K., Jha, R. K., & Dwivedi, A. K. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.10.010 · Cited by 83 · see citing works
Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy
Muntimadugu, E., Kommineni, N., & Khan, W. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.010 · Cited by 82 · see citing works
Bano, S., Dey, T., Sharma, S., & Kundu, S. C. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/am506094c · Cited by 81 · see citing works
Li, X., Wang, X., Sha, L., Wang, D., Shi, W., Zhao, Q., & Wang, S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b03008 · Cited by 78 · see citing works
Yang, Y., Hou, W., Liu, S., Sun, K., Li, M., & Wu, C. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01469 · Cited by 69 · see citing works
Zhao, Q., Yang, Y., Wang, H., Lei, W., Liu, Y., & Wang, S. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.07.005 · Cited by 66 · see citing works
Multifunctional theranostic nanoparticles for biomedical cancer treatments - A comprehensive review
Kandasamy, G., & Maity, D. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112199 · Cited by 65 · see citing works
Selective Photothermal Tumor Therapy Using Nanodiamond‐Based Nanoclusters with Folic Acid
Ryu, T., Baek, S. W., Kang, R. H., & Choi, S. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601207 · Cited by 65 · see citing works
Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade
Sohail, M., Guo, W., Li, Z., Xu, H. Z., Zhao, F., Chen, D., & Fu, F. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666201005111722 · Cited by 63 · see citing works
Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development
Roedig, H., Damiescu, R., Zeng-Brouwers, J., Kutija, I., Trebicka, J., Wygrecka, M., & Schaefer, L. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.026 · Cited by 58 · see citing works
Ryu, T., Baek, S., Kang, R. H., Jeong, K., Jun, D.-R., & Choi, S. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.008 · Cited by 57 · see citing works
Jian, Y.-S., Chen, C., Lin, C.-A., Yu, H., Lin, H.-Y., Liao, M., Wu, S., Lin, Y.-F., & Lai, P. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s120847 · Cited by 54 · see citing works
Šmejkalová, D., Nešporová, K., Huerta‐Ángeles, G., Syrovátka, J., Jirák, D., Gálisová, A., & Velebný, V. (2014) · Biomacromolecules · doi:10.1021/bm501065q · Cited by 54 · see citing works
Ibarra, L. E., Tarres, L., Abel, S. B., Barbero, C. A., Kogan, M. J., Rivarola, V. A., Bertuzzi, M. L., & Yslas, E. I. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.01.013 · Cited by 52 · see citing works
Ultra-small Fe3O4 nanoparticles for nuclei targeting drug delivery and photothermal therapy
Wen, W., Wu, L. H., Chen, Y., Qi, X., Cao, J., Zhang, X., Ma, W., Ge, Y., & Shen, S. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101782 · Cited by 52 · see citing works
Sharma, S., Singh, J., Verma, A., Teja, B. V., Shukla, R. P., Singh, S. K., Sharma, V., Konwar, R., & Mishra, P. R. (2016) · RSC Advances · doi:10.1039/c6ra11260a · Cited by 49 · see citing works
Wan, X., Song, Y., Song, N., Li, J., Yang, L., Li, Y., & Tan, H. Q. (2015) · Carbohydrate Research · doi:10.1016/j.carres.2015.11.003 · Cited by 48 · see citing works
Espinosa‐Cano, E., Huerta-Madroñal, M., Cámara‐Sánchez, P., Seras‐Franzoso, J., Schwartz, S., Abasolo, I., Román, J. S., & Aguilar, M. R. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112024 · Cited by 45 · see citing works
Vyas, D., Lopez‐Hisijos, N., Gandhi, S., El‐Dakdouki, M. H., Basson, M. D., Walsh, M. F., Huang, X., Vyas, A. K., & Chaturvedi, L. S. (2015) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2015.10834 · Cited by 44 · see citing works
Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer
Nikitovic, D., Kouvidi, K., Kavasi, R., Berdiaki, A., & Tzanakakis, G. N. (2015) · Current Drug Delivery · doi:10.2174/1567201813666151109103013 · Cited by 36 · see citing works
Lu, K.-Y., Lin, C., Hsu, C., Ho, Y., Chuang, E., Sung, H., & Mi, F. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am505441p · Cited by 35 · see citing works
Zhao, Q., Wang, X., Yang, M., Li, X., Mao, Y., Guan, X., Di, D., & Wang, S. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110532 · Cited by 33 · see citing works
Engineering Biomaterial-Drug Conjugates for Local and Sustained Chemotherapeutic Delivery
Coburn, J., & Kaplan, D. (2015) · Bioconjugate chemistry · doi:10.1021/acs.bioconjchem.5b00046 · Cited by 32 · see citing works
Szafraniec-Szczęsny, J., Błażejczyk, A., Kuś, E., Janik-Hazuka, M., Zając, G., Wietrzyk, J., Chłopicki, S., & Zapotoczny, S. (2017) · Nanoscale · doi:10.1039/c7nr05851a · Cited by 30 · see citing works
Anticancer Effects of Sinulariolide-Conjugated Hyaluronan Nanoparticles on Lung Adenocarcinoma Cells
Hsiao, K. Y., Wu, Y., Liu, Z., Chuang, C., Huang, H. H., & Kuo, S. M. (2016) · Molecules · doi:10.3390/molecules21030297 · Cited by 29 · see citing works
Xifré‐Pérez, E., Guaita‐Esteruelas, S., Baranowska, M., Pallarès, J., Masana, L., & Marsal, L. F. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b05016 · Cited by 27 · see citing works
Targeted Tumor Therapy Based on Nanodiamonds Decorated with Doxorubicin and Folic Acid
Ryu, T., Baek, S. W., Lee, G.-J., Rhee, C., & Choi, S. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600180 · Cited by 26 · see citing works
Opportunities for glyconanomaterials in personalized medicine
Reichardt, N., Martín‐Lomas, M., & Penadés, S. (2016) · Chemical Communications · doi:10.1039/c6cc04445j · Cited by 25 · see citing works
Modifying superparamagnetic iron oxides nanoparticles for doxorubicin delivery carriers: a review
Doan, L., Nguyen, L. T., & Nguyen, N. T. (2023) · Journal of Nanoparticle Research · doi:10.1007/s11051-023-05716-3 · Cited by 24 · see citing works
Mérian, J., Souza, R. D., Dou, Y. N., Ekdawi, S. N., Ravenelle, F., & Allen, C. J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.04.060 · Cited by 22 · see citing works
Combinatorial synthesis of a hyaluronan based polysaccharide library for enhanced CD44 binding
Liu, K., McCue, W. M., Yang, C.-W., Finzel, B. C., & Huang, X. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.120255 · Cited by 21 · see citing works
Bahjat, H. H., Ismail, R. A., Sulaiman, G. M., Mohammed, H. A., Al-Omar, M. S., Mohammed, S. A. A., & Khan, R. A. (2022) · Bioinorganic Chemistry and Applications · doi:10.1155/2022/1854473 · Cited by 21 · see citing works
RetractedLü, N., Wen, Y., Liu, G., Ding, L., Zeng, C., Aldalbahi, A. K., Khan, M. N., Periyasami, G., Rahaman, M., Alrohaili, A., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b08732 · Cited by 18 · see citing works
Hyaluronic acid-conjugated lipid nanocarriers in advancing cancer therapy: A review
Zhang, G., Jiang, X. Y., Xia, Y., Qi, P., Li, J., Wang, L., Wang, Z., & Tian, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140146 · Cited by 17 · see citing works
Alavi, S., Haeri, A., Mahlooji, I., & Dadashzadeh, S. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02818-8 · Cited by 18 · see citing works
Lim, C., Shin, Y., Lee, S., Lee, S., Lee, M., Shin, B. S., & Oh, K. T. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103825 · Cited by 15 · see citing works
Polysaccharide nanoparticles for cancer drug targeting
Zhu, Y., Liu, Y., Jin, K., & Pang, Z. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102553-6.00013-1 · Cited by 14 · see citing works
Nguyen, H.-V. T., Mai, N. X. D., Lai, H. T., Nguyễn, L. H. T., Pham, Q. T., Nguyen, H. V., Le, M.-T., Nguyen, H. T., Vong, L. B., & Đoàn, T. L. H. (2024) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2024.135914 · Cited by 10 · see citing works
Advances in nanobubbles for cancer theranostics: Delivery, imaging and therapy
Na, L., & Fan, F. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116341 · Cited by 8 · see citing works
Liu, T., Huang, X., Zhao, L., Xiao, Z., Li, Z., Xin, Y., Yang, S., Guo, D., Zhao, W., Mi, Y., et al. (2021) · ChemistryOpen · doi:10.1002/open.202100070 · Cited by 8 · see citing works
Hyaluronic acid-based drug delivery systems for targeted cancer therapy
Devan, A. R., Sah, S. K., Nair, B., Sudheesh, M. S., & Nath, L. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98827-8.00017-5 · Cited by 4 · see citing works
Polymeric Nanoencapsulation of Indocyanine green for Photodynamic Therapy Technique
Saboktakin, M. R. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.03.000630 · Cited by 4 · see citing works
Recent advances in molecular diagnostics and therapeutic targets for pancreatic cancer
Clay, R., & Siddiqi, S. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-819457-7.00016-5 · Cited by 3 · see citing works
Role of Polysaccharides Mimetic Components in Targeted Cancer Treatment
Gupta, N., & Malviya, R. (2022) · Current Drug Targets · doi:10.2174/1389450123666220214121505 · Cited by 3 · see citing works
El‐Dakdouki, M. H., Hussein, A., Abdallah, H. S., Shatila, R., & Mouneimne, Y. (2017) · Tetrahedron · doi:10.1016/j.tet.2017.08.027 · Cited by 3 · see citing works
Innovative therapy of ovarian cancer based on overexpression of CD44 receptor
Bukowska, B., & Marczak, A. (2015) · Ginekologia Polska · doi:10.17772/gp/2428 · Cited by 3 · see citing works
Carbohydrate Nanotechnology and its Applications for the Treatment of Cancer
Ambre, S. G., & Barchi, J. J. (2015) · doi:10.1002/9781118860212.ch13 · Cited by 3 · see citing works
Recent advances in glyco-nanoparticles for probing the glyco-codes of cancer
Ullah, A. K. M. A., & Huang, X. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109757 · Cited by 2 · see citing works
Design of Iron Oxide Nanoparticles as Theranostic Nanoplatforms for Cancer Treatment
Gevart, T., Freis, B., Vangijzegem, T., Ramírez, M. D. L. Á., Stanicki, D., Bégin‐Colin, S., & Laurent, S. (2024) · Topics in applied physics · doi:10.1007/978-3-031-58376-6_13 · Cited by 2 · see citing works
Profiling Carbohydrate-Protein Interaction Using Nanotechnology
Cooper, O., & Tiralongo, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819475-1.00012-2 · Cited by 2 · see citing works
Lim, C., Shin, Y., Lee, S., Lee, M., Shin, B. S., & Oh, K. T. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4157167
Accounts on the Nano-carrier System for Diagnosis Purposes
Pandey, S. P., Jangied, P., Shukla, T., Tripathi, A., & Upmanyu, N. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815080506123010013
Park, J. H., & Park, I. Y. (2023) · Journal of Surgical Ultrasound · doi:10.46268/jsu.2023.10.2.32
- Authors
- El-Dakdouki, M. H., Xia, J., Zhu, D. C., Kavunja, H., Grieshaber, J., O’Reilly, S., McCormick, J. J., & Huang, X.
- Affiliations
- Department of Chemistry, Beirut Arab University, P.O. Box 11-5020 Riad El Solh 11072809, Beirut, Lebanon
- Michigan State University (US)
- Corresponding author
- Huang, Xuefei
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-12-12
- Volume
- 6
- Issue
- 1
- Pages
- 697-705
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- PMC
- PMC3912576
- OpenAlex
- W2037774202
- Cited by
- 69
- References
- 53
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 2 · 2017: 9 · 2016: 6 · 2015: 17 · 2014: 4
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA149451)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- doxorubicin, hyaluronic acid, superparamagnetic iron oxide nanoparticles, drug delivery, ovarian cancer, SKOV3 cells, CD44, magnetic resonance imaging, bioluminescence imaging, intraperitoneal tumor, nanoparticle toxicity
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Doxorubicin, Female, Humans, Hyaluronic Acid, Magnetic Resonance Imaging, Mice, Nude, Ovarian Neoplasms, Xenograft Model Antitumor Assays, Mice, Nanoparticles
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